PMID- 37419247 OWN - NLM STAT- MEDLINE DCOM- 20231113 LR - 20231122 IS - 1916-7075 (Electronic) IS - 0828-282X (Linking) VI - 39 IP - 11 DP - 2023 Nov TI - Vascular Complications in Transcatheter Aortic Valve Replacement With Plug-Based vs Suture-Based Closure Devices. PG - 1528-1534 LID - S0828-282X(23)01466-6 [pii] LID - 10.1016/j.cjca.2023.06.425 [doi] AB - BACKGROUND: There are conflicting data regarding the efficacy and safety of suture vs plug-based vascular closure devices (VCDs) for large-bore catheter management in patients undergoing transcatheter aortic valve replacement (TAVR). We compared the rates of vascular complications (VCs) associated with 2 commonly used VCDs in a large cohort of patients undergoing TAVR. METHODS: We conducted a single-centre, all-comer, prospective registry study, enrolling patients undergoing TAVR for symptomatic severe aortic stenosis (AS) between the years 2009 and 2022. Clinical outcomes were compared between patients undergoing closure of the femoral access point using the MANTA VCD (M-VCD) (Teleflex, Wayne, PA) vs the ProGlide VCD (P-VCD) (Abbott Vascular, Abbott Park, IL). The main outcome measures were researcher adjudicated events of VARC-2 defined major and minor VCs. RESULTS: Overall, 2368 patients were enrolled in the registry; 1315 (51.0% male, 81.0 +/- 7.0 years) patients were included in the current analysis. P-VCD was used in 813 patients, whereas M-VCD was used in 502 patients. In-hospital VCs were more frequent in the M-VCD vs the P-VCD group (17.3% vs 9.8%; P < 0.001). This outcome was mainly driven by elevated rates of minor VCs in the M-VCD group, whereas no significant difference was observed for major VCs (15.1% vs 8.4%; P < 0.001 and 2.2% vs 1.5%; P = 0.33, respectively). CONCLUSIONS: In patients undergoing TAVR for severe AS, M-VCD was associated with higher rates of VCs. This outcome was mainly driven by minor VCs. The rate of major VCs was low in both groups. CI - Copyright (c) 2023 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved. FAU - Zornitzki, Lior AU - Zornitzki L AD - Department of Cardiology, Tel Aviv Sourasky Medical Center, affiliated with the School of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Internal Medicine B, Tel Aviv Sourasky Medical Center, affiliated with the School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: Lior.zoz@gmail.com. FAU - Zahler, David AU - Zahler D AD - Department of Cardiology, Tel Aviv Sourasky Medical Center, affiliated with the School of Medicine, Tel Aviv University, Tel Aviv, Israel. FAU - Frydman, Shir AU - Frydman S AD - Department of Cardiology, Tel Aviv Sourasky Medical Center, affiliated with the School of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Internal Medicine B, Tel Aviv Sourasky Medical Center, affiliated with the School of Medicine, Tel Aviv University, Tel Aviv, Israel. FAU - Itach, Tamar AU - Itach T AD - Department of Cardiology, Tel Aviv Sourasky Medical Center, affiliated with the School of Medicine, Tel Aviv University, Tel Aviv, Israel. FAU - Ben-Shoshan, Jeremy AU - Ben-Shoshan J AD - Department of Cardiology, Tel Aviv Sourasky Medical Center, affiliated with the School of Medicine, Tel Aviv University, Tel Aviv, Israel. FAU - Halkin, Amir AU - Halkin A AD - Department of Cardiology, Tel Aviv Sourasky Medical Center, affiliated with the School of Medicine, Tel Aviv University, Tel Aviv, Israel. FAU - Bazan, Samuel AU - Bazan S AD - Department of Cardiology, Tel Aviv Sourasky Medical Center, affiliated with the School of Medicine, Tel Aviv University, Tel Aviv, Israel. FAU - Arbel, Yaron AU - Arbel Y AD - Department of Cardiology, Tel Aviv Sourasky Medical Center, affiliated with the School of Medicine, Tel Aviv University, Tel Aviv, Israel. FAU - Konigstein, Maayan AU - Konigstein M AD - Department of Cardiology, Tel Aviv Sourasky Medical Center, affiliated with the School of Medicine, Tel Aviv University, Tel Aviv, Israel. FAU - Finkelstein, Ariel AU - Finkelstein A AD - Department of Cardiology, Tel Aviv Sourasky Medical Center, affiliated with the School of Medicine, Tel Aviv University, Tel Aviv, Israel. FAU - Banai, Shmuel AU - Banai S AD - Department of Cardiology, Tel Aviv Sourasky Medical Center, affiliated with the School of Medicine, Tel Aviv University, Tel Aviv, Israel. FAU - Steinvil, Arie AU - Steinvil A AD - Department of Cardiology, Tel Aviv Sourasky Medical Center, affiliated with the School of Medicine, Tel Aviv University, Tel Aviv, Israel. LA - eng PT - Journal Article DEP - 20230705 PL - England TA - Can J Cardiol JT - The Canadian journal of cardiology JID - 8510280 SB - IM MH - Humans MH - Male MH - Female MH - *Transcatheter Aortic Valve Replacement/adverse effects MH - Treatment Outcome MH - Femoral Artery/surgery MH - *Vascular Closure Devices/adverse effects MH - *Cardiovascular Diseases/etiology MH - *Aortic Valve Stenosis/surgery/etiology MH - Aortic Valve/surgery MH - Hemostatic Techniques/adverse effects EDAT- 2023/07/08 10:42 MHDA- 2023/11/13 06:42 CRDT- 2023/07/07 19:25 PHST- 2023/02/06 00:00 [received] PHST- 2023/06/27 00:00 [revised] PHST- 2023/06/29 00:00 [accepted] PHST- 2023/11/13 06:42 [medline] PHST- 2023/07/08 10:42 [pubmed] PHST- 2023/07/07 19:25 [entrez] AID - S0828-282X(23)01466-6 [pii] AID - 10.1016/j.cjca.2023.06.425 [doi] PST - ppublish SO - Can J Cardiol. 2023 Nov;39(11):1528-1534. doi: 10.1016/j.cjca.2023.06.425. Epub 2023 Jul 5.