PMID- 37419076
OWN - NLM
STAT- MEDLINE
DCOM- 20230814
LR  - 20230816
IS  - 1558-1497 (Electronic)
IS  - 0197-4580 (Linking)
VI  - 130
DP  - 2023 Oct
TI  - Perirhinal cortex is associated with fine-grained discrimination of conceptually 
      confusable objects in Alzheimer's disease.
PG  - 1-11
LID - S0197-4580(23)00119-7 [pii]
LID - 10.1016/j.neurobiolaging.2023.06.003 [doi]
AB  - The perirhinal cortex (PrC) stands among the first brain areas to deteriorate in 
      Alzheimer's disease (AD). This study tests to what extent the PrC is involved in 
      representing and discriminating confusable objects based on the conjunction of 
      their perceptual and conceptual features. To this aim, AD patients and control 
      counterparts performed 3 tasks: a naming, a recognition memory, and a conceptual 
      matching task, where we manipulated conceptual and perceptual confusability. A 
      structural MRI of the antero-lateral parahippocampal subregions was obtained for 
      each participant. We found that the sensitivity to conceptual confusability was 
      associated with the left PrC volume in both AD patients and control participants 
      for the recognition memory task, while it was specifically associated with the 
      volume of the left PrC in AD patients for the conceptual matching task. This 
      suggests that a decreased volume of the PrC is related to the ability to 
      disambiguate conceptually confusable items. Therefore, testing recognition memory 
      or conceptual matching of easily conceptually confusable items can provide a 
      potential cognitive marker of PrC atrophy.
CI  - Copyright (c) 2023 Elsevier Inc. All rights reserved.
FAU - Frick, Aurelien
AU  - Frick A
AD  - GIGA-CRC In Vivo Imaging, University of Liege, Liege, Belgium; Psychology and 
      Neuroscience of Cognition Research Unit, University of Liege, Liege, Belgium. 
      Electronic address: aurelien.frick@hotmail.com.
FAU - Besson, Gabriel
AU  - Besson G
AD  - CINEICC, Faculty of Psychology and Educational Sciences, University of 
      Coimbra, Coimbra, Portugal.
FAU - Salmon, Eric
AU  - Salmon E
AD  - GIGA-CRC In Vivo Imaging, University of Liege, Liege, Belgium.
FAU - Delhaye, Emma
AU  - Delhaye E
AD  - GIGA-CRC In Vivo Imaging, University of Liege, Liege, Belgium; Psychology and 
      Neuroscience of Cognition Research Unit, University of Liege, Liege, Belgium.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230609
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
SB  - IM
MH  - Humans
MH  - *Perirhinal Cortex
MH  - *Alzheimer Disease/psychology
MH  - Magnetic Resonance Imaging
MH  - Recognition, Psychology
MH  - Brain
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Conceptual distance
OT  - Episodic memory
OT  - Perceptual distance
OT  - Perirhinal cortex
OT  - Semantic memory
COIS- Disclosure statement The authors declare no conflict of interest.
EDAT- 2023/07/08 10:42
MHDA- 2023/08/14 06:43
CRDT- 2023/07/07 18:11
PHST- 2022/12/02 00:00 [received]
PHST- 2023/06/01 00:00 [revised]
PHST- 2023/06/03 00:00 [accepted]
PHST- 2023/08/14 06:43 [medline]
PHST- 2023/07/08 10:42 [pubmed]
PHST- 2023/07/07 18:11 [entrez]
AID - S0197-4580(23)00119-7 [pii]
AID - 10.1016/j.neurobiolaging.2023.06.003 [doi]
PST - ppublish
SO  - Neurobiol Aging. 2023 Oct;130:1-11. doi: 10.1016/j.neurobiolaging.2023.06.003. 
      Epub 2023 Jun 9.