PMID- 37404966
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230718
IS  - 1541-4094 (Print)
IS  - 1541-4108 (Electronic)
IS  - 1541-4094 (Linking)
VI  - 21
IP  - 3
DP  - 2023 Jul
TI  - A Review of MDMA-Assisted Therapy for Posttraumatic Stress Disorder.
PG  - 247-256
LID - 10.1176/appi.focus.20220088 [doi]
AB  - Posttraumatic stress disorder (PTSD) is a common chronic and disabling 
      psychiatric disorder that may develop after exposure to a traumatic life event. 
      There are existing evidence-based psychotherapies and pharmacotherapies for PTSD; 
      however, these treatments have significant limitations. 
      3,4-methylenedioxymethamphetamine (MDMA) was granted "breakthrough therapy" 
      status by the U.S. Food and Drug Administration (FDA) in 2017 for the treatment 
      of PTSD in conjunction with psychotherapy after preliminary Phase II results. 
      This treatment is currently being investigated in Phase III trials with 
      anticipated FDA approval of MDMA-assisted psychotherapy for PTSD in late 2023. 
      This article reviews the evidence base for MDMA-assisted psychotherapy for PTSD, 
      pharmacology and the proposed causal mechanisms of MDMA, risks and limitations of 
      the current evidence, and challenges and future directions for the field.
CI  - Copyright (c) 2023 by the American Psychiatric Association.
FAU - Lewis, Benjamin R
AU  - Lewis BR
AD  - Department of Psychiatry, University of Utah, Salt Lake City.
FAU - Byrne, Kevin
AU  - Byrne K
AD  - Department of Psychiatry, University of Utah, Salt Lake City.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230628
PL  - United States
TA  - Focus (Am Psychiatr Publ)
JT  - Focus (American Psychiatric Publishing)
JID - 101156081
PMC - PMC10316220
OTO - NOTNLM
OT  - Posttraumatic Stress Disorder
OT  - Psychotherapy
OT  - Trauma and stress-related disorder
COIS- The authors report no financial relationships with commercial interests.
EDAT- 2023/07/05 13:05
MHDA- 2023/07/05 13:06
PMCR- 2024/07/01
CRDT- 2023/07/05 10:45
PHST- 2024/07/01 00:00 [pmc-release]
PHST- 2023/07/05 13:06 [medline]
PHST- 2023/07/05 13:05 [pubmed]
PHST- 2023/07/05 10:45 [entrez]
AID - FOC_20220088 [pii]
AID - 10.1176/appi.focus.20220088 [doi]
PST - ppublish
SO  - Focus (Am Psychiatr Publ). 2023 Jul;21(3):247-256. doi: 
      10.1176/appi.focus.20220088. Epub 2023 Jun 28.