PMID- 3740309
OWN - NLM
STAT- MEDLINE
DCOM- 19860917
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 251
IP  - 2 Pt 2
DP  - 1986 Aug
TI  - Changes in forebrain hexokinase activity after aortic baroreceptor denervation.
PG  - R274-81
AB  - Although forebrain structures have been implicated in both the development and 
      maintenance of the elevated arterial pressure (AP) after aortic baroreceptor 
      denervation, little is known about the location of central structures involved in 
      the hypertensive process. In the present study, regions of the forebrain whose 
      metabolic activity was altered after aortic baroreceptor denervation were 
      functionally identified using hexokinase (HK) histochemistry in the rat. Three 
      days after bilateral aortic depressor nerve (ADN) transection AP was 
      significantly elevated compared with sham ADN-transected animals (143 +/- 1 and 
      122 +/- 2 mmHg, respectively). Significant increases in HK activity were observed 
      in the magno- and parvocellular components of the paraventricular nucleus of the 
      hypothalamus, supraoptic nucleus, nucleus circularis, median preoptic nucleus, 
      subfornical organ, and central nucleus of the amygdala in the ADN-transected 
      animals. These data have demonstrated that removal of aortic baroreceptor 
      afferent inputs alters the activity of forebrain structures previously implicated 
      in regulation of body fluid balance and AP and suggest that these structures are 
      involved in the hypertensive process after ADN transection.
FAU - Turton, W E
AU  - Turton WE
FAU - Ciriello, J
AU  - Ciriello J
FAU - Calaresu, F R
AU  - Calaresu FR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - EC 2.7.1.1 (Hexokinase)
SB  - IM
MH  - Animals
MH  - Aorta/*innervation
MH  - Blood Pressure
MH  - Brain/*enzymology
MH  - *Denervation
MH  - Heart Rate
MH  - Hexokinase/*metabolism
MH  - Histocytochemistry
MH  - Hypertension/enzymology
MH  - Male
MH  - Pressoreceptors/*physiology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Tissue Distribution
EDAT- 1986/08/01 00:00
MHDA- 1986/08/01 00:01
CRDT- 1986/08/01 00:00
PHST- 1986/08/01 00:00 [pubmed]
PHST- 1986/08/01 00:01 [medline]
PHST- 1986/08/01 00:00 [entrez]
AID - 10.1152/ajpregu.1986.251.2.R274 [doi]
PST - ppublish
SO  - Am J Physiol. 1986 Aug;251(2 Pt 2):R274-81. doi: 10.1152/ajpregu.1986.251.2.R274.