PMID- 37407236 OWN - NLM STAT- MEDLINE DCOM- 20230707 LR - 20230718 IS - 1757-790X (Electronic) IS - 1757-790X (Linking) VI - 16 IP - 7 DP - 2023 Jul 5 TI - Unusual lipid poor spindle cell lipoma. LID - 10.1136/bcr-2022-254522 [doi] LID - e254522 AB - Spindle cell lipomas (SCLs) containing minimal fat are rare and can be diagnostically challenging due to their similar radiographic appearance to other benign and malignant tumours. SCLs are benign lipomatous tumours that typically occur in middle aged to elderly men as slow-growing, painless masses in the subcutaneous tissue of the posterior neck, shoulders or back. However, rarely these tumours can arise in unusual locations such as the lower extremities. We present an unusual case of a lipid poor SCL occurring in the lower extremity. Initial clinical and radiographic findings were suspicious for a malignancy. Two core biopsies demonstrated benign fibro collagenous tissue, so a marginal excision was performed. Final histopathological and immunohistochemical stains confirmed the diagnosis of an SCL. Radiologists, pathologists and oncologic surgeons should be aware of this lipomatous tumour's potential to present in unusual locations with minimal fatty components to increase confidence in radiologic-pathological concordance. CI - (c) BMJ Publishing Group Limited 2023. No commercial re-use. See rights and permissions. Published by BMJ. FAU - Schwartz, Benjamin R AU - Schwartz BR AUID- ORCID: 0000-0002-8121-8911 AD - Diagnostic Radiology, University of Miami Miller School of Medicine, Miami, Florida, USA benjamin.schwartz@jhsmiami.org. FAU - Subhawong, Ty AU - Subhawong T AD - Diagnostic Radiology, University of Miami Miller School of Medicine, Miami, Florida, USA. FAU - Subhawong, Andrea Proctor AU - Subhawong AP AD - Orthopedic Oncology, Baptist Health South Florida Inc, Plantation, Florida, USA. FAU - de Souza, Felipe Ferreira AU - de Souza FF AD - Diagnostic Radiology, University of Miami Miller School of Medicine, Miami, Florida, USA. FAU - Pretell-Mazzini, Juan AU - Pretell-Mazzini J AD - Orthopedic Oncology, Baptist Health South Florida Inc, Plantation, Florida, USA. LA - eng PT - Case Reports PT - Journal Article DEP - 20230705 PL - England TA - BMJ Case Rep JT - BMJ case reports JID - 101526291 RN - 0 (Antigens, CD34) RN - 0 (Lipids) SB - IM MH - Male MH - Aged MH - Middle Aged MH - Humans MH - *Lipoma/diagnostic imaging/surgery MH - Torso/pathology MH - Lower Extremity/pathology MH - Antigens, CD34 MH - Lipids PMC - PMC10335508 OTO - NOTNLM OT - Orthopaedics OT - Pathology OT - Radiology OT - Surgical oncology COIS- Competing interests: None declared. EDAT- 2023/07/06 01:08 MHDA- 2023/07/07 06:42 PMCR- 2025/07/05 CRDT- 2023/07/05 21:13 PHST- 2025/07/05 00:00 [pmc-release] PHST- 2023/07/07 06:42 [medline] PHST- 2023/07/06 01:08 [pubmed] PHST- 2023/07/05 21:13 [entrez] AID - 16/7/e254522 [pii] AID - bcr-2022-254522 [pii] AID - 10.1136/bcr-2022-254522 [doi] PST - epublish SO - BMJ Case Rep. 2023 Jul 5;16(7):e254522. doi: 10.1136/bcr-2022-254522.