PMID- 37419338 OWN - NLM STAT- MEDLINE DCOM- 20230925 LR - 20230925 IS - 1879-1026 (Electronic) IS - 0048-9697 (Linking) VI - 897 DP - 2023 Nov 1 TI - Associations of accumulated persistent organic pollutants in breast adipose tissue with the evolution of breast cancer after surgery. PG - 165373 LID - S0048-9697(23)03996-7 [pii] LID - 10.1016/j.scitotenv.2023.165373 [doi] AB - Chronic exposure to persistent organic pollutants (POPs) is suspected to contribute to the onset of breast cancer, but the impact on the evolution of patients after diagnosis is unclear. We aimed to analyze the contribution of long-term exposure to five POPs to overall mortality, cancer recurrence, metastasis, and development of second primary tumors over a global follow-up of 10 years after surgery in breast cancer patients in a cohort study. Between 2012 and 2014, a total of 112 newly diagnosed breast cancer patients were recruited from a public hospital in Granada, Southern Spain. Historical exposure to POPs was estimated by analyzing their concentrations in breast adipose tissue samples. Sociodemographic data were collected through face-to-face interviews, while data on evolution tumor were retrieved from clinical records. Statistical analyses were performed using Cox regression (overall survival, breast cancer recurrence or metastasis) and binary logistic regression models (joint outcome variable). We also tested for statistical interactions of POPs with age, residence, and prognostic markers. The third vs first tertile of hexachlorobenzene concentrations was associated with a lower risk of all-cause mortality (Hazard Ratio, HR = 0.26; 95 % Confidence Interval, CI = 0.07-0.92) and of the appearance of any of the four events (Odds Ratio = 0.37; 95 % CI = 0.14-1.03). Polychlorinated biphenyl 138 concentrations were significantly and inversely associated with risk of metastasis (HR = 0.65; 95 % CI = 0.44-0.97) and tumor recurrence (HR = 0.69; 95 % CI = 0.49-0.98). Additionally, p,p'-dichlorodiphenyldichloroethylene showed inverse associations with risk of metastasis in women with ER-positive tumors (HR = 0.49; 95 % CI = 0.25-0.93) and in those with a tumor size <2.0 cm (HR = 0.39; 95 % CI = 0.18-0.87). The observed paradoxical inverse associations of POP exposure with breast cancer evolution might be related to either a better prognosis of hormone-dependent tumors, which have an approachable pharmacological target, or an effect of sequestration of circulating POPs by adipose tissue. CI - Copyright (c) 2023 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Barrios-Rodriguez, R AU - Barrios-Rodriguez R AD - Universidad de Granada, Departamento de Medicina Preventiva y Salud Publica, Granada, Spain; Instituto de Investigacion Biosanitaria ibs.GRANADA, Granada, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain. FAU - Garde, C AU - Garde C AD - San Cecilio University Hospital, Avenida del Conocimiento s/n, 18016 Granada, Spain. FAU - Perez-Carrascosa, F M AU - Perez-Carrascosa FM AD - Universidad de Granada, Departamento de Medicina Preventiva y Salud Publica, Granada, Spain; Instituto de Investigacion Biosanitaria ibs.GRANADA, Granada, Spain. FAU - Exposito, J AU - Exposito J AD - Instituto de Investigacion Biosanitaria ibs.GRANADA, Granada, Spain; Virgen de las Nieves University Hospital, Radiation Oncology Department, Oncology Unit, Granada, Spain. FAU - Peinado, F M AU - Peinado FM AD - Instituto de Investigacion Biosanitaria ibs.GRANADA, Granada, Spain. FAU - Fernandez Rodriguez, M AU - Fernandez Rodriguez M AD - Universidad de Granada, Facultad de Farmacia, Departamento de Farmacia y Tecnologia Farmaceutica, Granada, Spain. FAU - Requena, P AU - Requena P AD - Universidad de Granada, Departamento de Medicina Preventiva y Salud Publica, Granada, Spain; Instituto de Investigacion Biosanitaria ibs.GRANADA, Granada, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain. FAU - Salcedo-Bellido, I AU - Salcedo-Bellido I AD - Universidad de Granada, Departamento de Medicina Preventiva y Salud Publica, Granada, Spain; Instituto de Investigacion Biosanitaria ibs.GRANADA, Granada, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain. Electronic address: isalcedo@ugr.es. FAU - Arrebola, J P AU - Arrebola JP AD - Universidad de Granada, Departamento de Medicina Preventiva y Salud Publica, Granada, Spain; Instituto de Investigacion Biosanitaria ibs.GRANADA, Granada, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain. Electronic address: jparrebola@ugr.es. LA - eng PT - Journal Article DEP - 20230705 PL - Netherlands TA - Sci Total Environ JT - The Science of the total environment JID - 0330500 RN - 0 (Persistent Organic Pollutants) RN - 0 (Environmental Pollutants) RN - DFC2HB4I0K (Polychlorinated Biphenyls) RN - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene) RN - 0 (Hydrocarbons, Chlorinated) SB - IM MH - Humans MH - Female MH - Persistent Organic Pollutants MH - *Breast Neoplasms/epidemiology MH - Cohort Studies MH - Neoplasm Recurrence, Local/epidemiology MH - *Environmental Pollutants MH - *Polychlorinated Biphenyls MH - Dichlorodiphenyl Dichloroethylene MH - Adipose Tissue MH - *Hydrocarbons, Chlorinated OTO - NOTNLM OT - Adipose tissue OT - All-cause mortality OT - Breast cancer recurrence OT - Metastasis OT - Persistent organic pollutants OT - Second primary tumor COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/07/08 10:42 MHDA- 2023/09/25 06:42 CRDT- 2023/07/07 19:27 PHST- 2023/03/30 00:00 [received] PHST- 2023/07/04 00:00 [revised] PHST- 2023/07/05 00:00 [accepted] PHST- 2023/09/25 06:42 [medline] PHST- 2023/07/08 10:42 [pubmed] PHST- 2023/07/07 19:27 [entrez] AID - S0048-9697(23)03996-7 [pii] AID - 10.1016/j.scitotenv.2023.165373 [doi] PST - ppublish SO - Sci Total Environ. 2023 Nov 1;897:165373. doi: 10.1016/j.scitotenv.2023.165373. Epub 2023 Jul 5.