PMID- 37403032
OWN - NLM
STAT- MEDLINE
DCOM- 20230719
LR  - 20230719
IS  - 1520-6882 (Electronic)
IS  - 0003-2700 (Linking)
VI  - 95
IP  - 28
DP  - 2023 Jul 18
TI  - High-Sensitivity, Low-Field (19)F-MRI Approach Using High Manganese Ferrite 
      Concentrations.
PG  - 10572-10579
LID - 10.1021/acs.analchem.3c00379 [doi]
AB  - Fluorine-19 ((19)F) MRI ((19)F-MRI) is a promising method for quantifying 
      biomedical research and clinical applications without background interference. 
      Nevertheless, dependency on high-field MRI systems limits the applicability of 
      (19)F-MRI. Low-field MRI systems are more common than high-field MRI systems. 
      Hence, developing (19)F-MRI at low-field MRI devices can promote the (19)F-MRI 
      translation in medical diagnosis. The detection sensitivity of fluorine agents is 
      critical in (19)F-MRI. Reduction of the (19)F spin-lattice relaxation time (T(1)) 
      enables an improved detection sensitivity while requiring ultrashort echo time 
      (UTE) imaging methods to reduce the negative spin-spin relaxation (T(2)) decay 
      effect. However, conventional UTE sequences require hardware with high 
      performance. Herein, we introduce the k-space scaling imaging (KSSI) MRI sequence 
      that accomplishes sampling k-space with variable scales to implement 
      hardware-friendly UTE (19)F-MRI compatible with low-field MRI systems. We 
      implemented experiments with swine bone, a perfluorooctyl bromide (PFOB) phantom, 
      and one tumor-bearing mouse on two self-customized low-field MRI systems. The 
      swine bone imaging validated the ultrashort TE of KSSI. Under high concentrations 
      of manganese ferrite, a high signal-to-noise ratio was shown in the imaging of a 
      fluorine atom concentration of 658 mM, which indicated high-sensitivity detection 
      of KSSI. Moreover, the KSSI sequence exhibited a 7.1 times signal-to-noise ratio 
      of spin echo sequence on the PFOB phantom imaging with a fluorine atom 
      concentration of 3.29 M. Additionally, the various concentrations of the PFOB 
      phantom imaging revealed quantifiable capacity. Finally, the (1)H/(19)F imaging 
      was implemented with KSSI on one tumor-bearing mouse. This method provides the 
      potential for clinical translation of fluorine probes at low-field MRI systems.
FAU - Cao, Yupeng
AU  - Cao Y
AUID- ORCID: 0000-0002-2648-6497
AD  - National Center for Nanoscience and Technology, Beijing 100190, China.
FAU - Zhou, Xiaohan
AU  - Zhou X
AUID- ORCID: 0009-0001-9287-2492
AD  - National Center for Nanoscience and Technology, Beijing 100190, China.
AD  - School of Future Technology, University of Chinese Academy of Sciences, Beijing 
      100049, China.
FAU - Liu, Xiaoli
AU  - Liu X
AUID- ORCID: 0000-0002-2585-7559
AD  - Institute of Regenerative and Reconstructive Medicine, Med-X Institute, First 
      Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China.
FAU - Yang, Mei
AU  - Yang M
AD  - State Key Laboratory of Biochemical Engineering, Institute of Process 
      Engineering, Chinese Academy of Sciences, Beijing 100190, China.
FAU - Liu, Wentao
AU  - Liu W
AUID- ORCID: 0000-0001-7115-0282
AD  - National Center for Nanoscience and Technology, Beijing 100190, China.
FAU - Han, Dong
AU  - Han D
AUID- ORCID: 0000-0002-5527-4389
AD  - National Center for Nanoscience and Technology, Beijing 100190, China.
AD  - School of Future Technology, University of Chinese Academy of Sciences, Beijing 
      100049, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230704
PL  - United States
TA  - Anal Chem
JT  - Analytical chemistry
JID - 0370536
RN  - Q1D0Q7R4D9 (perflubron)
RN  - 0 (manganese ferrite)
RN  - 284SYP0193 (Fluorine)
RN  - 0 (Fluorocarbons)
SB  - IM
MH  - Animals
MH  - Mice
MH  - Swine
MH  - *Fluorine
MH  - Magnetic Resonance Imaging/methods
MH  - *Fluorocarbons
EDAT- 2023/07/05 01:06
MHDA- 2023/07/19 06:42
CRDT- 2023/07/04 23:36
PHST- 2023/07/19 06:42 [medline]
PHST- 2023/07/05 01:06 [pubmed]
PHST- 2023/07/04 23:36 [entrez]
AID - 10.1021/acs.analchem.3c00379 [doi]
PST - ppublish
SO  - Anal Chem. 2023 Jul 18;95(28):10572-10579. doi: 10.1021/acs.analchem.3c00379. 
      Epub 2023 Jul 4.