PMID- 37402143
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230721
IS  - 1929-0748 (Print)
IS  - 1929-0748 (Electronic)
IS  - 1929-0748 (Linking)
VI  - 12
DP  - 2023 Jul 4
TI  - Dynamic Modelling of Mental Resilience in Young Adults: Protocol for a 
      Longitudinal Observational Study (DynaM-OBS).
PG  - e39817
LID - 10.2196/39817 [doi]
LID - e39817
AB  - BACKGROUND: Stress-related mental disorders are highly prevalent and pose a 
      substantial burden on individuals and society. Improving strategies for the 
      prevention and treatment of mental disorders requires a better understanding of 
      their risk and resilience factors. This multicenter study aims to contribute to 
      this endeavor by investigating psychological resilience in healthy but 
      susceptible young adults over 9 months. Resilience is conceptualized in this 
      study as the maintenance of mental health or quick recovery from mental health 
      perturbations upon exposure to stressors, assessed longitudinally via frequent 
      monitoring of stressors and mental health. OBJECTIVE: This study aims to 
      investigate the factors predicting mental resilience and adaptive processes and 
      mechanisms contributing to mental resilience and to provide a methodological and 
      evidence-based framework for later intervention studies. METHODS: In a 
      multicenter setting, across 5 research sites, a sample with a total target size 
      of 250 young male and female adults was assessed longitudinally over 9 months. 
      Participants were included if they reported at least 3 past stressful life events 
      and an elevated level of (internalizing) mental health problems but were not 
      presently affected by any mental disorder other than mild depression. At 
      baseline, sociodemographic, psychological, neuropsychological, structural, and 
      functional brain imaging; salivary cortisol and alpha-amylase levels; and 
      cardiovascular data were acquired. In a 6-month longitudinal phase 1, stressor 
      exposure, mental health problems, and perceived positive appraisal were monitored 
      biweekly in a web-based environment, while ecological momentary assessments and 
      ecological physiological assessments took place once per month for 1 week, using 
      mobile phones and wristbands. In a subsequent 3-month longitudinal phase 2, 
      web-based monitoring was reduced to once a month, and psychological resilience 
      and risk factors were assessed again at the end of the 9-month period. In 
      addition, samples for genetic, epigenetic, and microbiome analyses were collected 
      at baseline and at months 3 and 6. As an approximation of resilience, an 
      individual stressor reactivity score will be calculated. Using regularized 
      regression methods, network modeling, ordinary differential equations, 
      landmarking methods, and neural net-based methods for imputation and dimension 
      reduction, we will identify the predictors and mechanisms of stressor reactivity 
      and thus be able to identify resilience factors and mechanisms that facilitate 
      adaptation to stressors. RESULTS: Participant inclusion began in October 2020, 
      and data acquisition was completed in June 2022. A total of 249 participants were 
      assessed at baseline, 209 finished longitudinal phase 1, and 153 finished 
      longitudinal phase 2. CONCLUSIONS: The Dynamic Modelling of 
      Resilience-Observational Study provides a methodological framework and data set 
      to identify predictors and mechanisms of mental resilience, which are intended to 
      serve as an empirical foundation for future intervention studies. INTERNATIONAL 
      REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/39817.
CI  - (c)Carolin Wackerhagen, Ilya M Veer, Judith M C van Leeuwen, Zala Reppmann, Antje 
      Riepenhausen, Sophie A Bogemann, Netali Mor, Lara M C Puhlmann, Aleksandra 
      Usciƚko, Matthias Zerban, Julian Mituniewicz, Avigail Lerner, Kenneth S L Yuen, 
      Goran Kober, Marta A Marciniak, Shakoor Pooseh, Jeroen Weermeijer, Alejandro 
      Arias-Vasquez, Harald Binder, Walter de Raedt, Birgit Kleim, Inez Myin-Germeys, 
      Karin Roelofs, Jens Timmer, Oliver Tuscher, Talma Hendler, Dorota Kobylinska, 
      Erno J Hermans, Raffael Kalisch, Henrik Walter. Originally published in JMIR 
      Research Protocols (https://www.researchprotocols.org), 04.07.2023.
FAU - Wackerhagen, Carolin
AU  - Wackerhagen C
AUID- ORCID: 0000-0002-5689-3472
AD  - Research Division of Mind and Brain, Department of Psychiatry and Psychotherapy, 
      Charite Campus Mitte, Charite - Universitatsmedizin Berlin, Corporate Member of 
      Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of 
      Health, Berlin, Germany.
FAU - Veer, Ilya M
AU  - Veer IM
AUID- ORCID: 0000-0002-6733-3593
AD  - Research Division of Mind and Brain, Department of Psychiatry and Psychotherapy, 
      Charite Campus Mitte, Charite - Universitatsmedizin Berlin, Corporate Member of 
      Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of 
      Health, Berlin, Germany.
