PMID- 37410937
OWN - NLM
STAT- MEDLINE
DCOM- 20230814
LR  - 20230814
IS  - 1944-0057 (Electronic)
IS  - 1944-0057 (Linking)
VI  - 40
IP  - 8
DP  - 2023 Aug
TI  - Simultaneous determination of cyanide and thiocyanate in milk by GC-MS/MS using 
      cetyltrimethylammonium bromide as both phase transfer catalyst and protein 
      precipitant.
PG  - 1025-1034
LID - 10.1080/19440049.2023.2227742 [doi]
AB  - A method was developed for simultaneous determination of cyanide and thiocyanate 
      in milk by gas chromatography-tandem quadrupole mass spectrometry (GC-MS/MS). 
      Cyanide and thiocyanate were derivatized with pentafluorobenzyl bromide (PFBBr) 
      as PFB-CN and PFB-SCN, respectively. Cetyltrimethylammonium bromide (CTAB) was 
      employed both as a phase transfer catalyst and a protein precipitant in the 
      sample pretreatment, which facilitates the separation of the organic and aqueous 
      phases, and greatly simplifies the pretreatment procedures to achieve 
      simultaneous and rapid determination of cyanide and thiocyanate. Under the 
      optimized conditions, the limits of detection (LODs) of cyanide and thiocyanate 
      in milk were 0.006 mg/kg and 0.015 mg/kg, and the spiked recoveries ranged from 
      90.1% to 98.2% and from 91.8% to 98.9% with relative standard deviations (RSDs) 
      less than 18.9% and 15.2%, respectively. The proposed method was validated as a 
      simple, fast and highly sensitive method for the determination of cyanide and 
      thiocyanate in milk.
FAU - Li, Xing
AU  - Li X
AD  - Technology Center of Qinhuangdao Customs, Qinhuangdao, P.R. China.
AD  - Imported Science and Technology (Beijing) Co., Ltd, Beijing, P.R. China.
FAU - Ji, Yongyan
AU  - Ji Y
AD  - Technology Center of Qinhuangdao Customs, Qinhuangdao, P.R. China.
AD  - Department of Environmental Science & Engineering, Fudan University, Shanghai, 
      P.R. China.
FAU - Zu, Tiehong
AU  - Zu T
AD  - Technology Center of Qinhuangdao Customs, Qinhuangdao, P.R. China.
FAU - Huang, Xuezhe
AU  - Huang X
AD  - Technology Center of Qinhuangdao Customs, Qinhuangdao, P.R. China.
FAU - Wang, Jing
AU  - Wang J
AD  - Technology Center of Qinhuangdao Customs, Qinhuangdao, P.R. China.
FAU - Cao, Yanzhong
AU  - Cao Y
AD  - Technology Center of Qinhuangdao Customs, Qinhuangdao, P.R. China.
FAU - Cui, Zongyan
AU  - Cui Z
AD  - Technology Center of Qinhuangdao Customs, Qinhuangdao, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20230706
PL  - England
TA  - Food Addit Contam Part A Chem Anal Control Expo Risk Assess
JT  - Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & 
      risk assessment
JID - 101485040
RN  - 0 (Cyanides)
RN  - Z7FF1XKL7A (Cetrimonium)
RN  - O748SU14OM (thiocyanate)
RN  - 0 (Thiocyanates)
SB  - IM
MH  - Animals
MH  - *Tandem Mass Spectrometry
MH  - Gas Chromatography-Mass Spectrometry/methods
MH  - *Cyanides/analysis
MH  - Cetrimonium/analysis
MH  - Milk/chemistry
MH  - Thiocyanates/analysis
OTO - NOTNLM
OT  - Cyanide
OT  - cetyltrimethylammonium bromide (CTAB)
OT  - gas chromatography-tandem mass spectrometry (GC-MS/MS)
OT  - milk
OT  - pentafluorobenzyl bromide (PFBBr)
OT  - thiocyanate
EDAT- 2023/07/06 19:12
MHDA- 2023/08/14 06:42
CRDT- 2023/07/06 15:43
PHST- 2023/08/14 06:42 [medline]
PHST- 2023/07/06 19:12 [pubmed]
PHST- 2023/07/06 15:43 [entrez]
AID - 10.1080/19440049.2023.2227742 [doi]
PST - ppublish
SO  - Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2023 
      Aug;40(8):1025-1034. doi: 10.1080/19440049.2023.2227742. Epub 2023 Jul 6.