PMID- 37404690
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230718
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 15
DP  - 2023
TI  - Small extracellular vesicles: a novel drug delivery system for neurodegenerative 
      disorders.
PG  - 1184435
LID - 10.3389/fnagi.2023.1184435 [doi]
LID - 1184435
AB  - Neurodegenerative diseases (NDs) have a slow onset and are usually detected late 
      during disease. NDs are often difficult to cure due to the presence of the 
      blood-brain barrier (BBB), which makes it difficult to find effective treatments 
      and drugs, causing great stress and financial burden to families and society. 
      Currently, small extracellular vesicles (sEVs) are the most promising drug 
      delivery systems (DDSs) for targeted delivery of molecules to specific sites in 
      the brain as a therapeutic vehicle due to their low toxicity, low immunogenicity, 
      high stability, high delivery efficiency, high biocompatibility and trans-BBB 
      functionality. Here, we review the therapeutic application of sEVs in several 
      NDs, including Alzheimer's disease, Parkinson's disease, and Huntington's 
      disease, discuss the current barriers associated with sEVs and brain-targeted 
      DDS, and suggest future research directions.
CI  - Copyright (c) 2023 Pan, Chen, Hou, Hu and Jiao.
FAU - Pan, Renjie
AU  - Pan R
AD  - First Clinical Medical College, Gannan Medical University, Ganzhou, Jiangxi, 
      China.
AD  - Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, 
      Ganzhou, Jiangxi, China.
FAU - Chen, Dongdong
AU  - Chen D
AD  - First Clinical Medical College, Gannan Medical University, Ganzhou, Jiangxi, 
      China.
AD  - Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, 
      Ganzhou, Jiangxi, China.
FAU - Hou, Lanlan
AU  - Hou L
AD  - First Clinical Medical College, Gannan Medical University, Ganzhou, Jiangxi, 
      China.
AD  - Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, 
      Ganzhou, Jiangxi, China.
FAU - Hu, Rong
AU  - Hu R
AD  - Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, 
      Ganzhou, Jiangxi, China.
FAU - Jiao, Zhigang
AU  - Jiao Z
AD  - Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, 
      Ganzhou, Jiangxi, China.
AD  - Precision Medicine Center, First Affiliated Hospital of Gannan Medical 
      University, Ganzhou, Jiangxi, China.
AD  - Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular 
      Diseases, Ministry of Education, Gannan Medical University, Ganzhou, Jiangxi, 
      China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230619
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC10315580
OTO - NOTNLM
OT  - blood-brain barrier
OT  - brain targeting
OT  - drug delivery system
OT  - neurodegenerative diseases
OT  - small extracellular vesicles
OT  - treatment
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/07/05 13:05
MHDA- 2023/07/05 13:06
PMCR- 2023/01/01
CRDT- 2023/07/05 10:40
PHST- 2023/03/11 00:00 [received]
PHST- 2023/05/30 00:00 [accepted]
PHST- 2023/07/05 13:06 [medline]
PHST- 2023/07/05 13:05 [pubmed]
PHST- 2023/07/05 10:40 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2023.1184435 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2023 Jun 19;15:1184435. doi: 10.3389/fnagi.2023.1184435. 
      eCollection 2023.