PMID- 37403903
OWN - NLM
STAT- MEDLINE
DCOM- 20230811
LR  - 20230814
IS  - 1097-0347 (Electronic)
IS  - 1043-3074 (Linking)
VI  - 45
IP  - 9
DP  - 2023 Sep
TI  - Nodal metastasis in surgically treated laryngeal squamous cell carcinoma.
PG  - 2303-2312
LID - 10.1002/hed.27437 [doi]
AB  - BACKGROUND: Management of the neck in laryngeal squamous cell carcinoma (LSCC) is 
      essential to oncologic control and survival. We aim to describe patterns and 
      rates of clinical/pathologic lymph node disease, elective neck dissection (END), 
      and occult lymph node metastasis (LNM) in patients with surgically-managed LSCC. 
      METHODS: Retrospective cohort study of patients in the National Cancer Database 
      (NCDB) diagnosed with LSCC between January 2004 and December 2016 who underwent 
      primary surgery. RESULTS: Seven thousand eight hundred and seventy-six patients 
      met inclusion criteria. For cN0 patients, the rates of END and occult LNM both 
      increased with tumor stage and were highest for supraglottic tumors. Predictors 
      of occult LNM included supraglottic site, pathologic T3 and T4 stage, positive 
      margins, and presence of lymphovascular invasion (p < 0.05). CONCLUSIONS: The 
      propensity for cervical LNM in surgically-managed LSCC varies based on primary 
      tumor site and stage, and a variety of disease factors increase risk of occult 
      LNM.
CI  - (c) 2023 Wiley Periodicals LLC.
FAU - Prasad, Aman
AU  - Prasad A
AUID- ORCID: 0000-0002-4961-2441
AD  - Perelman School of Medicine at the University of Pennsylvania, Philadelphia, 
      Pennsylvania, USA.
FAU - Carey, Ryan M
AU  - Carey RM
AUID- ORCID: 0000-0002-0186-2265
AD  - Department of Otolaryngology-Head & Neck Surgery, University of Miami Miller 
      School of Medicine, Miami, Florida, USA.
FAU - Panara, Kush
AU  - Panara K
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, University of 
      Pennsylvania, Philadelphia, Pennsylvania, USA.
FAU - Rajasekaran, Karthik
AU  - Rajasekaran K
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, University of 
      Pennsylvania, Philadelphia, Pennsylvania, USA.
FAU - Cannady, Steven B
AU  - Cannady SB
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, University of 
      Pennsylvania, Philadelphia, Pennsylvania, USA.
FAU - Newman, Jason G
AU  - Newman JG
AD  - Department of Otolaryngology-Head & Neck Surgery, Medical University of South 
      Carolina, Charleston, South Carolina, USA.
FAU - Brant, Jason A
AU  - Brant JA
AUID- ORCID: 0000-0002-3492-0679
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, University of 
      Pennsylvania, Philadelphia, Pennsylvania, USA.
FAU - Brody, Robert M
AU  - Brody RM
AUID- ORCID: 0000-0001-6639-8830
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, University of 
      Pennsylvania, Philadelphia, Pennsylvania, USA.
LA  - eng
PT  - Journal Article
DEP - 20230705
PL  - United States
TA  - Head Neck
JT  - Head & neck
JID - 8902541
SB  - IM
MH  - Humans
MH  - Squamous Cell Carcinoma of Head and Neck/pathology
MH  - Retrospective Studies
MH  - *Carcinoma, Squamous Cell/pathology
MH  - Neoplasm Staging
MH  - Neck Dissection
MH  - *Laryngeal Neoplasms/surgery/pathology
MH  - Lymphatic Metastasis
MH  - *Head and Neck Neoplasms/pathology
OTO - NOTNLM
OT  - head and neck
OT  - larynx cancer
OT  - metastasis
OT  - neck dissection
OT  - squamous cell carcinoma
EDAT- 2023/07/05 13:05
MHDA- 2023/08/11 06:42
CRDT- 2023/07/05 07:44
PHST- 2023/06/02 00:00 [revised]
PHST- 2023/01/18 00:00 [received]
PHST- 2023/06/09 00:00 [accepted]
PHST- 2023/08/11 06:42 [medline]
PHST- 2023/07/05 13:05 [pubmed]
PHST- 2023/07/05 07:44 [entrez]
AID - 10.1002/hed.27437 [doi]
PST - ppublish
SO  - Head Neck. 2023 Sep;45(9):2303-2312. doi: 10.1002/hed.27437. Epub 2023 Jul 5.