PMID- 37419158
OWN - NLM
STAT- MEDLINE
DCOM- 20230809
LR  - 20230809
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 338
DP  - 2023 Oct
TI  - Exposure to volatile organic compounds is a risk factor for diabetes: A 
      cross-sectional study.
PG  - 139424
LID - S0045-6535(23)01691-0 [pii]
LID - 10.1016/j.chemosphere.2023.139424 [doi]
AB  - Currently, more studies showed that environmental chemicals were associated with 
      the development of diabetes. However, the effect of volatile organic compounds 
      (VOCs) on diabetes remained uncertain and needed to be studied. This 
      cross-sectional study examined whether exposure to low levels of VOCs was 
      associated with diabetes, insulin resistance (TyG index) and glucose-related 
      indicators (FPG,HbA1c, insulin) in the general population by using the NHANES 
      dataset (2013-2014 and 2015-2016). We analyzed the association between urinary 
      VOC metabolism (mVOCs) and these indicators in 1409 adults by multiple linear 
      regression models or logistic regression models, further Bayesian kernel machine 
      regression (BKMR) models were performed for mixture exposure analysis. The 
      results showed positive associations between multiple mVOCs and diabetes, TyG 
      index, FPG, HbA1c and insulin, respectively. Among them, HPMMA concentration in 
      urine was significantly positively correlated with diabetes and related 
      indicators (TyG index, FPG and HbA1c), and the concentration of CEMA was 
      significantly positively correlated with insulin. The positive association of 
      mVOCs with diabetes and its related indicators was more significant in the female 
      group and in the 40-59 years group. Thus, our study suggested that exposure to 
      VOCs affected insulin resistance and glucose homeostasis, further affecting 
      diabetes levels, which had important public health implications.
CI  - Copyright (c) 2023 Elsevier Ltd. All rights reserved.
FAU - Wang, Xueting
AU  - Wang X
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Capital Medical University, 100069, Beijing, China; Beijing Key 
      Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 
      100069, China.
FAU - He, Weifeng
AU  - He W
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Capital Medical University, 100069, Beijing, China; Beijing Key 
      Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 
      100069, China.
FAU - Wu, Xiaojuan
AU  - Wu X
AD  - Department of Endocrinology, Fu Xing Hospital, Capital Medical University, 
      100038, Beijing, China.
FAU - Song, Xin
AU  - Song X
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Capital Medical University, 100069, Beijing, China; Beijing Key 
      Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 
      100069, China.
FAU - Yang, Xin
AU  - Yang X
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Capital Medical University, 100069, Beijing, China; Beijing Key 
      Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 
      100069, China.
FAU - Zhang, Gaoman
AU  - Zhang G
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Capital Medical University, 100069, Beijing, China; Beijing Key 
      Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 
      100069, China.
FAU - Niu, Piye
AU  - Niu P
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Capital Medical University, 100069, Beijing, China; Beijing Key 
      Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 
      100069, China. Electronic address: niupiye@ccmu.edu.cn.
FAU - Chen, Tian
AU  - Chen T
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Capital Medical University, 100069, Beijing, China; Beijing Key 
      Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 
      100069, China. Electronic address: chentian@ccmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20230705
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Volatile Organic Compounds)
RN  - 0 (Glycated Hemoglobin)
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - IY9XDZ35W2 (Glucose)
RN  - 0 (Triglycerides)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Humans
MH  - Female
MH  - *Volatile Organic Compounds/toxicity
MH  - *Insulin Resistance
MH  - Cross-Sectional Studies
MH  - Glycated Hemoglobin
MH  - Blood Glucose/analysis
MH  - Nutrition Surveys
MH  - Bayes Theorem
MH  - Risk Factors
MH  - Insulin
MH  - Glucose
MH  - Triglycerides
MH  - Biomarkers/analysis
MH  - *Diabetes Mellitus/epidemiology
OTO - NOTNLM
OT  - Diabetes
OT  - Glucose-related indicator
OT  - Metabolite of volatile organic compounds
OT  - TyG index
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/07/08 10:42
MHDA- 2023/08/09 06:43
CRDT- 2023/07/07 19:22
PHST- 2023/04/25 00:00 [received]
PHST- 2023/06/26 00:00 [revised]
PHST- 2023/07/04 00:00 [accepted]
PHST- 2023/08/09 06:43 [medline]
PHST- 2023/07/08 10:42 [pubmed]
PHST- 2023/07/07 19:22 [entrez]
AID - S0045-6535(23)01691-0 [pii]
AID - 10.1016/j.chemosphere.2023.139424 [doi]
PST - ppublish
SO  - Chemosphere. 2023 Oct;338:139424. doi: 10.1016/j.chemosphere.2023.139424. Epub 
      2023 Jul 5.