PMID- 37395706
OWN - NLM
STAT- MEDLINE
DCOM- 20230705
LR  - 20230708
IS  - 2164-2591 (Electronic)
IS  - 2164-2591 (Linking)
VI  - 12
IP  - 7
DP  - 2023 Jul 3
TI  - Factors Associated With Visual Acuity Decline in Glaucoma Patients With Loss of 
      Ganglion Cell Complex Thickness.
PG  - 2
LID - 10.1167/tvst.12.7.2 [doi]
LID - 2
AB  - PURPOSE: To investigate the association between ocular/systemic factors and 
      visual acuity decline in glaucoma patients with loss of ganglion cell complex 
      thickness (GCCT). METHODS: In 515 eyes of 515 patients with open-angle glaucoma 
      (mean age, 62.6 +/- 12.8 years; mean deviation, -10.95 +/- 9.07 dB), we used 
      swept-source optical coherence tomography to measure macular GCCT in sectors 
      classified as corresponding to circumpapillary retinal nerve fiber layer 
      clock-hour sectors from 7 o'clock (inferotemporal) to 11 o'clock 
      (superotemporal). We calculated Spearman's rank correlation coefficient between 
      each sector and best-corrected visual acuity (BCVA), determined cutoff values for 
      BCVA decline (<20/25), and used multivariable linear regression models to 
      determine the correlation between BCVA and biological antioxidant potential 
      (BAP), corneal hysteresis (CH), and temporal-tissue optic nerve head blood flow 
      (represented by temporal mean blur rate, or MBR-T). RESULTS: Macular GCCT 
      corresponding to the 9 o'clock sector had the highest correlation with BCVA (Rs = 
      -0.454; P < 0.001) and a cutoff of 76.17 microm (area under the receiver operating 
      characteristic curve = 0.891; P < 0.001). Subjects below this cutoff (N = 173) 
      showed significant correlations between BCVA and age, BAP, CH, and MBR-T (beta = 
      0.192, P = 0.033; beta = -0.186, P = 0.028; beta = -0.217, P = 0.011; and beta = -0.222, P 
      = 0.010, respectively). CONCLUSIONS: Multiple factors are involved in BCVA 
      decline in patients with glaucoma with decreased macular GCCT. This suggests that 
      evaluating BCVA may require assessing multiple factors. TRANSLATIONAL RELEVANCE: 
      Multiple factors contribute to BCVA decline.
FAU - Takahashi, Naoki
AU  - Takahashi N
AD  - Department of Ophthalmology, Tohoku University Graduate School of Medicine, 
      Sendai, Japan.
FAU - Omodaka, Kazuko
AU  - Omodaka K
AD  - Department of Ophthalmology, Tohoku University Graduate School of Medicine, 
      Sendai, Japan.
FAU - Kikawa, Tsutomu
AU  - Kikawa T
AD  - Research & Development Division, Topcon Corporation, Tokyo, Japan.
FAU - Ninomiya, Takahiro
AU  - Ninomiya T
AD  - Department of Ophthalmology, Tohoku University Graduate School of Medicine, 
      Sendai, Japan.
FAU - Kiyota, Naoki
AU  - Kiyota N
AD  - Department of Ophthalmology, Tohoku University Graduate School of Medicine, 
      Sendai, Japan.
FAU - Tsuda, Satoru
AU  - Tsuda S
AD  - Department of Ophthalmology, Tohoku University Graduate School of Medicine, 
      Sendai, Japan.
FAU - Himori, Noriko
AU  - Himori N
AD  - Department of Ophthalmology, Tohoku University Graduate School of Medicine, 
      Sendai, Japan.
AD  - Department of Aging Vision Healthcare, Tohoku University Graduate School of 
      Biomedical Engineering, Sendai, Japan.
FAU - Nakazawa, Toru
AU  - Nakazawa T
AD  - Department of Ophthalmology, Tohoku University Graduate School of Medicine, 
      Sendai, Japan.
AD  - Department of Retinal Disease Control, Ophthalmology, Tohoku University Graduate 
      School of Medicine, Sendai, Japan.
AD  - Department of Advanced Ophthalmic Medicine, Tohoku University Graduate School of 
      Medicine, Sendai, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transl Vis Sci Technol
JT  - Translational vision science & technology
JID - 101595919
SB  - IM
MH  - Humans
MH  - Middle Aged
MH  - Aged
MH  - *Glaucoma, Open-Angle/complications
MH  - Retinal Ganglion Cells
MH  - Nerve Fibers
MH  - *Glaucoma/diagnosis
MH  - Visual Acuity
PMC - PMC10324415
COIS- Disclosure: N. Takahashi, None; K. Omodaka, None; T. Kikawa, Topcon (E); T. 
      Ninomiya, None; N. Kiyota, None; S. Tsuda, None; N. Himori, None; T. Nakazawa, 
      None
EDAT- 2023/07/03 13:05
MHDA- 2023/07/05 06:42
PMCR- 2023/07/03
CRDT- 2023/07/03 10:33
PHST- 2023/07/05 06:42 [medline]
PHST- 2023/07/03 13:05 [pubmed]
PHST- 2023/07/03 10:33 [entrez]
PHST- 2023/07/03 00:00 [pmc-release]
AID - 2791264 [pii]
AID - TVST-22-5335 [pii]
AID - 10.1167/tvst.12.7.2 [doi]
PST - ppublish
SO  - Transl Vis Sci Technol. 2023 Jul 3;12(7):2. doi: 10.1167/tvst.12.7.2.