PMID- 37405780
OWN - NLM
STAT- MEDLINE
DCOM- 20230920
LR  - 20231102
IS  - 1557-8682 (Electronic)
IS  - 1527-0297 (Linking)
VI  - 24
IP  - 3
DP  - 2023 Sep
TI  - Hyperhomocysteinemia, High Altitude, and Varied Retinal Manifestations: 
      Unravelling the Enigma.
PG  - 234-237
LID - 10.1089/ham.2023.0028 [doi]
AB  - Rana, Vipin, Meenu Dangi, Sandepan Bandopadhayay, Vijay K. Sharma, Satyabrat 
      Srikumar, Jitesh Goyal, and B.V. Rao. Hyperhomocysteinemia, High Altitude, and 
      Varied Retinal Manifestations: Unravelling the Enigma. High Alt Med Biol. 
      24:234-237, 2023.-We present five cases of young defense personnel, who were 
      posted at high altitude (HA) for >6 months and presented with reduction of vision 
      between June 2022 and February 2023. The diagnosis made were ocular ischemic 
      syndrome, central retinal artery occlusion, central retinal vein occlusion, 
      branch retinal vein occlusion, and branch retinal artery occlusion. There were no 
      associated comorbidities. Hematological workup revealed increased serum 
      homocysteine and hemoglobin in all patients. Computed tomography angiography was 
      done in cases of ocular ischemic syndrome, and central retinal artery occlusion, 
      which revealed occlusion of carotid artery. All patients were given tab folic 
      acid in view of hyperhomocysteinemia (HHcy). This case series highlights that 
      prolonged exposure to HA may lead to HHcy, which can directly or indirectly lead 
      to various sight-threatening retinal diseases. Thus, effective preventive 
      strategies, such as dietary or pharmacological interventions aimed at lowering 
      serum homocysteine levels, are crucial for individuals posted at HA for longer 
      duration.
FAU - Rana, Vipin
AU  - Rana V
AUID- ORCID: 0000-0002-1382-256X
AD  - Command Hospital Eastern Command, Kolkata, India.
FAU - Dangi, Meenu
AU  - Dangi M
AD  - Command Hospital Western Command, Haryana, India.
FAU - Bandopadhayay, Sandepan
AU  - Bandopadhayay S
AD  - Command Hospital Eastern Command, Kolkata, India.
FAU - Sharma, Vijay K
AU  - Sharma VK
AD  - Command Hospital Eastern Command, Kolkata, India.
FAU - Srikumar, Satyabrat
AU  - Srikumar S
AD  - Command Hospital Eastern Command, Kolkata, India.
FAU - Goyal, Jitesh
AU  - Goyal J
AD  - Command Hospital Eastern Command, Kolkata, India.
FAU - Rao, B V
AU  - Rao BV
AD  - Command Hospital Eastern Command, Kolkata, India.
LA  - eng
PT  - Journal Article
DEP - 20230703
PL  - United States
TA  - High Alt Med Biol
JT  - High altitude medicine & biology
JID - 100901183
RN  - 935E97BOY8 (Folic Acid)
SB  - IM
MH  - Humans
MH  - *Hyperhomocysteinemia/complications
MH  - Altitude
MH  - *Retinal Vein Occlusion/diagnosis
MH  - *Retinal Artery Occlusion/diagnosis/etiology
MH  - Folic Acid
OTO - NOTNLM
OT  - folate
OT  - high altitude
OT  - hyperhomocysteinemia
OT  - retinal diseases
EDAT- 2023/07/05 13:05
MHDA- 2023/09/20 06:42
CRDT- 2023/07/05 11:35
PHST- 2023/09/20 06:42 [medline]
PHST- 2023/07/05 13:05 [pubmed]
PHST- 2023/07/05 11:35 [entrez]
AID - 10.1089/ham.2023.0028 [doi]
PST - ppublish
SO  - High Alt Med Biol. 2023 Sep;24(3):234-237. doi: 10.1089/ham.2023.0028. Epub 2023 
      Jul 3.