PMID- 37405609
OWN - NLM
STAT- MEDLINE
DCOM- 20230926
LR  - 20230926
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Linking)
VI  - 39
IP  - 9
DP  - 2023 Sep
TI  - Comprehensive echocardiographic assessment of right ventricular function, 
      pulmonary arterial elastic properties and ventricular-vascular coupling in adult 
      patients with repaired tetralogy of fallot: clinical significance of 3D derived 
      indices.
PG  - 1631-1641
LID - 10.1007/s10554-023-02857-3 [doi]
AB  - We aimed to comprehensively analyze by three-dimensional speckle-tracking 
      echocardiography (3DSTE) and Doppler echocardiography right ventricular (RV) 
      performance, pulmonary arterial (PA) elastic properties and right 
      ventricular-pulmonary artery coupling (RVPAC) in patients with repaired tetralogy 
      of Fallot (rTOF) and assess the feasibility and clinical utility of related 
      echocardiographic indices. Twenty-four adult patients with rTOF and twenty-four 
      controls were studied. RV end-diastolic volume(3D-RVEDV), RV end-systolic 
      volume(3D-RVESV), RV ejection fraction(3D-RVEF), RV longitudinal strain(3D-RVLS) 
      and RV area strain(3D-RVAS) were calculated by 3DSTE. RV end-systolic area 
      (RVESA) was obtained by planimetry. Pulmonary regurgitation (PR) was assessed as 
      trivial/mild or significant by cardiac magnetic resonance (CMR) and 
      color-Doppler. Pulmonary artery (PA) elastic properties were determined using 
      two-dimensional/Doppler echocardiography. RV systolic pressure (RVSP) was 
      measured using standard Doppler methods. RVPAC was assessed using various 
      3DSTE-derived parameters (3DRVAS/RVSP, 3DRVLS/RVESA, 3DRVAS/RVESV). Overall, 
      3DRVEF and 3DRVAS were impaired in rTOF patients compared with controls. PA 
      pulsatility and capacitance were reduced (p = 0.003) and PA elastance was higher 
      (p = 0.0007) compared to controls. PA elastance had a positive correlation with 
      3DRVEDV (r = 0.64, p = 0.002) and 3DRVAS (r = 0.51, p = 0.02). By ROC (receiver 
      operating characteristics) analysis, 3DRVAS/RVESV, 3DRVAS/RVSP and 3DRVLS/RVESA 
      cutoff values of 0.31%/mmHg, 0.57%/mmHg and 0.86%/mmHg, respectively, had 91%, 
      88% and 88% sensitivity and 81%, 81% and 79% specificity in identifying exercise 
      capacity impairment. In rTOF patients increased 3DSTE-derived RV volumes and 
      impaired RV ejection fraction and strain are associated with reduced PA 
      pulsatility and capacitance and increased PA elastance. 3DSTE-derived RVPAC 
      parameters using different afterload-markers are accurate indices of exercise 
      capacity.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Nature B.V.
FAU - Vitarelli, Antonio
AU  - Vitarelli A
AD  - Depts of Cardiology, Cardiac Surgery and Radiology, Sapienza University, Rome, 
      Italy. vitar@tiscali.it.
AD  - Cardiodiagnostica, via Lima 35, Rome, 00198, Italy. vitar@tiscali.it.
FAU - Miraldi, Fabio
AU  - Miraldi F
AD  - Depts of Cardiology, Cardiac Surgery and Radiology, Sapienza University, Rome, 
      Italy.
FAU - Capotosto, Lidia
AU  - Capotosto L
AD  - Depts of Cardiology, Cardiac Surgery and Radiology, Sapienza University, Rome, 
      Italy.
AD  - Cardiodiagnostica, via Lima 35, Rome, 00198, Italy.
FAU - Galea, Nicola
AU  - Galea N
AD  - Depts of Cardiology, Cardiac Surgery and Radiology, Sapienza University, Rome, 
      Italy.
FAU - Francone, Marco
AU  - Francone M
AD  - Depts of Cardiology, Cardiac Surgery and Radiology, Sapienza University, Rome, 
      Italy.
FAU - Marchitelli, Livia
AU  - Marchitelli L
AD  - Depts of Cardiology, Cardiac Surgery and Radiology, Sapienza University, Rome, 
      Italy.
FAU - Viceconte, Nicola
AU  - Viceconte N
AD  - Depts of Cardiology, Cardiac Surgery and Radiology, Sapienza University, Rome, 
      Italy.
FAU - Smaldone, Costantino
AU  - Smaldone C
AD  - San Carlo Hospital, Potenza, Italy.
FAU - Mangieri, Enrico
AU  - Mangieri E
AD  - Depts of Cardiology, Cardiac Surgery and Radiology, Sapienza University, Rome, 
      Italy.
FAU - Nguyen, Bich Lien
AU  - Nguyen BL
AD  - Depts of Cardiology, Cardiac Surgery and Radiology, Sapienza University, Rome, 
      Italy.
FAU - Tanzilli, Gaetano
AU  - Tanzilli G
AD  - Depts of Cardiology, Cardiac Surgery and Radiology, Sapienza University, Rome, 
      Italy.
FAU - Mancone, Massimo
AU  - Mancone M
AD  - Depts of Cardiology, Cardiac Surgery and Radiology, Sapienza University, Rome, 
      Italy.
FAU - Al-Kindy, Sulaiman
AU  - Al-Kindy S
AD  - Depts of Cardiology, Cardiac Surgery and Radiology, Sapienza University, Rome, 
      Italy.
LA  - eng
PT  - Journal Article
DEP - 20230705
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
SB  - IM
MH  - Humans
MH  - Adult
MH  - *Tetralogy of Fallot/diagnostic imaging/surgery
MH  - Pulmonary Artery/diagnostic imaging
MH  - Ventricular Function, Right
MH  - *Hypertension, Pulmonary
MH  - Clinical Relevance
MH  - Predictive Value of Tests
MH  - Echocardiography/methods
MH  - *Ventricular Dysfunction, Right/diagnostic imaging/etiology
OTO - NOTNLM
OT  - Pulmonary artery elastance
OT  - Repaired tetralogy of Fallot
OT  - Right ventricular function
OT  - Right ventricular-pulmonary artery coupling
OT  - Three-dimensional speckle tracking echocardiography
EDAT- 2023/07/05 13:05
MHDA- 2023/09/26 13:43
CRDT- 2023/07/05 11:13
PHST- 2023/02/06 00:00 [received]
PHST- 2023/04/21 00:00 [accepted]
PHST- 2023/09/26 13:43 [medline]
PHST- 2023/07/05 13:05 [pubmed]
PHST- 2023/07/05 11:13 [entrez]
AID - 10.1007/s10554-023-02857-3 [pii]
AID - 10.1007/s10554-023-02857-3 [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2023 Sep;39(9):1631-1641. doi: 
      10.1007/s10554-023-02857-3. Epub 2023 Jul 5.