PMID- 37399684
OWN - NLM
STAT- MEDLINE
DCOM- 20230807
LR  - 20230807
IS  - 1878-3252 (Electronic)
IS  - 0946-672X (Linking)
VI  - 79
DP  - 2023 Sep
TI  - Zinc supplementation and cardiovascular disease risk factors: A GRADE-assessed 
      systematic review and dose-response meta-analysis.
PG  - 127244
LID - S0946-672X(23)00120-7 [pii]
LID - 10.1016/j.jtemb.2023.127244 [doi]
AB  - BACKGROUND AND OBJECTIVE: A deficit in zinc has been related to a higher 
      probability of developing cardiovascular diseases (CVDs). The anti-inflammatory 
      and anti-oxidative capabilities of zinc may have a wide range of therapeutic 
      impacts on CVDs. We conducted a comprehensive systematic review and meta-analysis 
      of the possible impacts that zinc supplementation may have on the risk factors 
      associated with CVDs. METHODS: To identify eligible randomized clinical trials 
      (RCTs) evaluating the effects of zinc supplementation on CVDs risk factors, 
      electronic databases including PubMed, Web of Science, and Scopus were 
      systematically searched up to January 2023. The heterogeneity of trials was 
      checked using the I(2) statistic. According to the heterogeneity tests, random 
      effects models were estimated and pooled data were defined as the weighted mean 
      difference (WMD) with a 95% confidence interval (CI). RESULTS: Of 23165 initial 
      records, 75 studies that met inclusion criteria were analyzed in this 
      meta-analysis. The pooled findings indicated the significant lowering effects of 
      zinc supplementation on triglycerides (TG), total cholesterol (TC), fasting blood 
      glucose (FBG), Hemoglobin A1C (HbA1C), Homeostatic Model Assessment for Insulin 
      Resistance (HOMA-IR), C-reactive protein (CRP), interleukin-6 (IL-6), Tumor 
      necrosis factor-alpha (TNF-alpha), nitric oxide (NO), malondialdehyde (MDA), total 
      antioxidant capacity (TAC), and glutathione (GSH), with no noticeable effects on 
      low-density lipoprotein (LDL), high-density lipoprotein (HDL), insulin, systolic 
      blood pressure (SBP), diastolic blood pressure (DBP), aspartate transaminase 
      (AST), and Alanine aminotransferase (ALT). CONCLUSION: Overall, zinc 
      supplementation may boost recognized coronary risk factors that contribute to the 
      development of CVDs. Future research should be conducted to bolster our results.
CI  - Copyright (c) 2023 Elsevier GmbH. All rights reserved.
FAU - Nazari, Matin
AU  - Nazari M
AD  - Department of Nutrition, Science and Research Branch, Islamic Azad University, 
      Tehran, Iran.
FAU - Ashtary-Larky, Damoon
AU  - Ashtary-Larky D
AD  - Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of 
      Medical Sciences, Ahvaz, Iran.
FAU - Nikbaf-Shandiz, Mahlagha
AU  - Nikbaf-Shandiz M
AD  - Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Goudarzi, Kian
AU  - Goudarzi K
AD  - Faculty of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran.
FAU - Bagheri, Reza
AU  - Bagheri R
AD  - Department of Exercise Physiology, University of Isfahan, Iran.
FAU - Dolatshahi, Sina
AU  - Dolatshahi S
AD  - Faculty of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran.
FAU - Omran, Hossein Salehi
AU  - Omran HS
AD  - Faculty of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran.
FAU - Amirani, Niusha
AU  - Amirani N
AD  - Faculty of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
FAU - Ghanavati, Matin
AU  - Ghanavati M
AD  - National Nutrition and Food Technology Research Institute, Shahid Beheshti 
      University of Medical Sciences, Tehran, Iran. Electronic address: 
      matina_844@yahoo.com.
FAU - Asbaghi, Omid
AU  - Asbaghi O
AD  - Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, 
      Iran; Student Research Committee, Shahid Beheshti University of Medical Sciences, 
      Tehran, Iran. Electronic address: omid.asbaghi@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20230615
PL  - Germany
TA  - J Trace Elem Med Biol
JT  - Journal of trace elements in medicine and biology : organ of the Society for 
      Minerals and Trace Elements (GMS)
JID - 9508274
RN  - J41CSQ7QDS (Zinc)
RN  - 0 (Blood Glucose)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Humans
MH  - *Dietary Supplements
MH  - *Cardiovascular Diseases
MH  - Zinc
MH  - Blood Glucose/metabolism
MH  - Triglycerides
OTO - NOTNLM
OT  - Cardiac function
OT  - Metabolic disease
OT  - Nutrition
OT  - Nutritional supplements
OT  - Zinc
COIS- Declaration of Competing Interest The authors declare no conflict of interest.
EDAT- 2023/07/04 01:05
MHDA- 2023/08/07 06:42
CRDT- 2023/07/03 18:03
PHST- 2023/04/25 00:00 [received]
PHST- 2023/06/11 00:00 [revised]
PHST- 2023/06/12 00:00 [accepted]
PHST- 2023/08/07 06:42 [medline]
PHST- 2023/07/04 01:05 [pubmed]
PHST- 2023/07/03 18:03 [entrez]
AID - S0946-672X(23)00120-7 [pii]
AID - 10.1016/j.jtemb.2023.127244 [doi]
PST - ppublish
SO  - J Trace Elem Med Biol. 2023 Sep;79:127244. doi: 10.1016/j.jtemb.2023.127244. Epub 
      2023 Jun 15.