PMID- 37403376
OWN - NLM
STAT- MEDLINE
DCOM- 20230721
LR  - 20230721
IS  - 2049-632X (Electronic)
IS  - 2049-632X (Linking)
VI  - 81
DP  - 2023 Jan 17
TI  - Chlamydia pneumoniae-immunoglobulin E antibody responses in serum from children 
      with asthma.
LID - ftad015 [pii]
LID - 10.1093/femspd/ftad015 [doi]
AB  - Chlamydia pneumoniae is an obligate intracellular bacterium that causes 
      respiratory infections in humans. An association between persistent C. pneumoniae 
      infection and asthma pathogenesis has been described. It is unknown whether 
      specific immunoglobulin E (IgE) is a marker of persistent immune activation 
      responses. Therefore, the association between C. pneumoniae-specific-IgE 
      antibodies (Abs) and interferon (IFN)-gamma produced by C. pneumoniae-stimulated 
      peripheral blood mononuclear cells (PBMC) was examined. Blood was collected and 
      serum separated. PBMC from 63 children with or without stable asthma (N = 45 and 
      18, respectively) were infected or not infected with C. pneumoniae AR-39 and 
      cultured for up to 7 days. Supernatants were collected, and IFN-gamma levels 
      measured (ELISA). Serum C. pneumoniae-IgE Abs were detected by immunoblotting. C. 
      pneumoniae-IgE Abs were detected in asthmatics (27%), compared with 
      non-asthmatics (11%) (P = NS). IFN-gamma responses were more prevalent among 
      asthmatics who had positive C. pneumoniae-IgE Abs (60%) compared with asthmatics 
      without C. pneumoniae-IgE Abs (20%) (P = 0.1432). IFN-gamma responses in C. 
      pneumoniae-stimulated PBMC from children with asthma were more frequent in 
      children who had specific anti-C. pneumoniae-IgE Abs compared to those who did 
      not. This immune response may reflect persistent infection, which may contribute 
      to ongoing asthma symptoms.
CI  - (c) The Author(s) 2023. Published by Oxford University Press on behalf of FEMS.
FAU - Smith-Norowitz, Tamar A
AU  - Smith-Norowitz TA
AUID- ORCID: 0000-0002-8204-6728
AD  - State University of New York Downstate Health Sciences University, Brooklyn, NY 
      11203, USA.
FAU - Shulman, Anastasiya
AU  - Shulman A
AD  - State University of New York Downstate Health Sciences University, Brooklyn, NY 
      11203, USA.
FAU - Abdelmajid, Haram
AU  - Abdelmajid H
AD  - State University of New York Downstate Health Sciences University, Brooklyn, NY 
      11203, USA.
FAU - Hammerschlag, Margaret R
AU  - Hammerschlag MR
AD  - State University of New York Downstate Health Sciences University, Brooklyn, NY 
      11203, USA.
FAU - Joks, Rauno
AU  - Joks R
AD  - Department of Medicine, State University of New York Downstate Health Sciences 
      University, Brooklyn, NY 11203, USA.
FAU - Weaver, Diana
AU  - Weaver D
AD  - State University of New York Downstate Health Sciences University, Brooklyn, NY 
      11203, USA.
FAU - Kohlhoff, Stephan
AU  - Kohlhoff S
AD  - State University of New York Downstate Health Sciences University, Brooklyn, NY 
      11203, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pathog Dis
JT  - Pathogens and disease
JID - 101595366
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (Antibodies, Protozoan)
SB  - IM
MH  - Humans
MH  - Child
MH  - Immunoglobulin E
MH  - *Chlamydophila pneumoniae
MH  - Leukocytes, Mononuclear
MH  - Antibody Formation
MH  - Antibodies, Bacterial
MH  - Antibodies, Protozoan
MH  - *Asthma/complications
OTO - NOTNLM
OT  - Chlamydia pneumoniae
OT  - asthma
OT  - immunoglobulin E
OT  - interferon-gamma
EDAT- 2023/07/05 06:42
MHDA- 2023/07/21 06:44
CRDT- 2023/07/05 02:06
PHST- 2023/05/16 00:00 [received]
PHST- 2023/06/19 00:00 [revised]
PHST- 2023/07/03 00:00 [accepted]
PHST- 2023/07/21 06:44 [medline]
PHST- 2023/07/05 06:42 [pubmed]
PHST- 2023/07/05 02:06 [entrez]
AID - 7219311 [pii]
AID - 10.1093/femspd/ftad015 [doi]
PST - ppublish
SO  - Pathog Dis. 2023 Jan 17;81:ftad015. doi: 10.1093/femspd/ftad015.