AD  - Department of Developmental Psychology, University of Amsterdam, Amsterdam, 
      Netherlands.
FAU - van Leeuwen, Judith M C
AU  - van Leeuwen JMC
AUID- ORCID: 0000-0002-7750-1255
AD  - Donders Institute for Brain, Cognition, and Behaviour, Radboud University, 
      Nijmegen, Netherlands.
FAU - Reppmann, Zala
AU  - Reppmann Z
AUID- ORCID: 0000-0001-8633-9651
AD  - Research Division of Mind and Brain, Department of Psychiatry and Psychotherapy, 
      Charite Campus Mitte, Charite - Universitatsmedizin Berlin, Corporate Member of 
      Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of 
      Health, Berlin, Germany.
FAU - Riepenhausen, Antje
AU  - Riepenhausen A
AUID- ORCID: 0000-0001-8749-5349
AD  - Research Division of Mind and Brain, Department of Psychiatry and Psychotherapy, 
      Charite Campus Mitte, Charite - Universitatsmedizin Berlin, Corporate Member of 
      Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of 
      Health, Berlin, Germany.
AD  - Faculty of Philosophy, Berlin School of Mind and Brain, Humboldt-Universitat zu 
      Berlin, Berlin, Germany.
FAU - Bogemann, Sophie A
AU  - Bogemann SA
AUID- ORCID: 0000-0001-9382-0769
AD  - Donders Institute for Brain, Cognition, and Behaviour, Radboud University, 
      Nijmegen, Netherlands.
FAU - Mor, Netali
AU  - Mor N
AUID- ORCID: 0000-0002-3759-5680
AD  - Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Puhlmann, Lara M C
AU  - Puhlmann LMC
AUID- ORCID: 0000-0002-0870-8770
AD  - Leibniz Institute for Resilience Research, Mainz, Germany.
AD  - Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
FAU - Usciƚko, Aleksandra
AU  - Usciƚko A
AUID- ORCID: 0000-0002-0001-7190
AD  - Faculty of Psychology, University of Warsaw, Warsaw, Poland.
FAU - Zerban, Matthias
AU  - Zerban M
AUID- ORCID: 0000-0002-2684-3271
AD  - Neuroimaging Center, Focus Program Translational Neuroscience, Johannes Gutenberg 
      University Medical Center, Mainz, Germany.
FAU - Mituniewicz, Julian
AU  - Mituniewicz J
AUID- ORCID: 0000-0002-9717-5784
AD  - Faculty of Psychology, University of Warsaw, Warsaw, Poland.
FAU - Lerner, Avigail
AU  - Lerner A
AUID- ORCID: 0009-0003-0081-5912
AD  - Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
AD  - Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
FAU - Yuen, Kenneth S L
AU  - Yuen KSL
AUID- ORCID: 0000-0002-9465-9070
AD  - Leibniz Institute for Resilience Research, Mainz, Germany.
AD  - Neuroimaging Center, Focus Program Translational Neuroscience, Johannes Gutenberg 
      University Medical Center, Mainz, Germany.
FAU - Kober, Goran
AU  - Kober G
AUID- ORCID: 0000-0001-7038-0860
AD  - Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical 
      Center, University of Freiburg, Freiburg, Germany.
AD  - Freiburg Center for Data Analysis and Modelling, University of Freiburg, 
      Freiburg, Germany.
FAU - Marciniak, Marta A
AU  - Marciniak MA
AUID- ORCID: 0000-0003-4301-3269
AD  - Division of Experimental Psychopathology and Psychotherapy, Department of 
      Psychology, University of Zurich, Zurich, Switzerland.
AD  - Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric 
      University Hospital, University of Zurich, Zurich, Switzerland.
FAU - Pooseh, Shakoor
AU  - Pooseh S
AUID- ORCID: 0000-0002-5441-9507
AD  - Freiburg Center for Data Analysis and Modelling, University of Freiburg, 
      Freiburg, Germany.
FAU - Weermeijer, Jeroen
AU  - Weermeijer J
AUID- ORCID: 0000-0002-6288-795X
AD  - Center for Contextual Psychiatry, Department of Neurosciences, Katholieke 
      Universiteit Leuven, Leuven, Belgium.
FAU - Arias-Vasquez, Alejandro
AU  - Arias-Vasquez A
AUID- ORCID: 0000-0002-4786-0169
AD  - Donders Institute for Brain, Cognition, and Behaviour, Radboud University, 
      Nijmegen, Netherlands.
FAU - Binder, Harald
AU  - Binder H
AUID- ORCID: 0000-0002-5666-8662
AD  - Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical 
      Center, University of Freiburg, Freiburg, Germany.
AD  - Freiburg Center for Data Analysis and Modelling, University of Freiburg, 
      Freiburg, Germany.
