PMID- 37408066
OWN - NLM
STAT- MEDLINE
DCOM- 20230707
LR  - 20230718
IS  - 1743-422X (Electronic)
IS  - 1743-422X (Linking)
VI  - 20
IP  - 1
DP  - 2023 Jul 5
TI  - Glycyrrhiza polysaccharides inhibits PRRSV replication.
PG  - 140
LID - 10.1186/s12985-023-02052-9 [doi]
LID - 140
AB  - Glycyrrhiza polysaccharide (GCP) is a natural plant active polysaccharide 
      extracted from traditional Chinese medicine licorice. In this research, we 
      studied the antiviral activity of glycyrrhiza polysaccharide against porcine 
      reproductive and respiratory syndrome virus (PRRSV), a virus of the Arteriviridae 
      family, with a high rate of variation and has caused huge economic losses to the 
      pig industry in various countries since its discovery. Our results show that GCP 
      can inhibit PRRSV replication in a dose-dependent manner. Furthermore, GCP could 
      inhibit the mRNA expression of receptor genes CD163 and NF-kappaB p65 and promote the 
      mRNA expression of the SLA-7 gene. Because of these results, GCP can be used as a 
      candidate drug to prevent and treat PRRS.
CI  - (c) 2023. The Author(s).
FAU - Yang, Youbing
AU  - Yang Y
AD  - College of Animal Science and Technology, Henan University of Science and 
      Technology, Luoyang, 471023, China.
AD  - Luoyang Key Laboratory of Animal Genetics and Breeding, Luoyang, 471023, China.
FAU - Liu, Yongjian
AU  - Liu Y
AD  - College of Animal Science and Technology, Henan University of Science and 
      Technology, Luoyang, 471023, China.
AD  - Luoyang Key Laboratory of Animal Genetics and Breeding, Luoyang, 471023, China.
FAU - Lou, Ran
AU  - Lou R
AD  - College of Animal Science and Technology, Henan University of Science and 
      Technology, Luoyang, 471023, China.
AD  - Luoyang Key Laboratory of Animal Genetics and Breeding, Luoyang, 471023, China.
FAU - Lei, Ying
AU  - Lei Y
AD  - College of Animal Science and Technology, Henan University of Science and 
      Technology, Luoyang, 471023, China.
AD  - Luoyang Key Laboratory of Animal Genetics and Breeding, Luoyang, 471023, China.
FAU - Li, Gan
AU  - Li G
AD  - College of Animal Science and Technology, Henan University of Science and 
      Technology, Luoyang, 471023, China.
AD  - Luoyang Key Laboratory of Animal Genetics and Breeding, Luoyang, 471023, China.
FAU - Xu, Zhiqian
AU  - Xu Z
AD  - College of Animal Science and Technology, Henan University of Science and 
      Technology, Luoyang, 471023, China.
AD  - Luoyang Key Laboratory of Animal Genetics and Breeding, Luoyang, 471023, China.
FAU - You, Xiangbin
AU  - You X
AD  - College of Animal Science and Technology, Henan University of Science and 
      Technology, Luoyang, 471023, China. yxb0710@163.com.
AD  - Luoyang Key Laboratory of Animal Genetics and Breeding, Luoyang, 471023, China. 
      yxb0710@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230705
PL  - England
TA  - Virol J
JT  - Virology journal
JID - 101231645
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Swine
MH  - Animals
MH  - *Porcine respiratory and reproductive syndrome virus
MH  - *Porcine Reproductive and Respiratory Syndrome
MH  - Cell Line
MH  - *Glycyrrhiza
MH  - RNA, Messenger
MH  - Virus Replication
PMC - PMC10320881
OTO - NOTNLM
OT  - CD163
OT  - Glycyrrhiza polysaccharide
OT  - NF-kappaB
OT  - PRRSV
OT  - SLA-7
COIS- The authors declare that there is no conflict of interest.
EDAT- 2023/07/06 01:08
MHDA- 2023/07/07 06:42
PMCR- 2023/07/05
CRDT- 2023/07/05 23:48
PHST- 2023/01/12 00:00 [received]
PHST- 2023/04/25 00:00 [accepted]
PHST- 2023/07/07 06:42 [medline]
PHST- 2023/07/06 01:08 [pubmed]
PHST- 2023/07/05 23:48 [entrez]
PHST- 2023/07/05 00:00 [pmc-release]
AID - 10.1186/s12985-023-02052-9 [pii]
AID - 2052 [pii]
AID - 10.1186/s12985-023-02052-9 [doi]
PST - epublish
SO  - Virol J. 2023 Jul 5;20(1):140. doi: 10.1186/s12985-023-02052-9.