PMID- 37419416
OWN - NLM
STAT- MEDLINE
DCOM- 20230814
LR  - 20230823
IS  - 1995-820X (Electronic)
IS  - 1674-0769 (Print)
IS  - 1995-820X (Linking)
VI  - 38
IP  - 4
DP  - 2023 Aug
TI  - Host cell restriction factors of equine infectious anemia virus.
PG  - 485-496
LID - S1995-820X(23)00081-0 [pii]
LID - 10.1016/j.virs.2023.07.001 [doi]
AB  - Equine infectious anemia virus (EIAV) is a member of the lentivirus genus in the 
      Retroviridae family and is considered an animal model for HIV/AIDS research. An 
      attenuated EIAV vaccine, which was successfully developed in the 1970s by 
      classical serial passage techniques, is the first and only lentivirus vaccine 
      that has been widely used to date. Restriction factors are cellular proteins that 
      provide an early line of defense against viral replication and spread by 
      interfering with various critical steps in the viral replication cycle. However, 
      viruses have evolved specific mechanisms to overcome these host barriers through 
      adaptation. The battle between the viruses and restriction factors is actually a 
      natural part of the viral replication process, which has been well studied in 
      human immunodeficiency virus type 1 (HIV-1). EIAV has the simplest genome 
      composition of all lentiviruses, making it an intriguing subject for 
      understanding how the virus employs its limited viral proteins to overcome 
      restriction factors. In this review, we summarize the current literature on the 
      interactions between equine restriction factors and EIAV. The features of equine 
      restriction factors and the mechanisms by which the EIAV counteract the 
      restriction suggest that lentiviruses employ diverse strategies to counteract 
      innate immune restrictions. In addition, we present our insights on whether 
      restriction factors induce alterations in the phenotype of the attenuated EIAV 
      vaccine.
CI  - Copyright (c) 2023 The Authors. Publishing services by Elsevier B.V. All rights 
      reserved.
FAU - Wang, Xue-Feng
AU  - Wang XF
AD  - State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary 
      Research Institute of Chinese Academy of Agricultural Sciences, Harbin 150069, 
      China.
FAU - Zhang, Xiangmin
AU  - Zhang X
AD  - State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary 
      Research Institute of Chinese Academy of Agricultural Sciences, Harbin 150069, 
      China.
FAU - Ma, Weiwei
AU  - Ma W
AD  - State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary 
      Research Institute of Chinese Academy of Agricultural Sciences, Harbin 150069, 
      China.
FAU - Li, Jiwei
AU  - Li J
AD  - State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary 
      Research Institute of Chinese Academy of Agricultural Sciences, Harbin 150069, 
      China.
FAU - Wang, Xiaojun
AU  - Wang X
AD  - State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary 
      Research Institute of Chinese Academy of Agricultural Sciences, Harbin 150069, 
      China. Electronic address: wangxiaojun@caas.cn.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230705
PL  - Netherlands
TA  - Virol Sin
JT  - Virologica Sinica
JID - 101514185
RN  - 0 (Antiviral Restriction Factors)
RN  - 0 (Viral Proteins)
SB  - IM
MH  - Horses
MH  - Animals
MH  - Humans
MH  - *Infectious Anemia Virus, Equine/genetics
MH  - Antiviral Restriction Factors
MH  - Viral Proteins/metabolism
MH  - Virus Replication
MH  - *HIV-1/genetics
PMC - PMC10436108
OTO - NOTNLM
OT  - Equine infectious anemia virus (EIAV)
OT  - Lentivirus
OT  - Restriction factor
COIS- Conflict of interest The authors declare that there are no conflicts of interest.
EDAT- 2023/07/08 10:42
MHDA- 2023/08/14 06:41
PMCR- 2023/07/05
CRDT- 2023/07/07 19:28
PHST- 2023/04/13 00:00 [received]
PHST- 2023/07/03 00:00 [accepted]
PHST- 2023/08/14 06:41 [medline]
PHST- 2023/07/08 10:42 [pubmed]
PHST- 2023/07/07 19:28 [entrez]
PHST- 2023/07/05 00:00 [pmc-release]
AID - S1995-820X(23)00081-0 [pii]
AID - 10.1016/j.virs.2023.07.001 [doi]
PST - ppublish
SO  - Virol Sin. 2023 Aug;38(4):485-496. doi: 10.1016/j.virs.2023.07.001. Epub 2023 Jul 
      5.