PMID- 37418866
OWN - NLM
STAT- Publisher
LR  - 20230707
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 262
DP  - 2023 Jul 5
TI  - Association between prenatal exposure to perfluoroalkyl substance mixtures and 
      intrauterine growth restriction risk: A large, nested case-control study in 
      Guangxi, China.
PG  - 115209
LID - S0147-6513(23)00713-3 [pii]
LID - 10.1016/j.ecoenv.2023.115209 [doi]
AB  - Intrauterine growth restriction (IUGR) is an abnormal fetal growth pattern that 
      can lead to neonatal morbidity and mortality. IUGR may be affected by prenatal 
      exposure to environmental pollutants, including perfluoroalkyl substances 
      (PFASs). However, research linking PFAS exposure to IUGR is limited, with 
      inconsistent results. We aimed to investigate the association between PFAS 
      exposure and IUGR by using nested casecontrol study based on Guangxi Zhuang Birth 
      Cohort (GZBC), in Guangxi, China. A total of 200 IUGR cases and 600 controls were 
      enrolled in this study. The maternal serum concentrations of nine PFASs were 
      measured using ultrahigh-performance liquid chromatography-tandem mass 
      spectrometry (UPLCMS). The associations single and mixed effects of prenatal PFAS 
      exposure on IUGR risk were assessed using conditional logistic regression 
      (single-exposure), Bayesian kernel machine regression (BKMR) and quantile 
      g-computation (qgcomp) models. In the conditional logistic regression models, the 
      log10-transformed concentrations of perfluoroheptanoic acid (PFHpA, adjusted OR: 
      4.41, 95% CI: 3.03-6.41), perfluorododecanoic acid (PFDoA, adjusted OR: 1.94, 95% 
      CI: 1.14-3.32), and perfluorohexanesulfonate (PFHxS, adjusted OR: 1.83, 95% CI: 
      1.15-2.91) were positively associated with risk of IUGR. In the BKMR models, the 
      combined effect of PFASs was positively associated with IUGR risk. In the qgcomp 
      models, we also found an increased IUGR risk (OR=5.92, 95% CI: 2.33-15.06) when 
      all nine PFASs increased by one tertile as a whole, and PFHpA (43.9%) contributed 
      the largest positive weights. These findings suggested prenatal exposure to 
      single and mixtures of PFASs may increase IUGR risk, with the effect being 
      largely driven by the PFHpA concentration.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Chen, Chenchun
AU  - Chen C
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, Nanning 530021, China.
FAU - Song, Yanye
AU  - Song Y
AD  - The Third Affiliated Hospital of Guangxi Medical University, Nanning 530031, 
      China.
FAU - Tang, Peng
AU  - Tang P
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, Nanning 530021, China.
FAU - Pan, Dongxiang
AU  - Pan D
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, Nanning 530021, China.
FAU - Wei, Bincai
AU  - Wei B
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, Nanning 530021, China.
FAU - Liang, Jun
AU  - Liang J
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, Nanning 530021, China.
FAU - Sheng, Yonghong
AU  - Sheng Y
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, Nanning 530021, China.
FAU - Liao, Qian
AU  - Liao Q
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, Nanning 530021, China.
FAU - Huang, Dongping
AU  - Huang D
AD  - Department of Sanitary Chemistry, School of Public Health, Guangxi Medical 
      University, Nanning 530021, China. Electronic address: dongpinghuang@gxmu.edu.cn.
FAU - Liu, Shun
AU  - Liu S
AD  - Department of Child and Adolescent Health & Maternal and Child Health, School of 
      Public Health, Guangxi Medical University, Nanning 530021, China. Electronic 
      address: liushun@gxmu.edu.cn.
FAU - Qiu, Xiaoqiang
AU  - Qiu X
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, Nanning 530021, China. Electronic address: 
      xqqiu9999@163.com.
LA  - eng
PT  - Journal Article
DEP - 20230705
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
SB  - IM
OTO - NOTNLM
OT  - Bayesian kernel machine regression
OT  - Guangxi Zhuang birth cohort
OT  - Intrauterine growth restriction
OT  - Perfluoroalkyl substances
OT  - Quantile g-computation
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/07/08 10:42
MHDA- 2023/07/08 10:42
CRDT- 2023/07/07 18:04
PHST- 2023/02/23 00:00 [received]
PHST- 2023/06/07 00:00 [revised]
PHST- 2023/06/28 00:00 [accepted]
PHST- 2023/07/08 10:42 [medline]
PHST- 2023/07/08 10:42 [pubmed]
PHST- 2023/07/07 18:04 [entrez]
AID - S0147-6513(23)00713-3 [pii]
AID - 10.1016/j.ecoenv.2023.115209 [doi]
PST - aheadofprint
SO  - Ecotoxicol Environ Saf. 2023 Jul 5;262:115209. doi: 10.1016/j.ecoenv.2023.115209.