PMID- 37401890
OWN - NLM
STAT- MEDLINE
DCOM- 20230710
LR  - 20230727
IS  - 1530-6860 (Electronic)
IS  - 0892-6638 (Linking)
VI  - 37
IP  - 8
DP  - 2023 Aug
TI  - A novel long noncoding RNA-lncRNA-AABR07066529.3 alleviates inflammation, 
      apoptosis, and pyroptosis by inhibiting MyD88 in lipopolysaccharide-induced 
      myocardial depression.
PG  - e23063
LID - 10.1096/fj.202201680R [doi]
AB  - Sepsis-induced myocardial depression (SIMD) is common in pediatric intensive care 
      units and seriously threatens children's health. Recently, long noncoding RNAs 
      (lncRNAs) have been showed to play important roles in various diseases; however, 
      its role in SIMD is unclear. In this study, we used lipopolysaccharide 
      (LPS)-treated rats and H9c2 cardiomyocytes to mimic SIMD in vivo and in vitro. We 
      found that the expression of a novel lncRNA, we named lncRNA-AABR07066529.3, was 
      elevated in LPS-induced rat heart tissue and H9c2 cardiomyocytes. In addition, 
      LPS-induced inflammation, apoptosis, and pyroptosis were significantly 
      exacerbated after lncRNA-AABR07066529.3 knockdown. Moreover, we found that 
      myeloid differentiation factor 88 (MyD88) was upregulated in LPS-treated groups 
      and was inhibited by lncRNA-AABR07066529.3. Besides, MyD88 knockdown abolished 
      lncRNA-AABR07066529.3 silencing effects on inflammation, apoptosis, and 
      pyroptosis induced by LPS in H9c2 cardiomyocytes. In our study, we found 
      lncRNA-AABR07066529.3 exerted protective effects on LPS-induced cardiomyocytes by 
      regulating MyD88 and might serve as a potential treatment target for SIMD.
CI  - (c) 2023 The Authors. The FASEB Journal published by Wiley Periodicals LLC on 
      behalf of Federation of American Societies for Experimental Biology.
FAU - Wen, Ri
AU  - Wen R
AUID- ORCID: 0000-0002-7974-2132
AD  - Department of Pediatrics, PICU, Shengjing Hospital of China Medical University, 
      Shenyang, China.
FAU - Zhang, Tie-Ning
AU  - Zhang TN
AUID- ORCID: 0000-0003-4954-5370
AD  - Department of Pediatrics, PICU, Shengjing Hospital of China Medical University, 
      Shenyang, China.
FAU - Zhang, Tao
AU  - Zhang T
AUID- ORCID: 0000-0001-5341-8249
AD  - Department of Pediatrics, PICU, Shengjing Hospital of China Medical University, 
      Shenyang, China.
FAU - Tong, Yu-Jing
AU  - Tong YJ
AUID- ORCID: 0000-0002-9870-8810
AD  - Department of Pediatrics, PICU, Shengjing Hospital of China Medical University, 
      Shenyang, China.
FAU - Song, Wen-Liang
AU  - Song WL
AUID- ORCID: 0000-0003-2389-7204
AD  - Department of Pediatrics, PICU, Shengjing Hospital of China Medical University, 
      Shenyang, China.
FAU - Liu, Yong-Ping
AU  - Liu YP
AUID- ORCID: 0009-0005-5866-8251
AD  - Department of Pediatrics, PICU, Shengjing Hospital of China Medical University, 
      Shenyang, China.
FAU - Yang, Ni
AU  - Yang N
AUID- ORCID: 0000-0003-0167-5205
AD  - Department of Pediatrics, PICU, Shengjing Hospital of China Medical University, 
      Shenyang, China.
FAU - Liu, Chun-Feng
AU  - Liu CF
AUID- ORCID: 0000-0001-5360-616X
AD  - Department of Pediatrics, PICU, Shengjing Hospital of China Medical University, 
      Shenyang, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - FASEB J
JT  - FASEB journal : official publication of the Federation of American Societies for 
      Experimental Biology
JID - 8804484
RN  - 0 (Lipopolysaccharides)
RN  - 0 (MicroRNAs)
RN  - 0 (Myeloid Differentiation Factor 88)
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (Myd88 protein, rat)
SB  - IM
MH  - Animals
MH  - Rats
MH  - Apoptosis
MH  - *Cardiomyopathies/metabolism
MH  - Depression
MH  - Inflammation/chemically induced/genetics/metabolism
MH  - Lipopolysaccharides/pharmacology
MH  - *MicroRNAs/genetics
MH  - Myeloid Differentiation Factor 88/genetics/metabolism
MH  - Myocytes, Cardiac/metabolism
MH  - Pyroptosis/genetics
MH  - *RNA, Long Noncoding/genetics/metabolism
OTO - NOTNLM
OT  - MyD88
OT  - apoptosis
OT  - endotoxemia
OT  - inflammation
OT  - long noncoding RNAs
OT  - myocardial depression
OT  - pyroptosis
OT  - sepsis
EDAT- 2023/07/04 13:08
MHDA- 2023/07/06 06:42
CRDT- 2023/07/04 10:04
PHST- 2023/05/27 00:00 [revised]
PHST- 2022/10/13 00:00 [received]
PHST- 2023/06/15 00:00 [accepted]
PHST- 2023/07/06 06:42 [medline]
PHST- 2023/07/04 13:08 [pubmed]
PHST- 2023/07/04 10:04 [entrez]
AID - 10.1096/fj.202201680R [doi]
PST - ppublish
SO  - FASEB J. 2023 Aug;37(8):e23063. doi: 10.1096/fj.202201680R.