PMID- 37400582
OWN - NLM
STAT- MEDLINE
DCOM- 20230918
LR  - 20231108
IS  - 1432-1246 (Electronic)
IS  - 0340-0131 (Linking)
VI  - 96
IP  - 8
DP  - 2023 Oct
TI  - Urine 2-hydroxyphenanthrene is associated with current asthma: evidence from 
      NHANES 2007-2012.
PG  - 1123-1136
LID - 10.1007/s00420-023-01994-5 [doi]
AB  - OBJECTIVE: The current study aims to explore the effects of nine urine 
      monohydroxy PAH metabolites (OHPAH) including 1-hydroxynaphthalene (1-OHNAP), 
      2-hydroxynaphthalene (2-OHNAP), 3-hydroxyfluorene (3-OHFLU), 9-hydroxyfluorene 
      (9-OHFLU), 1-hydroxyphenanthrene (1-OHPHE), 2-hydroxyphenanthrene (2-OHPHE), 
      3-hydroxyphenanthrene (3-OHPHE), and 1-hydroxypyrene (1-OHPYR) on current asthma 
      in people in the United States using a variety of statistical techniques. 
      METHODS: A cross-sectional examination of a subsample of 3804 adults aged >/=20 
      from the National Health and Nutrition Examination Survey (NHANES) was conducted 
      between 2007 and 2012. To investigate the relationship between urine OHPAHs 
      levels and current asthma, multivariate logistic regression, Bayesian kernel 
      machine regression (BKMR), and quantile g-computation (qgcomp) were utilized. 
      RESULTS: In the multivariate logistic regression model, after controlling for 
      confounders, urine 2-OHPHE was associated with current asthma in both male 
      (AOR = 7.17, 95% CI: 1.28-40.08) and female (AOR = 2.91, 95% CI: 1.06-8.01) 
      smokers. In the qgcomp analysis, 2-OHPHE (39.5%), 1-OHNAP (33.1%), and 2-OHNAP 
      (22.5%) were the major positive contributors to the risk of current asthma 
      (OR = 2.29, 95% CI: 0.99, 5.25), and in female smokers, 9-OHFLU (25.8%), 2-OHFLU 
      (21.5%), and 2-OHPHE (15.1%) were the major positive contributors (OR = 2.19, 95% 
      CI: 1.06, 4.47). The results of the BKMR model basically agreed with qgcomp 
      analysis. CONCLUSION: Our results demonstrate a strong association of urine 
      2-OHPHE with current asthma, and further longitudinal studies are needed to 
      understand the precise relationship between PAH exposure and current asthma risk.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Lu, Lingyi
AU  - Lu L
AD  - Xuhui District Center for Disease Control and Prevention, 200237, Shanghai, 
      China.
FAU - Mao, Tingfeng
AU  - Mao T
AD  - Xuhui District Center for Disease Control and Prevention, 200237, Shanghai, 
      China.
FAU - Xu, Rui
AU  - Xu R
AD  - Xuhui District Center for Disease Control and Prevention, 200237, Shanghai, 
      China.
FAU - Liu, Lanxia
AU  - Liu L
AD  - Xuhui District Center for Disease Control and Prevention, 200237, Shanghai, 
      China.
FAU - Qian, Jiefeng
AU  - Qian J
AD  - Xuhui District Center for Disease Control and Prevention, 200237, Shanghai, 
      China.
FAU - Yang, Kai
AU  - Yang K
AD  - Xuhui District Center for Disease Control and Prevention, 200237, Shanghai, 
      China.
FAU - Yuan, Anjie
AU  - Yuan A
AD  - Xuhui District Center for Disease Control and Prevention, 200237, Shanghai, 
      China.
FAU - Wang, Xinyue
AU  - Wang X
AD  - Xuhui District Center for Disease Control and Prevention, 200237, Shanghai, 
      China.
FAU - Ni, Rong
AU  - Ni R
AUID- ORCID: 0000-0002-0777-2930
AD  - Xuhui District Center for Disease Control and Prevention, 200237, Shanghai, 
      China. xhcdcpcl@163.com.
LA  - eng
PT  - Journal Article
DEP - 20230704
PL  - Germany
TA  - Int Arch Occup Environ Health
JT  - International archives of occupational and environmental health
JID - 7512134
RN  - 0 (Polycyclic Aromatic Hydrocarbons)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Humans
MH  - Male
MH  - Female
MH  - United States/epidemiology
MH  - Nutrition Surveys
MH  - Cross-Sectional Studies
MH  - Bayes Theorem
MH  - *Polycyclic Aromatic Hydrocarbons/urine
MH  - *Asthma/epidemiology
MH  - Biomarkers/analysis
OTO - NOTNLM
OT  - Asthma
OT  - BKMR
OT  - NHANES
OT  - Polycyclic aromatic hydrocarbon
OT  - qgcomp
EDAT- 2023/07/04 01:05
MHDA- 2023/09/18 12:42
CRDT- 2023/07/03 23:24
PHST- 2023/04/13 00:00 [received]
PHST- 2023/06/23 00:00 [accepted]
PHST- 2023/09/18 12:42 [medline]
PHST- 2023/07/04 01:05 [pubmed]
PHST- 2023/07/03 23:24 [entrez]
AID - 10.1007/s00420-023-01994-5 [pii]
AID - 10.1007/s00420-023-01994-5 [doi]
PST - ppublish
SO  - Int Arch Occup Environ Health. 2023 Oct;96(8):1123-1136. doi: 
      10.1007/s00420-023-01994-5. Epub 2023 Jul 4.