PMID- 37416040
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230718
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 15
IP  - 6
DP  - 2023 Jun
TI  - Bullous Pemphigoid and Human Leukocyte Antigen (HLA)-DQA1: A Systematic Review.
PG  - e39923
LID - 10.7759/cureus.39923 [doi]
LID - e39923
AB  - Bullous pemphigoid (BP) is an autoimmune blistering disease that mainly affects 
      the elderly. The human leukocyte antigen (HLA) system is believed to be one of 
      the genetic factors involved in the development of BP. The connection between 
      major histocompatibility complex class II, specifically HLA-DQA1, and BP remains 
      inconclusive. The objective of this review is to find potential associations 
      between BP and HLA-DQA1 alleles, identify the HLA-DQA1 alleles associated with an 
      increased or decreased risk of developing BP, and highlight literature gaps for 
      future research. The Preferred Reporting Items for Systematic Reviews and 
      Meta-Analysis (PRISMA) guidelines were used to conduct a literature review. 
      Databases used included PubMed/MEDLINE, Google Scholar, Embase, and Cochrane 
      Library. Only studies written in English and conducted after 2000 that 
      investigated the association between HLA-DQA1 and BP in human subjects were 
      included. Odds ratios were calculated from the data provided in the studies, and 
      a meta-analysis was conducted using Review Manager (The Cochrane Collaboration, 
      London, United Kingdom) and MetaXL (EpiGear International Pty Ltd., Queensland, 
      Australia) software. The systematic review found five eligible studies, and all 
      were included in the meta-analysis. Results show an increased odds for BP in the 
      HLA-DQA1*05:05 loci (odds ratio (OR) = 2.25; 95% confidence interval (CI) = 1.80, 
      2.80) and decreased odds for BP in the HLA-DQA1*02:01 loci (OR = 0.50; 95% CI = 
      0.36, 0.70). Further research is needed to confirm these findings and explore the 
      potential clinical implications for personalized medicine approaches in BP 
      patients.
CI  - Copyright (c) 2023, Hesari et al.
FAU - Hesari, Roksana
AU  - Hesari R
AD  - Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, USA.
FAU - Thibaut, Dylan
AU  - Thibaut D
AD  - Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, USA.
FAU - Schur, Nina
AU  - Schur N
AD  - Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, USA.
FAU - Thoutireddy, Shivani
AU  - Thoutireddy S
AD  - Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, USA.
FAU - Witcher, Ryan
AU  - Witcher R
AD  - Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, USA.
FAU - Julian, Elyse
AU  - Julian E
AD  - Dermatology, Leading Edge Dermatology, Plantation, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230603
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC10319936
OTO - NOTNLM
OT  - allele
OT  - bullous pemphigoid
OT  - dqa1
OT  - hla
OT  - hla-dqa1
OT  - human leukocyte antigen
OT  - meta-analysis
OT  - mhc
OT  - mhc class ii
OT  - systematic review
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/07/07 06:42
MHDA- 2023/07/07 06:43
PMCR- 2023/06/03
CRDT- 2023/07/07 04:02
PHST- 2023/05/11 00:00 [received]
PHST- 2023/06/03 00:00 [accepted]
PHST- 2023/07/07 06:43 [medline]
PHST- 2023/07/07 06:42 [pubmed]
PHST- 2023/07/07 04:02 [entrez]
PHST- 2023/06/03 00:00 [pmc-release]
AID - 10.7759/cureus.39923 [doi]
PST - epublish
SO  - Cureus. 2023 Jun 3;15(6):e39923. doi: 10.7759/cureus.39923. eCollection 2023 Jun.