PMID- 37401190
OWN - NLM
STAT- MEDLINE
DCOM- 20230731
LR  - 20230815
IS  - 1748-1716 (Electronic)
IS  - 1748-1708 (Linking)
VI  - 238
IP  - 4
DP  - 2023 Aug
TI  - Inter-individual variability in redox and performance responses after antioxidant 
      supplementation: A randomized double blind crossover study.
PG  - e14017
LID - 10.1111/apha.14017 [doi]
AB  - AIM: We aimed to investigate the inter-individual variability in redox and 
      physiological responses of antioxidant-deficient subjects after antioxidant 
      supplementation. METHODS: Two hundred individuals were sorted by plasma vitamin C 
      levels. A low vitamin C group (n = 22) and a control group (n = 22) were compared 
      in terms of oxidative stress and performance. Subsequently, the low vitamin C 
      group received for 30 days vitamin C (1 g) or placebo, in randomized, 
      double-blind, crossover fashion, and the effects were examined through a 
      mixed-effects model, while individual responses were calculated. RESULTS: The low 
      vitamin C group exhibited lower vitamin C (-25 mumol/L; 95%CI[-31.7, -18.3]; 
      p < 0.001), higher F(2) -isoprostanes (+17.1 pg/mL; 95%CI[6.5, 27.7]; p = 0.002), 
      impaired VO(2max) (-8.2 mL/kg/min; 95%CI[-12.8, -3.6]; p < 0.001) and lower 
      isometric peak torque (-41.5 Nm; 95%CI[-61.8, -21.2]; p < 0.001) compared to the 
      control group. Regarding antioxidant supplementation, a significant treatment 
      effect was found in vitamin C (+11.6 mumol/L; 95%CI[6.8, 17.1], p < 0.001), F(2) 
      -isoprostanes (-13.7 pg/mL; 95%CI[-18.9, -8.4], p < 0.001), VO(2max) 
      (+5.4 mL/kg/min; 95%CI[2.7, 8.2], p = 0.001) and isometric peak torque (+18.7; 
      95%CI[11.8, 25.7 Nm], p < 0.001). The standard deviation for individual responses 
      (SDir) was greater than the smallest worthwhile change (SWC) for all variables 
      indicating meaningful inter-individual variability. When a minimal clinically 
      important difference (MCID) was set, inter-individual variability remained for 
      VO(2max) , but not for isometric peak torque. CONCLUSION: The proportion of 
      response was generally high after supplementation (82.9%-95.3%); however, a few 
      participants did not benefit from the treatment. This underlines the potential 
      need for personalized nutritional interventions in an exercise physiology 
      context.
CI  - (c) 2023 The Authors. Acta Physiologica published by John Wiley & Sons Ltd on 
      behalf of Scandinavian Physiological Society.
FAU - Margaritelis, Nikos V
AU  - Margaritelis NV
AUID- ORCID: 0000-0001-5119-427X
AD  - Department of Physical Education and Sports Science at Serres, Aristotle 
      University of Thessaloniki, Serres, Greece.
FAU - Nastos, George G
AU  - Nastos GG
AD  - Department of Physical Education and Sports Science at Serres, Aristotle 
      University of Thessaloniki, Serres, Greece.
FAU - Vasileiadou, Olga
AU  - Vasileiadou O
AD  - Department of Physical Education and Sports Science at Serres, Aristotle 
      University of Thessaloniki, Serres, Greece.
FAU - Chatzinikolaou, Panagiotis N
AU  - Chatzinikolaou PN
AD  - Department of Physical Education and Sports Science at Serres, Aristotle 
      University of Thessaloniki, Serres, Greece.
FAU - Theodorou, Anastasios A
AU  - Theodorou AA
AD  - Department of Life Sciences, School of Sciences, European University Cyprus, 
      Nicosia, Cyprus.
FAU - Paschalis, Vassilis
AU  - Paschalis V
AD  - School of Physical Education and Sport Science, National and Kapodistrian 
      University of Athens, Athens, Greece.
FAU - Vrabas, Ioannis S
AU  - Vrabas IS
AD  - Department of Physical Education and Sports Science at Serres, Aristotle 
      University of Thessaloniki, Serres, Greece.
FAU - Kyparos, Antonios
AU  - Kyparos A
AD  - Department of Physical Education and Sports Science at Serres, Aristotle 
      University of Thessaloniki, Serres, Greece.
FAU - Fatouros, Ioannis G
AU  - Fatouros IG
AD  - Department of Physical Education and Sport Sciences, University of Thessaly, 
      Trikala, Greece.
FAU - Nikolaidis, Michalis G
AU  - Nikolaidis MG
AD  - Department of Physical Education and Sports Science at Serres, Aristotle 
      University of Thessaloniki, Serres, Greece.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20230703
PL  - England
TA  - Acta Physiol (Oxf)
JT  - Acta physiologica (Oxford, England)
JID - 101262545
RN  - 0 (Antioxidants)
RN  - PQ6CK8PD0R (Ascorbic Acid)
RN  - 0 (Vitamins)
RN  - 0 (Isoprostanes)
SB  - IM
MH  - Humans
MH  - *Antioxidants/pharmacology/metabolism
MH  - Cross-Over Studies
MH  - *Ascorbic Acid/pharmacology/therapeutic use
MH  - Oxidation-Reduction
MH  - Oxidative Stress
MH  - Vitamins/pharmacology
MH  - Double-Blind Method
MH  - Dietary Supplements
MH  - Isoprostanes/pharmacology
OTO - NOTNLM
OT  - antioxidants
OT  - deficiency
OT  - inter-individual variability
OT  - oxidative stress
OT  - personalized
OT  - precision
OT  - vitamin C
EDAT- 2023/07/04 06:42
MHDA- 2023/07/31 06:42
CRDT- 2023/07/04 02:43
PHST- 2023/06/14 00:00 [revised]
PHST- 2023/02/13 00:00 [received]
PHST- 2023/06/19 00:00 [accepted]
PHST- 2023/07/31 06:42 [medline]
PHST- 2023/07/04 06:42 [pubmed]
PHST- 2023/07/04 02:43 [entrez]
AID - 10.1111/apha.14017 [doi]
PST - ppublish
SO  - Acta Physiol (Oxf). 2023 Aug;238(4):e14017. doi: 10.1111/apha.14017. Epub 2023 
      Jul 3.