FAU - de Raedt, Walter
AU  - de Raedt W
AUID- ORCID: 0000-0002-7117-7976
AD  - Stichting imec Nederland, Holst Centre, Eindhoven, Netherlands.
FAU - Kleim, Birgit
AU  - Kleim B
AUID- ORCID: 0000-0001-9114-2917
AD  - Division of Experimental Psychopathology and Psychotherapy, Department of 
      Psychology, University of Zurich, Zurich, Switzerland.
AD  - Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric 
      University Hospital, University of Zurich, Zurich, Switzerland.
FAU - Myin-Germeys, Inez
AU  - Myin-Germeys I
AUID- ORCID: 0000-0002-3731-4930
AD  - Center for Contextual Psychiatry, Department of Neurosciences, Katholieke 
      Universiteit Leuven, Leuven, Belgium.
FAU - Roelofs, Karin
AU  - Roelofs K
AUID- ORCID: 0000-0002-8863-8978
AD  - Donders Institute for Brain, Cognition, and Behaviour, Radboud University, 
      Nijmegen, Netherlands.
AD  - Behavioural Science Institute, Radboud University, Nijmegen, Netherlands.
FAU - Timmer, Jens
AU  - Timmer J
AUID- ORCID: 0000-0003-4517-1383
AD  - Freiburg Center for Data Analysis and Modelling, University of Freiburg, 
      Freiburg, Germany.
AD  - Institute of Physics, University of Freiburg, Freiburg, Germany.
AD  - Centre for Biological Signalling Studies and Centre for Integrative Biological 
      Signalling Studies, University of Freiburg, Freiburg, Germany.
FAU - Tuscher, Oliver
AU  - Tuscher O
AUID- ORCID: 0000-0002-4023-5301
AD  - Leibniz Institute for Resilience Research, Mainz, Germany.
AD  - Department of Psychiatry and Psychotherapy, Johannes Gutenberg University Medical 
      Center, Mainz, Germany.
FAU - Hendler, Talma
AU  - Hendler T
AUID- ORCID: 0000-0002-4182-4335
AD  - Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
AD  - Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
AD  - School of Psychological Science, Tel Aviv University, Tel Aviv, Israel.
FAU - Kobylinska, Dorota
AU  - Kobylinska D
AUID- ORCID: 0000-0003-0184-2595
AD  - Faculty of Psychology, University of Warsaw, Warsaw, Poland.
FAU - Hermans, Erno J
AU  - Hermans EJ
AUID- ORCID: 0000-0003-1339-8639
AD  - Donders Institute for Brain, Cognition, and Behaviour, Radboud University, 
      Nijmegen, Netherlands.
FAU - Kalisch, Raffael
AU  - Kalisch R
AUID- ORCID: 0000-0002-9503-7601
AD  - Leibniz Institute for Resilience Research, Mainz, Germany.
AD  - Neuroimaging Center, Focus Program Translational Neuroscience, Johannes Gutenberg 
      University Medical Center, Mainz, Germany.
FAU - Walter, Henrik
AU  - Walter H
AUID- ORCID: 0000-0002-9403-6121
AD  - Research Division of Mind and Brain, Department of Psychiatry and Psychotherapy, 
      Charite Campus Mitte, Charite - Universitatsmedizin Berlin, Corporate Member of 
      Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of 
      Health, Berlin, Germany.
AD  - Faculty of Philosophy, Berlin School of Mind and Brain, Humboldt-Universitat zu 
      Berlin, Berlin, Germany.
LA  - eng
PT  - Journal Article
DEP - 20230704
PL  - Canada
TA  - JMIR Res Protoc
JT  - JMIR research protocols
JID - 101599504
PMC - PMC10354714
OTO - NOTNLM
OT  - ecological momentary assessment
OT  - longitudinal
OT  - mental health
OT  - mobile phone
OT  - neuroimaging
OT  - prospective
OT  - resilience
OT  - resilience factors
OT  - stress
OT  - stress disorders
OT  - stressor reactivity
COIS- Conflicts of Interest: RK receives advisory honoraria from JoyVentures, Herzlia, 
      Israel. All other authors declare that they have no conflicts of interest.
EDAT- 2023/07/04 13:08
MHDA- 2023/07/04 13:09
PMCR- 2023/07/04
CRDT- 2023/07/04 11:53
PHST- 2022/05/25 00:00 [received]
PHST- 2022/12/12 00:00 [accepted]
PHST- 2022/12/01 00:00 [revised]
PHST- 2023/07/04 13:09 [medline]
PHST- 2023/07/04 13:08 [pubmed]
PHST- 2023/07/04 11:53 [entrez]
PHST- 2023/07/04 00:00 [pmc-release]
AID - v12i1e39817 [pii]
AID - 10.2196/39817 [doi]
PST - epublish
SO  - JMIR Res Protoc. 2023 Jul 4;12:e39817. doi: 10.2196/39817.