PMID- 3740308
OWN - NLM
STAT- MEDLINE
DCOM- 19860917
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 251
IP  - 2 Pt 2
DP  - 1986 Aug
TI  - Increased hexokinase activity in forebrain of water-deprived and diabetes 
      insipidus rats.
PG  - R268-73
AB  - Metabolic studies using the 2-[14C]deoxy-D-glucose and cytochrome oxidase 
      techniques have demonstrated changes in the activity of central sites associated 
      with the hypothalamoneurohypophysial system in water-deprived (WD) and diabetes 
      insipidus (DI) rats. Another method that may be used as an index of metabolic 
      activity in discrete regions of the central nervous system is the measurement of 
      hexokinase (HK) activity. This study describes changes in metabolic activity, as 
      measured by HK histochemistry, in regions of the forebrain of WD and DI rats. 
      Significant increases in HK activity measured by densitometric analysis were 
      observed in the magnocellular component of the paraventricular nucleus of the 
      hypothalamus, supraoptic nucleus, nucleus circularis, and neurohypophysis of WD 
      and DI rats. In addition, increased HK activity was observed in the preoptic area 
      and subfornical organ of DI rats. These data demonstrate that metabolic changes 
      occur in the forebrain of WD and DI rats within structures involved in body fluid 
      regulation. The present study also demonstrates that HK histochemistry may be 
      used as a marker of metabolic activity in discrete regions of the central nervous 
      system.
FAU - Krukoff, T L
AU  - Krukoff TL
FAU - Turton, W E
AU  - Turton WE
FAU - Calaresu, F R
AU  - Calaresu FR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - EC 2.7.1.1 (Hexokinase)
SB  - IM
MH  - Animals
MH  - Brain/*enzymology
MH  - Diabetes Insipidus/*enzymology
MH  - Hexokinase/*metabolism
MH  - Histocytochemistry
MH  - Hypothalamo-Hypophyseal System/enzymology
MH  - Male
MH  - Pituitary Gland, Posterior/enzymology
MH  - Rats
MH  - Rats, Brattleboro
MH  - Rats, Inbred Strains
MH  - Tissue Distribution
MH  - Water Deprivation/*physiology
EDAT- 1986/08/01 00:00
MHDA- 1986/08/01 00:01
CRDT- 1986/08/01 00:00
PHST- 1986/08/01 00:00 [pubmed]
PHST- 1986/08/01 00:01 [medline]
PHST- 1986/08/01 00:00 [entrez]
AID - 10.1152/ajpregu.1986.251.2.R268 [doi]
PST - ppublish
SO  - Am J Physiol. 1986 Aug;251(2 Pt 2):R268-73. doi: 10.1152/ajpregu.1986.251.2.R268.