PMID- 37400394
OWN - NLM
STAT- MEDLINE
DCOM- 20230705
LR  - 20230705
IS  - 1007-3418 (Print)
IS  - 1007-3418 (Linking)
VI  - 31
IP  - 6
DP  - 2023 Jun 20
TI  - [Genetic susceptibility to drug-induced liver injury].
PG  - 653-658
LID - 10.3760/cma.j.cn501113-20230418-00172 [doi]
AB  - Drug-induced liver injury (DILI) risk prediction, diagnosis establishment, 
      clinical management, and all other aspects are facing great challenges. Although 
      the current understanding of its pathogenesis is still incomplete, research over 
      the past 20 years has shown that genetic susceptibility may play an important 
      role in the occurrence and development of DILI. In recent years, pharmacogenomics 
      studies have further revealed the association between human leukocyte antigen 
      (HLA) genes, some non-HLA genes, and hepatotoxicity from certain drugs. However, 
      due to the lack of well-designed, prospective, large-sample cohort validation and 
      low positive predictive values, there may still be some way to go before the 
      current results can be truly translated into clinical practice for precise 
      prediction and prevention of DILI risk.
FAU - Zhi, Y
AU  - Zhi Y
AD  - Renji Hospital, School of Medicine, Shanghai Jiao Tong University; Shanghai 
      Institute of Digestive Disease; Shanghai Research Center of Fatty Liver Disease, 
      Shanghai 200001, China.
FAU - Tang, J T
AU  - Tang JT
AD  - Renji Hospital, School of Medicine, Shanghai Jiao Tong University; Shanghai 
      Institute of Digestive Disease; Shanghai Research Center of Fatty Liver Disease, 
      Shanghai 200001, China.
FAU - Mao, Y M
AU  - Mao YM
AD  - Renji Hospital, School of Medicine, Shanghai Jiao Tong University; Shanghai 
      Institute of Digestive Disease; Shanghai Research Center of Fatty Liver Disease, 
      Shanghai 200001, China.
LA  - chi
GR  - 2022YFC3502101/National Key R&D Program of China/
GR  - 2017ZX09304016/Major Project of National Thirteenth Five Plan/
GR  - 81970513, 82270619/National Natural Science Foundation of China/
GR  - PY120-05/Clinical Research Innovation and Development Fund of Renji Hospital, 
      School of Medicine, Shanghai Jiao Tong University/
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Gan Zang Bing Za Zhi
JT  - Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of 
      hepatology
JID - 9710009
SB  - IM
MH  - Humans
MH  - Genetic Predisposition to Disease
MH  - Prospective Studies
MH  - Risk Factors
MH  - *Chemical and Drug Induced Liver Injury/genetics
MH  - *Drug-Related Side Effects and Adverse Reactions
MH  - Liver
OTO - NOTNLM
OT  - Drug-induced liver injury
OT  - Genetic susceptibility
OT  - Human leukocyte antigen
EDAT- 2023/07/04 01:05
MHDA- 2023/07/05 06:42
CRDT- 2023/07/03 22:46
PHST- 2023/07/05 06:42 [medline]
PHST- 2023/07/04 01:05 [pubmed]
PHST- 2023/07/03 22:46 [entrez]
AID - 10.3760/cma.j.cn501113-20230418-00172 [doi]
PST - ppublish
SO  - Zhonghua Gan Zang Bing Za Zhi. 2023 Jun 20;31(6):653-658. doi: 
      10.3760/cma.j.cn501113-20230418-00172.