PMID- 37415911
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230718
IS  - 2296-861X (Print)
IS  - 2296-861X (Electronic)
IS  - 2296-861X (Linking)
VI  - 10
DP  - 2023
TI  - Longan extract suppresses food intake through regulation of POMC/AgRP neuronal 
      activities and endoplasmic reticulum stress in hypothalamus of db/db mice.
PG  - 1143613
LID - 10.3389/fnut.2023.1143613 [doi]
LID - 1143613
AB  - Type 2 diabetes mellitus (T2DM) is one of the biggest public health issues 
      worldwide and closely related to development of other chronic diseases such as 
      cardiovascular diseases, cancer and neurodegenerative diseases. Considerable 
      percentage of T2DM patients undergo have suffered from binge eating disorder 
      which exacerbates insulin resistance and metabolic challenges. Longan (Dimocarpus 
      longan L.) and its constituents are reported for their various health benefits. 
      However, it is still unknown whether longan fruit supplementation can ameliorate 
      glucose homeostasis and binge eating disorder found in T2DM. The current study 
      aimed to investigate whether longan fruit extract (LE) supplementation can 
      improve diabetic hyperglycemia through modulation of feeding center located in 
      hypothalamus of db/db T2DM mice. As a result, LE supplementation ameliorated 
      fasting blood glucose levels and reduced excessive epididymal fat accumulation. 
      In addition, LE administration improved glucose tolerance and insulin sensitivity 
      in db/db mice. Especially, LE supplemented mice showed less food consumption 
      which was in line with increase of pro-opiomelanocortin (POMC) neuronal 
      activities and decrease of agouti-related peptide (AgRP) neuronal activities. 
      Furthermore, LE supplementation reduced hypothalamic endoplasmic reticulum (ER) 
      stress which was stimulated in db/db mice. As ER stress is a crucial factor 
      involving in appetite control and glucose homeostasis, the effect of LE 
      supplementation on circulating glucose levels and feeding behavior might be 
      mediated by suppression of hypothalamic ER stress. Collectively, these findings 
      suggest that LE could be a potential nutraceutical for improvement of T2DM as 
      well as patients with satiety issues.
CI  - Copyright (c) 2023 Eo, Kim, Ju, Huh, Kim, Choi, Kim, Son and Oh.
FAU - Eo, Hyeyoon
AU  - Eo H
AD  - Department of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee 
      University, Seoul, Republic of Korea.
FAU - Kim, Seong Hye
AU  - Kim SH
AD  - Department of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee 
      University, Seoul, Republic of Korea.
FAU - Ju, In Gyoung
AU  - Ju IG
AD  - Department of Oriental Pharmaceutical Science, Kyung Hee University, Seoul, 
      Republic of Korea.
FAU - Huh, Eugene
AU  - Huh E
AD  - Department of Oriental Pharmaceutical Science, Kyung Hee University, Seoul, 
      Republic of Korea.
FAU - Kim, Sinyeon
AU  - Kim S
AD  - MThera Pharma Co., Seoul, Republic of Korea.
FAU - Choi, Jin Gyu
AU  - Choi JG
AD  - MThera Pharma Co., Seoul, Republic of Korea.
FAU - Kim, Se Woong
AU  - Kim SW
AD  - MThera Pharma Co., Seoul, Republic of Korea.
FAU - Son, Miwon
AU  - Son M
AD  - MThera Pharma Co., Seoul, Republic of Korea.
FAU - Oh, Myung Sook
AU  - Oh MS
AD  - Department of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee 
      University, Seoul, Republic of Korea.
AD  - Department of Oriental Pharmaceutical Science, Kyung Hee University, Seoul, 
      Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20230621
PL  - Switzerland
TA  - Front Nutr
JT  - Frontiers in nutrition
JID - 101642264
PMC - PMC10322219
OTO - NOTNLM
OT  - ER stress
OT  - POMC/AgRP
OT  - appetite
OT  - binge eating disorder
OT  - longan
OT  - type 2 diabetes
COIS- SK, JC, SWK, and MS are employed by MThera Pharma Co. The remaining authors 
      declare that the research was conducted in the absence of any commercial or 
      financial relationships that could be construed as a potential conflict of 
      interest.
EDAT- 2023/07/07 06:42
MHDA- 2023/07/07 06:43
PMCR- 2023/01/01
CRDT- 2023/07/07 04:00
PHST- 2023/01/13 00:00 [received]
PHST- 2023/06/02 00:00 [accepted]
PHST- 2023/07/07 06:43 [medline]
PHST- 2023/07/07 06:42 [pubmed]
PHST- 2023/07/07 04:00 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fnut.2023.1143613 [doi]
PST - epublish
SO  - Front Nutr. 2023 Jun 21;10:1143613. doi: 10.3389/fnut.2023.1143613. eCollection 
      2023.