PMID- 37403719
OWN - NLM
STAT- MEDLINE
DCOM- 20230822
LR  - 20230822
IS  - 1007-8738 (Print)
IS  - 1007-8738 (Linking)
VI  - 39
IP  - 7
DP  - 2023 Jul
TI  - [Resveratrol improves cognitive function in severely burned rats by inhibiting 
      hippocampal NF-kappaB/JNK pathway].
PG  - 604-609
AB  - Objective To investigate the protective effect of resveratrol (RSV) on improving 
      cognitive function in severely burned rats and its possible mechanism. Methods 18 
      male SD rats aged 18-20 months were randomly divided into 3 groups: control 
      group, model group and RSV group, with 6 rats in each group. After successful 
      modeling, the rats in RSV group were gavaged once daily with RSV (20 mg/kg). 
      Meanwhile, the rats in control group and model group were gavaged once daily with 
      an equal volume of sodium chloride solution. After 4 weeks, the cognitive 
      function of all rats was estimated by Step-down Test. The concentration of tumor 
      necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) protein in serum of rats were 
      detected by ELISA. The expression of IL-6, TNF-alpha mRNA and protein were estimated 
      by real-time PCR and Western blotting. The apoptosis of hippocampal neurons was 
      tested by terminal deoxynuclectidyl transferase-mediated dUTP-biotin nick end 
      labeling assay (TUNEL). The expression of nuclear transcription factor-kappaB 
      (NF-kappaB)/c-Jun N-terminal kinase (JNK) pathway-related proteins in hippocampus 
      were assessed by Western blotting. Results Compared with the rats in model group, 
      rats in RSV group exhibited improved cognitive function. Consistently, the rats 
      in RSV group had a reduced concentration of TNF-alpha and IL-6 in serum, decreased 
      mRNA and protein expressions of TNF-alpha and IL-6 in hippocampus, and decreased 
      apoptosis rate and relative expression of p-NF-kappaB p65/NF-kappaB p65 and p-JNK/JNK in 
      hippocampal neurons. Conclusion RSV alleviates inflammatory response and 
      hippocampal neuronal apoptosis by inhibiting NF-kappaB/JNK pathway, thereby improving 
      cognitive function in severely burned rats.
FAU - Xing, Liang
AU  - Xing L
AD  - Department of Burns and Plastic Surgery, The First Hospital of Hebei Medical 
      University, Shijiazhuang 050000, China.
FAU - Wei, Wei
AU  - Wei W
AD  - Department of Burns and Plastic Surgery, The First Hospital of Hebei Medical 
      University, Shijiazhuang 050000, China.
FAU - Zhang, Cuina
AU  - Zhang C
AD  - Department of Burns and Plastic Surgery, The First Hospital of Hebei Medical 
      University, Shijiazhuang 050000, China.
FAU - Gao, Bingquan
AU  - Gao B
AD  - Department of Burns and Plastic Surgery, The First Hospital of Hebei Medical 
      University, Shijiazhuang 050000, China.
FAU - Feng, Jianke
AU  - Feng J
AD  - Department of Burns and Plastic Surgery, The First Hospital of Hebei Medical 
      University, Shijiazhuang 050000, China. *Corresponding author, E-mail: 
      13931861003@126.com.
FAU - Ma, Leilei
AU  - Ma L
AD  - Department of Burns and Plastic Surgery, The First Hospital of Hebei Medical 
      University, Shijiazhuang 050000, China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
JT  - Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular 
      immunology
JID - 101139110
RN  - Q369O8926L (Resveratrol)
RN  - 0 (NF-kappa B)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Interleukin-6)
SB  - IM
MH  - *Resveratrol/pharmacology
MH  - Male
MH  - Animals
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Burns/drug therapy
MH  - *Cognition/drug effects
MH  - Hippocampus/metabolism
MH  - MAP Kinase Signaling System
MH  - NF-kappa B/metabolism
MH  - Tumor Necrosis Factor-alpha/blood
MH  - Interleukin-6/blood
MH  - Neurons/drug effects
MH  - Apoptosis
EDAT- 2023/07/05 06:42
MHDA- 2023/07/06 06:42
CRDT- 2023/07/05 05:28
PHST- 2023/07/06 06:42 [medline]
PHST- 2023/07/05 06:42 [pubmed]
PHST- 2023/07/05 05:28 [entrez]
PST - ppublish
SO  - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2023 Jul;39(7):604-609.