PMID- 37419031
OWN - NLM
STAT- MEDLINE
DCOM- 20230815
LR  - 20230815
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 674
DP  - 2023 Sep 24
TI  - Olfactory imprinting enhances associative learning and memory in C. elegans.
PG  - 109-116
LID - S0006-291X(23)00850-1 [pii]
LID - 10.1016/j.bbrc.2023.07.002 [doi]
AB  - Learning and memory are fundamental processes for an organism's normal 
      physiological function. Learning can occur at any stage of the organism's 
      physiological development. Imprinted memories formed during the early 
      developmental stage, unlike learning and memory, can last a lifetime. It is not 
      clear whether these two types of memories are interlinked. In this study, we 
      investigated whether imprinted memory influences adult learning and memory in a 
      C. elegans model system. We trained the worms for short-term (STAM) and long-term 
      associated memory (LTAM) towards butanone (BT) after conditioning them for 
      imprinted memory towards isoamyl alcohol (IAA). We observed that these worms had 
      improved learning abilities. However, functional imaging revealed that the worms 
      had a long-term depression in the firing pattern in the AIY interneuron, 
      indicating that there were significant changes in neuronal excitation pattern 
      after imprinting, which could explain the enhanced behavioural alterations in 
      animals after imprinting.
CI  - Copyright (c) 2023 Elsevier Inc. All rights reserved.
FAU - Mangalath, Aswathy
AU  - Mangalath A
AD  - Division of Molecular Medicine, Sree Chitra Tirunal Institute for Medical 
      Sciences and Technology, Trivandrum, Kerala, 695012, India.
FAU - Thekkuveettil, Anoopkumar
AU  - Thekkuveettil A
AD  - Division of Molecular Medicine, Sree Chitra Tirunal Institute for Medical 
      Sciences and Technology, Trivandrum, Kerala, 695012, India. Electronic address: 
      anoop@sctimst.ac.in.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230703
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
SB  - IM
MH  - Animals
MH  - *Caenorhabditis elegans/physiology
MH  - *Memory, Long-Term/physiology
MH  - Learning
MH  - Smell/physiology
MH  - Conditioning, Classical
OTO - NOTNLM
OT  - Learning and memory
OT  - Olfactory imprinting
OT  - Short-term associated memory and long-term associated memory
COIS- Declaration of competing interest The authors declare no conflict of interest.
EDAT- 2023/07/08 10:42
MHDA- 2023/08/15 06:42
CRDT- 2023/07/07 18:08
PHST- 2023/05/31 00:00 [received]
PHST- 2023/07/01 00:00 [accepted]
PHST- 2023/08/15 06:42 [medline]
PHST- 2023/07/08 10:42 [pubmed]
PHST- 2023/07/07 18:08 [entrez]
AID - S0006-291X(23)00850-1 [pii]
AID - 10.1016/j.bbrc.2023.07.002 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2023 Sep 24;674:109-116. doi: 
      10.1016/j.bbrc.2023.07.002. Epub 2023 Jul 3.