PMID- 37409479
OWN - NLM
STAT- MEDLINE
DCOM- 20230831
LR  - 20230831
IS  - 1470-8752 (Electronic)
IS  - 0300-5127 (Linking)
VI  - 51
IP  - 4
DP  - 2023 Aug 31
TI  - Regulation of electron transfer in the terminal step of the respiratory chain.
PG  - 1611-1619
LID - 10.1042/BST20221449 [doi]
AB  - In mitochondria, electrons are transferred along a series of enzymes and electron 
      carriers that are referred to as the respiratory chain, leading to the synthesis 
      of cellular ATP. The series of the interprotein electron transfer (ET) reactions 
      is terminated by the reduction in molecular oxygen at Complex IV, cytochrome c 
      oxidase (CcO) that is coupled with the proton pumping from the matrix to the 
      inner membrane space. Unlike the ET reactions from Complex I to Complex III, the 
      ET reaction to CcO, mediated by cytochrome c (Cyt c), is quite specific in that 
      it is irreversible with suppressed electron leakage, which characterizes the ET 
      reactions in the respiratory chain and is thought to play a key role in the 
      regulation of mitochondrial respiration. In this review, we summarize the recent 
      findings regarding the molecular mechanism of the ET reaction from Cyt c to CcO 
      in terms of specific interaction between two proteins, a molecular breakwater, 
      and the effects of the conformational fluctuation on the ET reaction, 
      conformational gating. Both of these are essential factors, not only in the ET 
      reaction from Cyt c to CcO, but also in the interprotein ET reactions in general. 
      We also discuss the significance of a supercomplex in the terminal ET reaction, 
      which provides information on the regulatory factors of the ET reactions that are 
      specific to the mitochondrial respiratory chain.
CI  - (c) 2023 The Author(s). Published by Portland Press Limited on behalf of the 
      Biochemical Society.
FAU - Sato, Wataru
AU  - Sato W
AD  - Department of Life Science, Graduate School of Life Science, University of Hyogo, 
      Ako, Hyogo 678-1297, Japan.
FAU - Ishimori, Koichiro
AU  - Ishimori K
AUID- ORCID: 0000-0002-5868-0462
AD  - Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 
      060-0810, Japan.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Biochem Soc Trans
JT  - Biochemical Society transactions
JID - 7506897
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
RN  - 9007-43-6 (Cytochromes c)
SB  - IM
MH  - Electron Transport
MH  - *Electrons
MH  - *Electron Transport Complex IV/metabolism
MH  - Mitochondrial Membranes/metabolism
MH  - Mitochondria/metabolism
MH  - Cytochromes c/metabolism
MH  - Oxidation-Reduction
OTO - NOTNLM
OT  - breakwater
OT  - complex IV
OT  - conformational gating
OT  - cytochrome c
OT  - electron transfer
OT  - supercomplex
EDAT- 2023/07/06 06:42
MHDA- 2023/08/31 06:41
CRDT- 2023/07/06 05:33
PHST- 2023/04/27 00:00 [received]
PHST- 2023/06/23 00:00 [revised]
PHST- 2023/06/26 00:00 [accepted]
PHST- 2023/08/31 06:41 [medline]
PHST- 2023/07/06 06:42 [pubmed]
PHST- 2023/07/06 05:33 [entrez]
AID - 233260 [pii]
AID - 10.1042/BST20221449 [doi]
PST - ppublish
SO  - Biochem Soc Trans. 2023 Aug 31;51(4):1611-1619. doi: 10.1042/BST20221449.