PMID- 37401392
OWN - NLM
STAT- MEDLINE
DCOM- 20240308
LR  - 20240308
IS  - 1473-5849 (Electronic)
IS  - 0955-8810 (Linking)
VI  - 35
IP  - 2-3
DP  - 2024 Apr 1
TI  - Additive effect of histamine and muscimol upon induction of antinociceptive and 
      antidepressant effects in mice.
PG  - 55-65
LID - 10.1097/FBP.0000000000000729 [doi]
AB  - We investigated the effects of histamine and GABA A receptor agents on pain and 
      depression-like behaviors and their interaction using a tail-flick test and the 
      forced swimming test (FST) in male mice. Our data revealed that intraperitoneal 
      administration of muscimol (0.12 and 0.25 mg/kg) increased the percentage of 
      maximum possible effect (%MPE) and area under the curve (AUC) of %MPE, indicating 
      an antinociceptive response. Intraperitoneal injection of bicuculline (0.5 and 
      1 mg/kg) decreased %MPE and AUC of %MPE, suggesting hyperalgesia. Moreover, 
      muscimol by reducing the immobility time of the FST elicited an 
      antidepressant-like response but bicuculline by enhancing the immobility time of 
      the FST caused a depressant-like response. Intracerebroventricular (i.c.v.) 
      microinjection of histamine (5 microg/mouse) enhanced %MPE and AUC of %MPE. i.c.v. 
      infusion of histamine (2.5 and 5 microg/mouse) decreased immobility time in the FST. 
      Co-administration of different doses of histamine along with a sub-threshold dose 
      of muscimol potentiated antinociceptive and antidepressant-like responses 
      produced by histamine. Cotreatment of different doses of histamine plus a 
      noneffective dose of bicuculline reversed antinociception and antidepressant-like 
      effects elicited by histamine. Cotreatment of histamine, muscimol, and 
      bicuculline reversed antinociceptive and antidepressant-like behaviors induced by 
      the drugs. The results demonstrated additive antinociceptive and 
      antidepressant-like effects between histamine and muscimol in mice. In 
      conclusion, our results indicated an interaction between the histaminergic and 
      GABAergic systems in the modulation of pain and depression-like behaviors.
CI  - Copyright (c) 2023 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Baghani, Matin
AU  - Baghani M
AD  - Department of Physiology, Faculty of Medicine, Tehran Medical Sciences, Islamic 
      Azad University.
AD  - Department of Pharmacology, School of Medicine, Tehran University of Medical 
      Sciences.
FAU - Fathalizade, Farzan
AU  - Fathalizade F
AD  - Department of Physiology, Faculty of Medicine, Tehran Medical Sciences, Islamic 
      Azad University.
AD  - Department of Pharmacology, School of Medicine, Tehran University of Medical 
      Sciences.
FAU - Khakpai, Fatemeh
AU  - Khakpai F
AD  - Department of Physiology, Faculty of Medicine, Tehran Medical Sciences, Islamic 
      Azad University.
FAU - Fazli-Tabaei, Soheila
AU  - Fazli-Tabaei S
AD  - Department of Physiology, Faculty of Medicine, Tehran Medical Sciences, Islamic 
      Azad University.
FAU - Zarrindast, Mohammad-Reza
AU  - Zarrindast MR
AD  - Department of Pharmacology, School of Medicine, Tehran University of Medical 
      Sciences.
AD  - Iranian National Center for Addiction Studies, Tehran University of Medical 
      Sciences.
AD  - Department of Neuroendocrinology, Endocrinology and Metabolism Clinical Sciences 
      Institute, Tehran University of Medical Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20230526
PL  - England
TA  - Behav Pharmacol
JT  - Behavioural pharmacology
JID - 9013016
RN  - 2763-96-4 (Muscimol)
RN  - 820484N8I3 (Histamine)
RN  - Y37615DVKC (Bicuculline)
RN  - 0 (Antidepressive Agents)
RN  - 0 (Analgesics)
SB  - IM
MH  - Mice
MH  - Male
MH  - Animals
MH  - Muscimol/pharmacology
MH  - *Histamine/pharmacology
MH  - Bicuculline/pharmacology
MH  - *Antidepressive Agents/pharmacology
MH  - Swimming
MH  - Analgesics/pharmacology
MH  - Pain/drug therapy
EDAT- 2023/07/04 06:42
MHDA- 2024/03/08 06:42
CRDT- 2023/07/04 04:12
PHST- 2024/03/08 06:42 [medline]
PHST- 2023/07/04 06:42 [pubmed]
PHST- 2023/07/04 04:12 [entrez]
AID - 00008877-990000000-00043 [pii]
AID - 10.1097/FBP.0000000000000729 [doi]
PST - ppublish
SO  - Behav Pharmacol. 2024 Apr 1;35(2-3):55-65. doi: 10.1097/FBP.0000000000000729. 
      Epub 2023 May 26.