PMID- 37396160
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230704
IS  - 2225-4110 (Print)
IS  - 2225-4110 (Electronic)
IS  - 2225-4110 (Linking)
VI  - 13
IP  - 4
DP  - 2023 Jul
TI  - Antihyperglycemic and anti-type 2 diabetic activity of marine hydroquinone 
      isolated from brown algae (Dictyopteris polypodioides).
PG  - 408-416
LID - 10.1016/j.jtcme.2023.03.007 [doi]
AB  - BACKGROUND AND AIMS: Brown algae (Dictyopteris polypodioides) extract (DP) 
      presented high inhibitory potential against alpha-amylase. The present study aims to 
      isolate, purify and evaluate the antihyperglycemic and anti-type 2 diabetic 
      activities of marine hydroquinone from DP. METHODS: Marine hydroquinones were 
      isolated using silica gel, HPLC, and NMR spectroscopy was used to identify 
      compound 1 and compound 2 as zonarol and isozonarol, respectively. The 
      anti-hyperglycemic and anti-type 2 diabetic activities of zonarol were 
      investigated by in vitro assay (alpha-amylase, alpha-glucosidase), Lineweaver-Burk plot 
      and Type 2 diabetes mellitus model (T2DM) mice induced by streptozotocin (STZ). 
      RESULT: Zonarol had the highest content and the strongest inhibitory activity 
      against alpha-glucosidase (IC(50) value of 6.03 mg L(-1)) and alpha-amylase (IC(50) value 
      of 19.29 mg L(-1)) in a competitive inhibition and mix-type manner, respectively. 
      The maltose and starch loading tests revealed that zonarol significantly reduced 
      postprandial glycemia after 30 min loading (9.12 and 8.12 mg/dL, respectively), 
      compared to normal (11.37 and 12.37 mg/dL, respectively). Zonarol exhibited 
      pancreatic islet cell rejuvenation, as evidenced by increased pancreatic islet 
      mass, and hence helps in the restoration of insulin levels and therefore improves 
      the glucose metabolism in STZ-induced diabetic mice. Zonarol treatment in T2DM 
      elevated abundant levels of main SCFAs (propionate, butyrate, and valeric acid), 
      which are closely related to glucose metabolism homeostasis. CONCLUSION: Our 
      finding indicates that zonarol could be used as a food supplement to treat 
      hyperglycemia and diabetes.
CI  - (c) 2023 Center for Food and Biomolecules, National Taiwan University. Production 
      and hosting by Elsevier Taiwan LLC.
FAU - Truong, Thi Phuong Thao
AU  - Truong TPT
AD  - Department of Biology, College of Natural Sciences, Can Tho University, 94000, 
      Viet Nam.
FAU - Tran, Thanh Men
AU  - Tran TM
AD  - Department of Biology, College of Natural Sciences, Can Tho University, 94000, 
      Viet Nam.
FAU - Dai, Thi Xuan Trang
AU  - Dai TXT
AD  - Department of Biology, College of Natural Sciences, Can Tho University, 94000, 
      Viet Nam.
FAU - Tran, Chi Linh
AU  - Tran CL
AD  - Department of Biology, College of Natural Sciences, Can Tho University, 94000, 
      Viet Nam.
LA  - eng
PT  - Journal Article
DEP - 20230320
PL  - Netherlands
TA  - J Tradit Complement Med
JT  - Journal of traditional and complementary medicine
JID - 101605474
PMC - PMC10310914
OTO - NOTNLM
OT  - Anti-hyperglycemia
OT  - Antidiabetic
OT  - Marine hydroquinone
OT  - brown algae
OT  - alpha-amylase
OT  - alpha-glucosidase
COIS- None.
EDAT- 2023/07/03 13:05
MHDA- 2023/07/03 13:06
PMCR- 2023/03/20
CRDT- 2023/07/03 11:16
PHST- 2022/06/23 00:00 [received]
PHST- 2023/02/27 00:00 [revised]
PHST- 2023/03/18 00:00 [accepted]
PHST- 2023/07/03 13:06 [medline]
PHST- 2023/07/03 13:05 [pubmed]
PHST- 2023/07/03 11:16 [entrez]
PHST- 2023/03/20 00:00 [pmc-release]
AID - S2225-4110(23)00042-1 [pii]
AID - 10.1016/j.jtcme.2023.03.007 [doi]
PST - epublish
SO  - J Tradit Complement Med. 2023 Mar 20;13(4):408-416. doi: 
      10.1016/j.jtcme.2023.03.007. eCollection 2023 Jul.