PMID- 37415167
OWN - NLM
STAT- MEDLINE
DCOM- 20230710
LR  - 20231119
IS  - 1479-5876 (Electronic)
IS  - 1479-5876 (Linking)
VI  - 21
IP  - 1
DP  - 2023 Jul 6
TI  - The effects of probiotics supplementation on glycaemic control among adults with 
      type 2 diabetes mellitus: a systematic review and meta-analysis of randomised 
      clinical trials.
PG  - 442
LID - 10.1186/s12967-023-04306-0 [doi]
LID - 442
AB  - OBJECTIVE: This systematic review and meta-analysis study aimed to evaluate the 
      effectiveness of probiotics supplementation on glycaemic control in patients with 
      type 2 diabetes mellitus (T2DM) based on the data from the randomised clinical 
      trials (RCTs). METHODS: PubMed, Web of Sciences, Embase, and Cochrane Library 
      were searched from the inception to October 2022, and RCTs about probiotics and 
      T2DM were collected. The standardised mean difference (SMD) with 95% confidence 
      interval (CI) was used to estimate the effects of probiotics supplementation on 
      glycaemic control related parameters, e.g. fasting blood glucose (FBG), insulin, 
      haemoglobin A1c (HbA1c), and homeostasis model of assessment of insulin 
      resistance (HOMA-IR). RESULTS: Thirty RCTs including 1,827 T2MD patients were 
      identified. Compared with the placebo group, the probiotics supplementation group 
      had a significant decrease in the parameters of glycaemic control, including FBG 
      (SMD = - 0.331, 95% CI  - 0.424 to - 0.238, P(effect) < 0.001), insulin 
      (SMD = - 0.185, 95% CI  - 0.313 to - 0.056, P(effect) = 0.005), HbA1c 
      (SMD = - 0.421, 95% CI  - 0.584 to - 0.258, P(effect) < 0.001), and HOMA-IR 
      (SMD = - 0.224, 95% CI  - 0.342 to - 0.105, P(effect) < 0.001). Further subgroup 
      analyses showed that the effect was larger in the subgroups of Caucasians, high 
      baseline body mass index (BMI >/= 30.0 kg/m(2)), Bifidobacterium and food-type 
      probiotics (P(subgroup) < 0.050). CONCLUSION: This study supported that 
      probiotics supplementation had favourable effects on glycaemic control in T2DM 
      patients. It may be a promising adjuvant therapy for patients with T2DM.
CI  - (c) 2023. The Author(s).
FAU - Li, Guang
AU  - Li G
AD  - Department of Epidemiology, School of Public Health, Sun Yat-Sen University, 
      Guangzhou, 510080, China.
FAU - Feng, Hao
AU  - Feng H
AD  - Department of Epidemiology, School of Public Health, Sun Yat-Sen University, 
      Guangzhou, 510080, China.
FAU - Mao, Xin-Liang
AU  - Mao XL
AD  - College of Food Science and Engineering, South China University of Technology, 
      Guangzhou, 510640, China.
FAU - Deng, Yan-Jun
AU  - Deng YJ
AD  - Department of Epidemiology, School of Public Health, Sun Yat-Sen University, 
      Guangzhou, 510080, China.
FAU - Wang, Xiao-Bao
AU  - Wang XB
AD  - Department of Epidemiology, School of Public Health, Sun Yat-Sen University, 
      Guangzhou, 510080, China.
FAU - Zhang, Qiong
AU  - Zhang Q
AD  - Department of Epidemiology, School of Public Health, Sun Yat-Sen University, 
      Guangzhou, 510080, China.
FAU - Guo, Yan
AU  - Guo Y
AD  - Zhongshan Center for Disease Control and Prevention, Zhongshan, 528403, China.
FAU - Xiao, Su-Mei
AU  - Xiao SM
AUID- ORCID: 0000-0003-4823-1601
AD  - Department of Epidemiology, School of Public Health, Sun Yat-Sen University, 
      Guangzhou, 510080, China. xiaosm3@mail.sysu.edu.cn.
AD  - Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of 
      Public Health, Sun Yat-Sen University, Guangzhou, 510080, China. 
      xiaosm3@mail.sysu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20230706
PL  - England
TA  - J Transl Med
JT  - Journal of translational medicine
JID - 101190741
RN  - 0 (Glycated Hemoglobin)
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
SB  - IM
MH  - Adult
MH  - Humans
MH  - Glycated Hemoglobin
MH  - Blood Glucose
MH  - Glycemic Control
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - *Probiotics/therapeutic use/pharmacology
MH  - *Insulin Resistance
MH  - Insulin/therapeutic use
MH  - Randomized Controlled Trials as Topic
PMC - PMC10324246
OTO - NOTNLM
OT  - Glycaemic control
OT  - Probiotics
OT  - Systematic review and meta- analysis
OT  - Type 2 diabetes mellitus
COIS- All the authors declare no competing interests.
EDAT- 2023/07/07 01:05
MHDA- 2023/07/10 06:42
PMCR- 2023/07/06
CRDT- 2023/07/06 23:40
PHST- 2023/03/18 00:00 [received]
PHST- 2023/06/24 00:00 [accepted]
PHST- 2023/07/10 06:42 [medline]
PHST- 2023/07/07 01:05 [pubmed]
PHST- 2023/07/06 23:40 [entrez]
PHST- 2023/07/06 00:00 [pmc-release]
AID - 10.1186/s12967-023-04306-0 [pii]
AID - 4306 [pii]
AID - 10.1186/s12967-023-04306-0 [doi]
PST - epublish
SO  - J Transl Med. 2023 Jul 6;21(1):442. doi: 10.1186/s12967-023-04306-0.