PMID- 37395760
OWN - NLM
STAT- MEDLINE
DCOM- 20230731
LR  - 20230916
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Linking)
VI  - 280
IP  - 9
DP  - 2023 Sep
TI  - Preoperative embolization is necessary for large-volume carotid body tumor 
      (>/= 6670 mm(3)) resection.
PG  - 4177-4183
LID - 10.1007/s00405-023-07990-2 [doi]
AB  - BACKGROUND: To investigate the impact of preoperative embolization (p-TAE) on CBT 
      surgical resection and explore the optimal tumor volume for p-TAE of CBT 
      resection. METHODS: This retrospective study reviewed 139 surgically excised 
      CBTs. According to Shamblin classification, tumor volumes, and whether to carry 
      out the p-TAE, the patients were classified into different groups. The 
      demographic, clinical features, and the intraoperative and post-operative 
      information about the patients were retrieved and analyzed from the patient 
      records. RESULTS: A total of 139 CBTs was excised in 130 patients. According to 
      the results of subgroup analysis, there were no significant differences in 
      surgical time, blood loss, adverse events (AEs), and the revascularization when 
      compared with non-embolization group (NEG) for type I, II, III, respectively (all 
      p > 0.05) except for the surgical time in type I (p < 0.05). Then the X-tile 
      program was employed and determine the cutoff point (tumor volume = 6670 mm(3)) 
      for tumor volumes and blood loss. The average tumor volume was (29,782.37 vs. 
      31,345.10 mm(3), p = 0.65) for embolization group (EG) and NEG. The mean surgical 
      time (208.86 vs. 264.67 min, p > 0.05) and intraoperative blood loss (252.78 vs. 
      430.00 mL, p < 0.05) were less, and the incidence of revascularization required 
      (35.56 vs. 52.38%, p > 0.05) and total complications (27.78 vs. 57.14%, p < 0.05) 
      were lower in EG when compared with NEG (tumor volume >/= 6670 mm(3)). However, the 
      results were not statistically significant when the tumor size was less than 
      6670 mm(3). No surgery-related mortality was observed during the follow-up. 
      CONCLUSIONS: Preoperative selective embolization of CBT is an effective and safe 
      adjunct for surgical resection, especially for Shamblin class II and III tumors 
      (>/= 6670 mm(3)).
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Nan, Li
AU  - Nan L
AD  - The First Affiliated Hospital of Jinan University, Guangzhou, 510630, Guangdong, 
      China.
AD  - Department of Interventional Radiology, Guangzhou First People's Hospital, 
      Guangzhou, 510180, China.
AD  - Department of Interventional Radiology, The First Affiliated Hospital, Sun 
      Yat-Sen University, Guangzhou, 510080, Guangdong, China.
FAU - Ruimeng, Yang
AU  - Ruimeng Y
AD  - Department of Interventional Radiology, Guangzhou First People's Hospital, 
      Guangzhou, 510180, China.
FAU - Guangqi, Chang
AU  - Guangqi C
AD  - Department of Vascular Surgery, the First Affiliated Hospital, Sun Yat-Sen 
      University, Guangzhou, 510080, Guangdong, China. changgq@mail.sysu.edu.cn.
FAU - Yonghui, Huang
AU  - Yonghui H
AUID- ORCID: 0000-0002-6100-0093
AD  - Department of Interventional Radiology, The First Affiliated Hospital, Sun 
      Yat-Sen University, Guangzhou, 510080, Guangdong, China. hyongh@mail.sysu.edu.cn.
LA  - eng
GR  - 20231A011006/Project of Guangzhou Municipal Health Bureau, China/
PT  - Journal Article
DEP - 20230703
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European 
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the 
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
SB  - IM
MH  - Humans
MH  - *Carotid Body Tumor/diagnostic imaging/surgery
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - *Embolization, Therapeutic/methods
MH  - Vascular Surgical Procedures/adverse effects
OTO - NOTNLM
OT  - Blood loss
OT  - Carotid body tumor
OT  - Preoperative embolization
OT  - Shamblin classification
OT  - Surgical resection
OT  - Tumor volume
EDAT- 2023/07/03 13:05
MHDA- 2023/07/31 06:42
CRDT- 2023/07/03 11:04
PHST- 2023/03/07 00:00 [received]
PHST- 2023/04/18 00:00 [accepted]
PHST- 2023/07/31 06:42 [medline]
PHST- 2023/07/03 13:05 [pubmed]
PHST- 2023/07/03 11:04 [entrez]
AID - 10.1007/s00405-023-07990-2 [pii]
AID - 10.1007/s00405-023-07990-2 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2023 Sep;280(9):4177-4183. doi: 
      10.1007/s00405-023-07990-2. Epub 2023 Jul 3.