PMID- 37416021
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230718
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 15
IP  - 6
DP  - 2023 Jun
TI  - A Cross-Sectional Study of the Haematological Profile of Patients With Chronic 
      Liver Disease (CLD).
PG  - e40003
LID - 10.7759/cureus.40003 [doi]
LID - e40003
AB  - The liver keeps haematological parameters normal and preserves haemostasis by 
      storing iron, vitamin B-12, and, folic acid, necessary for healthy 
      haematopoiesis. Anaemia of various aetiologies affects approximately 75% of 
      chronic liver disease (CLD) patients, specifically caused by iron deficiency, 
      hypersplenism, chronic diseases, autoimmune haemolysis, folic acid deficiency, 
      aplasticity, and as a side effect of antiviral drugs. This study sought to 
      observe the derangements in haematological parameters in patients with CLD, 
      analyse the spectrum of anaemia in patients with CLD, and predict CLD outcomes 
      utilizing Child-Pugh Score. This cross-sectional observational research was 
      carried out in the Department of General Medicine, Himalayan Institute of Medical 
      Sciences (HIMS), Dehradun, India over the course of a year. The patients with CLD 
      who were admitted to the ward participated in the study. Most patient's blood 
      pictures reported normocytic normochromic with thrombocytopenia (TCP) (28.7%), 
      macrocytic hypochromic with TCP (26%), microcytic hypochromic with TCP (13.3%) 
      and macrocytic normochromic with TCP (9.3%). The incidence of anaemia was 85.3%: 
      mild in 12.7% patients, moderate in 55.3% patients, and severe in 17.3% patients. 
      Interestingly, this study also builds upon others suggesting that 85.9% of CLD 
      patients have Class C Child-Pugh Score.
CI  - Copyright (c) 2023, Joshi et al.
FAU - Joshi, Deepika
AU  - Joshi D
AD  - Internal Medicine, Swami Rama Himalayan University, Dehradun, IND.
FAU - Akram, Mohamad
AU  - Akram M
AD  - Internal Medicine, Swami Rama Himalayan University, Dehradun, IND.
FAU - Das, Kunal
AU  - Das K
AD  - Pediatrics, Swami Rama Himalayan University, Dehradun, IND.
FAU - Kala, Mansi
AU  - Kala M
AD  - Pathology, Himalayan Institute of Medical Sciences, Swami Rama Himalayan 
      University (SRHU), Dehradun, IND.
LA  - eng
PT  - Journal Article
DEP - 20230605
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC10322163
OTO - NOTNLM
OT  - anaemia
OT  - child pugh score
OT  - chronic liver disease
OT  - haemoglobin
OT  - thrombocytopenia
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/07/07 06:42
MHDA- 2023/07/07 06:43
PMCR- 2023/06/05
CRDT- 2023/07/07 04:02
PHST- 2023/06/03 00:00 [accepted]
PHST- 2023/07/07 06:43 [medline]
PHST- 2023/07/07 06:42 [pubmed]
PHST- 2023/07/07 04:02 [entrez]
PHST- 2023/06/05 00:00 [pmc-release]
AID - 10.7759/cureus.40003 [doi]
PST - epublish
SO  - Cureus. 2023 Jun 5;15(6):e40003. doi: 10.7759/cureus.40003. eCollection 2023 Jun.