PMID- 37406418 OWN - NLM STAT- MEDLINE DCOM- 20230927 LR - 20230927 IS - 1878-0334 (Electronic) IS - 1871-4021 (Linking) VI - 17 IP - 8 DP - 2023 Aug TI - Exploration for the reference interval of C-reactive protein in the Chinese longevity people over 90 years of age. PG - 102817 LID - S1871-4021(23)00113-3 [pii] LID - 10.1016/j.dsx.2023.102817 [doi] AB - BACKGROUND: Older individuals tend to develop chronic inflammation. As a commonly used nonspecific inflammatory marker, C-reactive protein (CRP) can predict metabolic syndrome, cardiovascular diseases, etc. However, little is known about CRP levels in longevity people. OBJECTIVES: Investigate the distribution and correlates of CRP and provide a reference for the establishment of normal interval values in Chinese longevity people over 90 years of age. METHODS: We performed a correlation analysis to evaluate the correlation between CRP levels and longevity based on the basic demographic characteristics, anthropometric measurements and blood data of 4,418 participants in the 2015 China Health and Retirement Longitudinal Study and 636 participants in an ongoing longitudinal study of natural longevity people in Guangxi. On this basis, the CRP reference interval for longevity was explored. RESULTS: The CRP concentration was significantly different among the three age groups, with a median of 3.80 mg/L for those older than 90 years, which was significantly higher than that for those aged 45-64 years (median 1.20 mg/L, p < 0.001) and 65-89 years (median 1.30 mg/L, p < 0.001). Body mass index, waist circumference, the waist-to-height ratio, systolic blood pressure, diastolic blood pressure, and fasting and postprandial blood glucose, triglyceride, total cholesterol and low-density lipoprotein cholesterol levels were positively correlated with CRP levels, while fasting high-density lipoprotein cholesterol was negatively correlated with CRP levels. The CRP reference interval (RI) value in longevity people was 0.25-9.22 mg/L. CONCLUSION: The concentrations of CRP increased with advancing age, and the CRP reference interval was different between older and younger adults. CI - Copyright (c) 2023 Research Trust of DiabetesIndia (DiabetesIndia) and National Diabetes Obesity and Cholesterol Foundation (N-DOC). Published by Elsevier Ltd. All rights reserved. FAU - Gao, Danni AU - Gao D AD - The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing, 100730, PR China; Peking University Fifth School of Clinical Medicine (Beijing Hospital), Beijing, 100730, PR China. FAU - Ni, Xiaolin AU - Ni X AD - The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing, 100730, PR China. FAU - Fang, Sihang AU - Fang S AD - The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing, 100730, PR China. FAU - Wang, Zhaoping AU - Wang Z AD - The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing, 100730, PR China. FAU - Jiao, Juan AU - Jiao J AD - Clinical Laboratory Department, The Seventh Medical Center, PLA General Hospital, Beijing, 100730, PR China. FAU - Liu, Dizhi AU - Liu D AD - The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing, 100730, PR China. FAU - Huang, Xiuqing AU - Huang X AD - The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing, 100730, PR China. FAU - Jiang, Mingjun AU - Jiang M AD - Respiratory Department, Beijing Children's Hospital, Capital Medical University, China National Clinical Research Center of Respiratory Diseases, National Center for Children's Health, Beijing, 100045, PR China. FAU - Zhou, Qi AU - Zhou Q AD - The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing, 100730, PR China. FAU - Sun, Liang AU - Sun L AD - The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing, 100730, PR China. FAU - Zhu, Xiaoquan AU - Zhu X AD - The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing, 100730, PR China. FAU - Su, Huabin AU - Su H AD - Jiangbin Hospital, Guangxi Zhuang Autonomous Region, 530021, PR China. FAU - Li, Rongqiao AU - Li R AD - Jiangbin Hospital, Guangxi Zhuang Autonomous Region, 530021, PR China. FAU - Huang, Bin AU - Huang B AD - Jiangbin Hospital, Guangxi Zhuang Autonomous Region, 530021, PR China. FAU - Lv, Yuan AU - Lv Y AD - Jiangbin Hospital, Guangxi Zhuang Autonomous Region, 530021, PR China. FAU - Pang, Guofang AU - Pang G AD - Jiangbin Hospital, Guangxi Zhuang Autonomous Region, 530021, PR China. FAU - Hu, Caiyou AU - Hu C AD - Jiangbin Hospital, Guangxi Zhuang Autonomous Region, 530021, PR China. FAU - Yang, Ze AU - Yang Z AD - The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing, 100730, PR China. FAU - Yuan, Huiping AU - Yuan H AD - The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing, 100730, PR China; Peking University Fifth School of Clinical Medicine (Beijing Hospital), Beijing, 100730, PR China. Electronic address: yuanhuiping@126.com. LA - eng PT - Journal Article DEP - 20230630 PL - Netherlands TA - Diabetes Metab Syndr JT - Diabetes & metabolic syndrome JID - 101462250 RN - 9007-41-4 (C-Reactive Protein) RN - 0 (Cholesterol, HDL) SB - IM MH - Aged, 80 and over MH - Humans MH - Body Mass Index MH - *C-Reactive Protein/analysis/metabolism MH - China/epidemiology MH - Cholesterol, HDL MH - *East Asian People MH - Longitudinal Studies MH - Risk Factors MH - Middle Aged MH - Aged MH - Age Factors OTO - NOTNLM OT - C-reactive protein (CRP) OT - Longevity OT - Reference interval OT - Systemic inflammation COIS- Declaration of competing interest The authors report no conflicts of interest in this work. EDAT- 2023/07/06 01:08 MHDA- 2023/09/13 06:42 CRDT- 2023/07/05 18:02 PHST- 2023/03/05 00:00 [received] PHST- 2023/06/21 00:00 [revised] PHST- 2023/06/23 00:00 [accepted] PHST- 2023/09/13 06:42 [medline] PHST- 2023/07/06 01:08 [pubmed] PHST- 2023/07/05 18:02 [entrez] AID - S1871-4021(23)00113-3 [pii] AID - 10.1016/j.dsx.2023.102817 [doi] PST - ppublish SO - Diabetes Metab Syndr. 2023 Aug;17(8):102817. doi: 10.1016/j.dsx.2023.102817. Epub 2023 Jun 30.