PMID- 37399847
OWN - NLM
STAT- Publisher
LR  - 20230729
IS  - 1098-8785 (Electronic)
IS  - 0735-1631 (Linking)
DP  - 2023 Jul 29
TI  - Neurodevelopmental Outcomes of Preterm Infants Born <29 Weeks with 
      Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension: A Multicenter 
      Study.
LID - 10.1055/a-2121-8878 [doi]
AB  - OBJECTIVE:  This study aimed to determine neurodevelopmental outcomes of preterm 
      infants born at <29 weeks' gestational age (GA) with bronchopulmonary dysplasia 
      and pulmonary hypertension (BPD-PH) at 18 to 24 months' corrected age (CA). STUDY 
      DESIGN:  In this retrospective cohort study, preterm infants born at <29 weeks' 
      GA between January 2016 and December 2019, admitted to level 3 neonatal intensive 
      care units, who developed BPD and were evaluated at 18 to 24 months' CA in the 
      neonatal follow-up clinics were included. We compared demographic characteristics 
      and neurodevelopmental outcomes between the two groups: Group I: BPD with PH and 
      Group II: BPD with no PH, using univariate and multivariate regression models. 
      The primary outcome was a composite of death or neurodevelopmental impairment 
      (NDI). NDI was defined as any Bayley-III score < 85 on one or more of the 
      cognitive, motor, or language composite scores. RESULTS:  Of 366 eligible 
      infants, 116 (Group I [BPD-PH] =7, Group II [BPD with no PH] = 109) were lost to 
      follow-up. Of the remaining 250 infants, 51 in Group I and 199 in Group II were 
      followed at 18 to 24 months' CA. Group I and Group II had median (interquartile 
      range [IQR]) birthweights of 705 (325) and 815 g (317; p = 0.003) and median GAs 
      (IQR) were 25 (2) and 26 weeks (2; p = 0.015) respectively. Infants in the BPD-PH 
      group (Group I) were more likely to have mortality or NDI (adjusted odds ratio: 
      3.82; bootstrap 95% confidence interval; 1.44-40.87). CONCLUSION:  BPD-PH in 
      infants born at <29 weeks' GA is associated with increased odds of the composite 
      outcome of death or NDI at 18 to 24 months' CA. KEY POINTS: . Long-term 
      neurodevelopmental follow-up of preterm infants born <29 weeks' GA.. . 
      Association of neurodevelopmental outcomes with BPD-associated PH.. . Need for 
      longitudinal follow-up of children with BPD-associated PH..
CI  - Thieme. All rights reserved.
FAU - Thomas, Soumya R
AU  - Thomas SR
AD  - Department of Pediatrics, Cumming School of Medicine, University of Calgary, 
      Calgary, Alberta, Canada.
AD  - Neonatal Follow-up Clinic, Alberta Children's Hospital, Alberta Health Services, 
      Calgary, Alberta, Canada.
FAU - Jain, Sunil K
AU  - Jain SK
AD  - Division of Neonatology, Department of Pediatrics, University of Texas Medical 
      Branch, Galveston, Texas.
FAU - Murthy, Prashanth
AU  - Murthy P
AD  - Department of Pediatrics, Cumming School of Medicine, University of Calgary, 
      Calgary, Alberta, Canada.
AD  - Neonatal Follow-up Clinic, Alberta Children's Hospital, Alberta Health Services, 
      Calgary, Alberta, Canada.
FAU - Joseph, Chacko J
AU  - Joseph CJ
AD  - Department of Pediatrics, Cumming School of Medicine, University of Calgary, 
      Calgary, Alberta, Canada.
AD  - Neonatal Follow-up Clinic, Alberta Children's Hospital, Alberta Health Services, 
      Calgary, Alberta, Canada.
FAU - Soraisham, Amuchou
AU  - Soraisham A
AD  - Department of Pediatrics, Cumming School of Medicine, University of Calgary, 
      Calgary, Alberta, Canada.
AD  - Neonatal Follow-up Clinic, Alberta Children's Hospital, Alberta Health Services, 
      Calgary, Alberta, Canada.
AD  - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, 
      Alberta, Canada.
FAU - Tang, Selphee
AU  - Tang S
AD  - Neonatal Follow-up Clinic, Alberta Children's Hospital, Alberta Health Services, 
      Calgary, Alberta, Canada.
FAU - Dosani, Aliyah
AU  - Dosani A
AD  - School of Nursing and Midwifery, Faculty of Health, Community and Education, 
      Mount Royal University, Calgary, Alberta, Canada.
AD  - Department of Community Health Sciences, Cumming School of Medicine, University 
      of Calgary, Calgary, Alberta, Canada.
FAU - Lodha, Abhay
AU  - Lodha A
AD  - Department of Pediatrics, Cumming School of Medicine, University of Calgary, 
      Calgary, Alberta, Canada.
AD  - Neonatal Follow-up Clinic, Alberta Children's Hospital, Alberta Health Services, 
      Calgary, Alberta, Canada.
AD  - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, 
      Alberta, Canada.
AD  - Department of Community Health Sciences, Cumming School of Medicine, University 
      of Calgary, Calgary, Alberta, Canada.
LA  - eng
PT  - Journal Article
DEP - 20230729
PL  - United States
TA  - Am J Perinatol
JT  - American journal of perinatology
JID - 8405212
SB  - IM
COIS- None declared.
EDAT- 2023/07/04 01:05
MHDA- 2023/07/04 01:05
CRDT- 2023/07/03 19:13
PHST- 2023/07/04 01:05 [pubmed]
PHST- 2023/07/04 01:05 [medline]
PHST- 2023/07/03 19:13 [entrez]
AID - 10.1055/a-2121-8878 [doi]
PST - aheadofprint
SO  - Am J Perinatol. 2023 Jul 29. doi: 10.1055/a-2121-8878.