PMID- 37413810 OWN - NLM STAT- MEDLINE DCOM- 20230724 LR - 20230725 IS - 1532-1983 (Electronic) IS - 0261-5614 (Linking) VI - 42 IP - 8 DP - 2023 Aug TI - Dietary low- and high-quality carbohydrate intake and cognitive decline: A prospective cohort study in older adults. PG - 1322-1329 LID - S0261-5614(23)00207-8 [pii] LID - 10.1016/j.clnu.2023.06.021 [doi] AB - BACKGROUND & AIMS: The association of dietary intake of carbohydrate (CHO), especially high- and low-quality CHO, with the decline of cognitive function remains uncertain. We aimed to investigate the prospective association of dietary total, low- and high-quality CHO intake with cognitive decline, and further examine the effect of isocaloric substitution with protein or fat, in the elderly population. METHODS: A total of 3106 Chinese participants aged >/=55 years from China Health and Nutrition Survey (CHNS) were included in this study. Dietary nutrient intake information was collected by 24-h dietary recalls on 3 consecutive days. The cognitive decline was defined as the 5-year decline rates in global or composite cognitive scores based on a subset of items from the Telephone Interview for Cognitive Status-modi fi ed (TICS-m). RESULTS: The median follow-up duration was 5.9 years. There was a significantly positive association of dietary low-quality CHO (per 10 percentage energy [%E] increment, beta, 0.06; 95%CI, 0.01-0.11) and a no significant association of dietary high-quality CHO (per 10%E increment, beta, 0.04; 95%CI, -0.07-0.14) with the 5-year decline rate in the composite cognitive scores. Similar results were found for the global cognitive scores. In model simulations, substituting dietary low-quality CHO with isocaloric animal protein or fat, instead of isocaloric plant protein or fat, was significantly and inversely associated with cognitive decline (All P values < 0.05). CONCLUSIONS: The dietary intake of low-quality CHO, rather than high-quality CHO, was significantly associated with a faster cognitive decline in the elderly. In model simulations, isocaloric substitution of dietary low-quality CHO with animal protein or fat, rather than plant protein or fat, was inversely associated with cognitive decline. CI - Copyright (c) 2023. Published by Elsevier Ltd. FAU - Liu, Chengzhang AU - Liu C AD - Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou 510515, China; Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China; Institute of Biomedicine, Anhui Medical University, Hefei 230032, China. FAU - Meng, Qiguo AU - Meng Q AD - Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China; Institute of Biomedicine, Anhui Medical University, Hefei 230032, China. FAU - Zu, Cheng AU - Zu C AD - Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China; Institute of Biomedicine, Anhui Medical University, Hefei 230032, China. FAU - Wei, Yuanxiu AU - Wei Y AD - Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China; Institute of Biomedicine, Anhui Medical University, Hefei 230032, China. FAU - Su, Xinyue AU - Su X AD - Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China; Institute of Biomedicine, Anhui Medical University, Hefei 230032, China. FAU - Zhang, Yuanyuan AU - Zhang Y AD - Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou 510515, China. FAU - He, Panpan AU - He P AD - Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou 510515, China. FAU - Zhou, Chun AU - Zhou C AD - Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou 510515, China. FAU - Liu, Mengyi AU - Liu M AD - Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou 510515, China. FAU - Ye, Ziliang AU - Ye Z AD - Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou 510515, China. FAU - Qin, Xianhui AU - Qin X AD - Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou 510515, China; Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China; Institute of Biomedicine, Anhui Medical University, Hefei 230032, China. Electronic address: pharmaqin@126.com. LA - eng GR - D43 TW007709/TW/FIC NIH HHS/United States GR - D43 TW009077/TW/FIC NIH HHS/United States GR - R01 HD038700/HD/NICHD NIH HHS/United States GR - R24 HD050924/HD/NICHD NIH HHS/United States GR - P30 DK056350/DK/NIDDK NIH HHS/United States GR - R01 HD030880/HD/NICHD NIH HHS/United States GR - T32 HD007168/HD/NICHD NIH HHS/United States GR - P2C HD050924/HD/NICHD NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20230628 PL - England TA - Clin Nutr JT - Clinical nutrition (Edinburgh, Scotland) JID - 8309603 RN - 0 (Carbohydrates) RN - 0 (Plant Proteins) SB - IM MH - Aged MH - Animals MH - Humans MH - Prospective Studies MH - *Diet MH - *Cognitive Dysfunction/epidemiology MH - Carbohydrates MH - Plant Proteins OTO - NOTNLM OT - Cognitive decline OT - Isocaloric substitution OT - Low-quality carbohydrate EDAT- 2023/07/07 01:05 MHDA- 2023/07/24 06:42 CRDT- 2023/07/06 18:04 PHST- 2023/02/28 00:00 [received] PHST- 2023/05/24 00:00 [revised] PHST- 2023/06/22 00:00 [accepted] PHST- 2023/07/24 06:42 [medline] PHST- 2023/07/07 01:05 [pubmed] PHST- 2023/07/06 18:04 [entrez] AID - S0261-5614(23)00207-8 [pii] AID - 10.1016/j.clnu.2023.06.021 [doi] PST - ppublish SO - Clin Nutr. 2023 Aug;42(8):1322-1329. doi: 10.1016/j.clnu.2023.06.021. Epub 2023 Jun 28.