PMID- 37398831
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230704
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 15
IP  - 5
DP  - 2023 May
TI  - Independent Predictors of Mortality in Systemic Sclerosis-Associated Pulmonary 
      Arterial Hypertension: A Systematic Review and Meta-Analysis.
PG  - e39730
LID - 10.7759/cureus.39730 [doi]
LID - e39730
AB  - The aim of this study is to determine the predictors of mortality in patients 
      with systemic sclerosis-induced pulmonary arterial hypertension (SSc-PAH). This 
      systematic review and meta-analysis were carried out according to the Preferred 
      Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) Statement 
      guidelines. We searched the PubMed, EMBASE, and Web of Science databases from 
      January 2010 to April 2023 using the following keywords: "systemic sclerosis," 
      "pulmonary arterial hypertension," "death," and "predictors," along with medical 
      subject headings (MeSH), to identify relevant studies. A total of eight studies 
      with a total of 530 patients were included in the present systematic review and 
      meta-analysis. The pooled one-year, three-year, and five-year survival was 90% 
      (95% CI: 86-93%), 66% (95% CI: 59-72%), and 44% (95% CI: 23-65%), respectively. 
      Factors associated with mortality in SSc-PAH included age (p-value: 0.02), male 
      gender (p-value: 0.008), pericardial effusion (p-value: 0.003), cardiac index 
      (p-value: 0.0001), six-minute walking distance (p-value: 0.04), pulmonary 
      arterial pressure (PAP) (p-value: 0.01), and New York Heart Association (NYHA) 
      classification (p-value: 0.0002). The findings of this study have important 
      clinical implications. Assessing and managing the identified predictors, such as 
      age, gender, pericardial effusion, PAP, cardiac index, and NYHA class, could help 
      identify individuals at higher risk of mortality and guide treatment strategies.
CI  - Copyright (c) 2023, Barkhane et al.
FAU - Barkhane, Zineb
AU  - Barkhane Z
AD  - Department of Neurology, Universite Hassan II de Casablanca, Casablanca, MAR.
FAU - Nimerta, Fnu
AU  - Nimerta F
AD  - Department of Medicine, Jinnah Sindh Medical University, Karachi, PAK.
FAU - Zulfiqar, Sualeha
AU  - Zulfiqar S
AD  - Department of Internal Medicine, Rawalpindi Medical University, Rawalpindi, PAK.
FAU - Dar, Saleha
AU  - Dar S
AD  - Department of Medicine, Louisiana State University Health Sciences Center, 
      Shreveport, USA.
FAU - Afzal, Muhammad Sohaib
AU  - Afzal MS
AD  - Department of Medicine, Louisiana State University Health Sciences Center, 
      Shreveport, USA.
FAU - Zaree, Amna
AU  - Zaree A
AD  - Department of Medicine, Shalamar Medical and Dental College, Lahore, PAK.
FAU - Adwani, Rahul
AU  - Adwani R
AD  - Department of Medicine, Dow University of Health Sciences, Karachi, PAK.
FAU - Palleti, Sujith K
AU  - Palleti SK
AD  - Department of Nephrology, Edward Hines Jr. Veterans Administration Hospital, 
      Hines, USA.
AD  - Department of Nephrology, Loyola University Medical Center, Maywood, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230530
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC10310541
OTO - NOTNLM
OT  - meta-analysis
OT  - mortality
OT  - predictors
OT  - pulmonary arterial hypertension
OT  - systemic sclerosis
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/07/03 13:05
MHDA- 2023/07/03 13:06
PMCR- 2023/05/30
CRDT- 2023/07/03 11:51
PHST- 2023/05/30 00:00 [accepted]
PHST- 2023/07/03 13:06 [medline]
PHST- 2023/07/03 13:05 [pubmed]
PHST- 2023/07/03 11:51 [entrez]
PHST- 2023/05/30 00:00 [pmc-release]
AID - 10.7759/cureus.39730 [doi]
PST - epublish
SO  - Cureus. 2023 May 30;15(5):e39730. doi: 10.7759/cureus.39730. eCollection 2023 
      May.