PMID- 37417706
OWN - NLM
STAT- MEDLINE
DCOM- 20231225
LR  - 20231225
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 109
IP  - 1
DP  - 2023 Dec 21
TI  - Microvascular Complications Are Associated With Coronary Collateralization in 
      Type 2 Diabetes and Chronic Occlusion.
PG  - 237-244
LID - 10.1210/clinem/dgad396 [doi]
AB  - CONTEXT: Coronary collateral (CC) vessel development appears to be protective 
      with regard to adverse cardiovascular events and survival in patients with 
      coronary chronic total occlusion (CTO). The influence of type 2 diabetes mellitus 
      (T2DM) on CC growth has been controversial. In particular, the role of diabetic 
      microvascular complications (DMC) in determining coronary collateralization has 
      not been elucidated. OBJECTIVE: To investigate whether patients with DMC 
      presented differences in CC vessel presence and grading as compared with patients 
      without DMC. METHODS: We conducted a single-center observational study, including 
      consecutive T2DM patients, without previous cardiovascular history, undergoing a 
      clinically indicated coronary angiography for chronic coronary syndrome (CCS) and 
      angiographic evidence of at least one CTO. Patients were subdivided into 2 study 
      groups according to the presence/absence of at least one DMC (neuropathy, 
      nephropathy, or retinopathy). The presence and grading of angiographically 
      visible CC development from the patent vessels to the occluded artery were 
      assessed using the Rentrop classification. RESULTS: We enrolled 157 patients 
      (mean age 68.6 +/- 9.8 years; 120 [76.4%] men). Patients with DMC (75 [47.8%]) had 
      a higher prevalence of CC (69 [92.0%] vs 62 [75.6%], P = .006) and high-grade CC 
      (55 [73.3%] vs 39 [47.6%], P = .001) compared with those without, and we found a 
      positive association between the number of DMC in each patient and the prevalence 
      of high-grade CC. CONCLUSION: Among T2DM patients with coronary CTO, the presence 
      of DMC was associated with a high CC development.
CI  - (c) The Author(s) 2023. Published by Oxford University Press on behalf of the 
      Endocrine Society. All rights reserved. For permissions, please e-mail: 
      journals.permissions@oup.com.
FAU - Gurgoglione, Filippo Luca
AU  - Gurgoglione FL
AUID- ORCID: 0000-0001-7539-5463
AD  - Department of Cardiovascular Medicine, Fondazione Policlinico Universitario A. 
      Gemelli IRCCS, 00168 Rome, Italy.
AD  - Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
FAU - Pitocco, Dario
AU  - Pitocco D
AD  - Diabetology Care Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 
      00168 Rome, Italy.
AD  - Universita Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168 Rome, Italy.
FAU - Montone, Rocco A
AU  - Montone RA
AUID- ORCID: 0000-0002-6439-1018
AD  - Department of Cardiovascular Medicine, Fondazione Policlinico Universitario A. 
      Gemelli IRCCS, 00168 Rome, Italy.
FAU - Rinaldi, Riccardo
AU  - Rinaldi R
AD  - Department of Cardiovascular Medicine, Fondazione Policlinico Universitario A. 
      Gemelli IRCCS, 00168 Rome, Italy.
FAU - Bonadonna, Riccardo C
AU  - Bonadonna RC
AD  - Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
AD  - Division of Endocrinology and Metabolic Diseases, University of Parma, 43126 
      Parma, Italy.
FAU - Magnani, Giulia
AU  - Magnani G
AUID- ORCID: 0000-0002-2852-3474
AD  - Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
FAU - Calvieri, Camilla
AU  - Calvieri C
AD  - Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, 
      La Sapienza University, 00185 Rome, Italy.
FAU - Solinas, Emilia
AU  - Solinas E
AD  - Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
FAU - Rizzi, Alessandro
AU  - Rizzi A
AD  - Diabetology Care Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 
      00168 Rome, Italy.
FAU - Tartaglione, Linda
AU  - Tartaglione L
AD  - Diabetology Care Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 
      00168 Rome, Italy.
FAU - Flex, Andrea
AU  - Flex A
AD  - Universita Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168 Rome, Italy.
FAU - Viti, Luca
AU  - Viti L
AD  - Diabetology Care Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 
      00168 Rome, Italy.
FAU - Trani, Carlo
AU  - Trani C
AUID- ORCID: 0000-0001-9777-013X
AD  - Department of Cardiovascular Medicine, Fondazione Policlinico Universitario A. 
      Gemelli IRCCS, 00168 Rome, Italy.
FAU - Ardissino, Diego
AU  - Ardissino D
AD  - Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
FAU - Crea, Filippo
AU  - Crea F
AD  - Department of Cardiovascular Medicine, Fondazione Policlinico Universitario A. 
      Gemelli IRCCS, 00168 Rome, Italy.
FAU - Niccoli, Giampaolo
AU  - Niccoli G
AUID- ORCID: 0000-0002-3187-6262
AD  - Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
SB  - IM
MH  - Male
MH  - Humans
MH  - Middle Aged
MH  - Aged
MH  - Female
MH  - *Diabetes Mellitus, Type 2/complications
MH  - *Coronary Occlusion/complications/epidemiology
MH  - Risk Factors
MH  - Collateral Circulation
MH  - *Percutaneous Coronary Intervention
MH  - Coronary Angiography/adverse effects
MH  - Chronic Disease
OTO - NOTNLM
OT  - chronic total occlusion
OT  - coronary collaterals
OT  - diabetic microvascular complications
OT  - type 2 diabetes mellitus
EDAT- 2023/07/07 13:05
MHDA- 2023/12/25 06:42
CRDT- 2023/07/07 08:33
PHST- 2022/11/04 00:00 [received]
PHST- 2023/12/25 06:42 [medline]
PHST- 2023/07/07 13:05 [pubmed]
PHST- 2023/07/07 08:33 [entrez]
AID - 7220961 [pii]
AID - 10.1210/clinem/dgad396 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2023 Dec 21;109(1):237-244. doi: 10.1210/clinem/dgad396.