PMID- 37416043
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230718
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 15
IP  - 6
DP  - 2023 Jun
TI  - Noninfectious Uveitis in Rheumatology: Patterns, Treatment, and Outcomes.
PG  - e39965
LID - 10.7759/cureus.39965 [doi]
LID - e39965
AB  - OBJECTIVES: The present study aimed to determine the pattern and cause of 
      noninfectious uveitis in rheumatology practice. The secondary objective was to 
      identify the pattern of treatment and outcomes. MATERIALS AND METHODS: This 
      retrospective cross-sectional study was conducted in the Department of 
      Rheumatology, National Hospital and Medical Centre, Lahore, Pakistan. After 
      receiving consent, electronic medical records (EMRs) of all patients with a 
      diagnosis of noninfectious uveitis (NIU) from November 2019 to January 2023 were 
      reviewed, and a total of 52 patients labeled as having noninfectious uveitis were 
      identified. The collected data included age at diagnosis, anatomical location of 
      uveitis, associated systemic disease, used medications, and outcomes. All cases 
      had been diagnosed and assessed mutually by a rheumatologist and an 
      ophthalmologist using the International Uveitis Study Group classification system 
      to classify the pattern of uveitis by location, clinical course, and laterality 
      and rule out the possibility of other ophthalmologic diseases. Disease activity 
      was defined using the Standardization of Uveitis Nomenclature (SUN) guidelines. 
      Data was analyzed on SPSS Statistics version 23 (IBM Corp, Armonk, NY, USA). 
      RESULTS: The mean age of the patients in this study was 36.02 +/- 43.31 years, 
      with 31 (59.6%) male patients. Anterior uveitis was the most common type observed 
      among the patients at 55.8%, panuveitis was found in 25%, intermediate uveitis 
      and posterior uveitis were seen in 9.6% each. Based on laterality, unilateral eye 
      involvement was identified in 53.8% of patients. Spondyloarthritis (SpA) and 
      idiopathic uveitis were observed in 34.6% and 28.8%, respectively. In this study, 
      28 (54.9%) patients were on conventional disease-modifying antirheumatic drugs 
      (cDMARDDs), and 23 (45.1%) were on biological DMARDs. In the biologics group, 82% 
      of patients were in remission in comparison to 60% in the cDMARDs group. 
      CONCLUSION: To the best of our knowledge, this is the first report 
      on noninfectious uveitis in the Pakistani population. The study concluded that 
      anterior uveitis is the most common type of uveitis and is more common in males. 
      Spondyloarthropathy is one of the most common underlying systemic diseases. Human 
      leukocyte antigen (HLA)-B27 is associated more with uveitis. Biologics are more 
      effective than cDMARDs in controlling the disease. Collaborative work between 
      different specialties resulted in early diagnosis of underlying systemic disease, 
      better management plans, and disease outcomes. To obtain further details on 
      noninfectious uveitis, a population-based study is needed in Pakistan.
CI  - Copyright (c) 2023, Younus et al.
FAU - Younus, Raheel
AU  - Younus R
AD  - Rheumatology, National Hospital and Medical Centre, Lahore, PAK.
FAU - Saeed, Muhammad A
AU  - Saeed MA
AD  - Rheumatology, Central Park Medical College, Lahore, PAK.
FAU - Arshad, Muhammad
AU  - Arshad M
AD  - Rheumatology, National Hospital and Medical Centre, Lahore, PAK.
FAU - Farman, Sumaira
AU  - Farman S
AD  - Rheumatology, National Hospital and Medical Centre, Lahore, PAK.
FAU - Ahmad, Nighat M
AU  - Ahmad NM
AD  - Rheumatology, National Hospital and Medical Centre, Lahore, PAK.
AD  - Rheumatolgy, University of Health Science, Lahore, PAK.
LA  - eng
PT  - Journal Article
DEP - 20230605
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC10320734
OTO - NOTNLM
OT  - biologic therapies
OT  - disease-modifying antirheumatic drugs (dmards)
OT  - idiopathic uveitis
OT  - non-infectious uveitis
OT  - rheumatology & autoimmune diseases
OT  - spondyloarthritis
OT  - systemic juvenile idiopathic arthritis
OT  - uveitis
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/07/07 06:42
MHDA- 2023/07/07 06:43
PMCR- 2023/06/05
CRDT- 2023/07/07 04:02
PHST- 2023/06/05 00:00 [accepted]
PHST- 2023/07/07 06:43 [medline]
PHST- 2023/07/07 06:42 [pubmed]
PHST- 2023/07/07 04:02 [entrez]
PHST- 2023/06/05 00:00 [pmc-release]
AID - 10.7759/cureus.39965 [doi]
PST - epublish
SO  - Cureus. 2023 Jun 5;15(6):e39965. doi: 10.7759/cureus.39965. eCollection 2023 Jun.