PMID- 37407529
OWN - NLM
STAT- MEDLINE
DCOM- 20230710
LR  - 20230718
IS  - 1000-503X (Print)
IS  - 1000-503X (Linking)
VI  - 45
IP  - 3
DP  - 2023 Jun
TI  - [Pathological Types,Expression of Mismatch Repair Protein,Human Epidermal Growth 
      Factor Receptor 2,and Pan-TRK,and Eostein-Barr Virus Infection in Patients With 
      Colorectal Cancer Resected in Tibet].
PG  - 422-428
LID - 10.3881/j.issn.1000-503X.15343 [doi]
AB  - Objective To study the pathological types,expression of mismatch repair 
      protein,human epidermal growth factor receptor 2(HER2),and Pan-TRK,and 
      Epstein-Barr virus(EBV)infection in patients with colorectal cancer resected in 
      Tibet. Methods A total of 79 patients with colorectal cancer resected in Tibet 
      Autonomous Region People's Hospital from December 2013 to July 2021 were enrolled 
      in this study.The clinical and pathological data of the patients were 
      collected.The expression of mismatch repair protein,HER2,and Pan-TRK was detected 
      by immunohistochemical(IHC)staining,and detection of HER2 gene by fluorescence in 
      situ hybridization(FISH)in the patients with HER2 IHC results of 2+ or above.EBV 
      was detected by in situ hybridization with EBV-encoded small RNA. Results A total 
      of 79 colorectal cancer patients were included in this study,with the 
      male-to-female ratio of 1.26:1 and the mean age of(57.06+/-12.74)years(24-83 
      years).Among them,4 patients received preoperative neoadjuvant therapy.Colonic 
      cancer and rectal cancer occurred in 57(57/79,72.15%,including 31 and 26 in the 
      right colon and left colon,respectively)and 
      22(22/79,27.85%)patients,respectively.The maximum diameter of tumor varied within 
      the range of 1-20 cm,with the mean of(6.61+/-3.33)cm.Among the 79 colorectal cancer 
      patients,75(75/79,94.94%)patients showed adenocarcinoma.Lymph node metastasis 
      occurred in 12(12/21,57.14%)out of the 21 patients with severe tumor 
      budding,13(13/23,56.52%)out of the 23 patients with moderate tumor budding,and 
      2(2/31,6.45%)out of the 31 patients with mild tumor budding,respectively.The 
      lymph node metastasis rate showed differences between the patients with 
      severe/moderate tumor budding and the patients with mild tumor budding(all 
      P<0.001).The IHC staining showed that mismatch repair protein was negative in 
      10(10/65,15.38%)patients,including 5 patients with both MSH2 and MSH6 negative,4 
      patients with both MLH1 and PMS2 negative,and 1 patient with MSH6 
      negative.Pan-TRK was negative in 65 patients.The IHC results of HER2 showed 0 or 
      1+ in 60 patients and 2+ in 5 patients.FISH showed no positive signal in the 5 
      patients with HER2 IHC results of 2+.The detection with EBV-encoded small RNA 
      showed positive result in 1(1/65,1.54%)patient. Conclusions Non-specific 
      adenocarcinoma of the right colon is the most common in the patients with 
      colorectal cancer resected in Tibet,and 15% of the patients showed mismatch 
      repair protein defects.EBV-associated colorectal carcer is rare,Pan-TRK 
      expression and HER2 gene amplification are seldom.The colorectal cancer patients 
      with moderate and severe tumor budding are more likely to have lymph node 
      metastasis.
FAU - Luo, Han-Huan
AU  - Luo HH
AD  - Department of Pathology,Tibet Autonomous Region People's Hospital,Lhasa 
      850000,China.
FAU - Huo, Zhen
AU  - Huo Z
AD  - Department of Pathology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
FAU - BIANbazhaxi
AU  - BIANbazhaxi
AD  - Department of General Surgery,Tibet Autonomous Region People's Hospital,Lhasa 
      850000,China.
FAU - Wang, Qian
AU  - Wang Q
AD  - Department of Pathology,Tibet Autonomous Region People's Hospital,Lhasa 
      850000,China.
FAU - DUObula
AU  - DUObula
AD  - Department of Pathology,Tibet Autonomous Region People's Hospital,Lhasa 
      850000,China.
FAU - NImazhuoma
AU  - NImazhuoma
AD  - Department of Pathology,Tibet Autonomous Region People's Hospital,Lhasa 
      850000,China.
FAU - DA, Zhen
AU  - DA Z
AD  - Department of Pathology,Tibet Autonomous Region People's Hospital,Lhasa 
      850000,China.
FAU - Guo, Ping-Ping
AU  - Guo PP
AD  - Department of Pathology,Tibet Autonomous Region People's Hospital,Lhasa 
      850000,China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Yi Xue Ke Xue Yuan Xue Bao
JT  - Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
JID - 8006230
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (DNA-Binding Proteins)
RN  - EC 2.7.10.1 (ERBB2 protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Adenocarcinoma
MH  - Biomarkers, Tumor/genetics
MH  - *Colorectal Neoplasms/pathology
MH  - DNA Mismatch Repair
MH  - DNA-Binding Proteins/genetics
MH  - *Epstein-Barr Virus Infections/diagnosis
MH  - Herpesvirus 4, Human/genetics/metabolism
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphatic Metastasis
MH  - Tibet
MH  - Young Adult
MH  - Aged, 80 and over
OTO - NOTNLM
OT  - Epstein-Barr virus
OT  - Pan-TRK
OT  - Tibet
OT  - colorectal cancer
OT  - human epidermal growth factor receptor 2
OT  - mismatch repair protein
OT  - pathological type
EDAT- 2023/07/06 01:08
MHDA- 2023/07/07 06:42
CRDT- 2023/07/05 23:03
PHST- 2023/07/07 06:42 [medline]
PHST- 2023/07/06 01:08 [pubmed]
PHST- 2023/07/05 23:03 [entrez]
AID - 1688555448061-22703299 [pii]
AID - 10.3881/j.issn.1000-503X.15343 [doi]
PST - ppublish
SO  - Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2023 Jun;45(3):422-428. doi: 
      10.3881/j.issn.1000-503X.15343.