PMID- 37421440
OWN - NLM
STAT- MEDLINE
DCOM- 20230927
LR  - 20240402
IS  - 1432-5233 (Electronic)
IS  - 0940-5429 (Linking)
VI  - 60
IP  - 11
DP  - 2023 Nov
TI  - Does nutritional guidance reduce cardiovascular events in patients with type 2 
      diabetes mellitus? A retrospective cohort study using a nationwide claims 
      database.
PG  - 1541-1549
LID - 10.1007/s00592-023-02147-3 [doi]
AB  - AIM: To examine the effect of nutritional guidance (NG) provided by a registered 
      dietitian under the direction of a physician on the development of subsequent 
      cardiovascular events in patients with early-stage type 2 diabetes mellitus 
      (T2DM). MATERIALS AND METHODS: This retrospective cohort study used the JMDC 
      claims database to explore patients aged 18 years or older who first met the 
      diagnostic criteria for T2DM at a health checkup between January 2011 and January 
      2019. The last day of the observation period was set for 28 February, 2021. 
      Exposure was defined as receiving NG within 180 days of diagnosis of T2DM. The 
      primary outcome was a composite endpoint of coronary artery disease (CAD) and 
      cerebrovascular disease, and the secondary outcomes were each event, and time to 
      event was compared. The propensity score weighting method was used for adjusting 
      the distribution of confounding variables. Cox regression was conducted to 
      estimate hazard ratios (HRs) and 95% confidence intervals (CIs). RESULTS: 
      Overall, 31,378 patients met the eligibility criteria at an annual health 
      checkup. 9.6% received NG (n = 3013). Patients who attended >/= 1 NG after 
      diagnosis had significantly reduced risk of cardiovascular composite (adjusted HR 
      0.75, 95% CI 0.58-0.97) and cerebrovascular disease (adjusted HR 0.65, 95% CI 
      0.47-0.90) during approximately 3.3 years of follow-up. In contrast, no 
      difference was observed for CAD. CONCLUSIONS: Receiving NG in early-stage 
      diabetes may reduce the incidence of cardiovascular events, especially 
      cerebrovascular events.
CI  - (c) 2023. Springer-Verlag Italia S.r.l., part of Springer Nature.
FAU - Nakahata, Misaki
AU  - Nakahata M
AUID- ORCID: 0000-0002-0100-2863
AD  - Department of Pharmacoepidemiology, Graduate School of Medicine, Kyoto 
      University, Yoshidakonoe-Cho, Sakyo-Ku, Kyoto, 606-8501, Japan.
FAU - Tanaka-Mizuno, Sachiko
AU  - Tanaka-Mizuno S
AUID- ORCID: 0000-0003-0671-5376
AD  - Department of Pharmacoepidemiology, Graduate School of Medicine, Kyoto 
      University, Yoshidakonoe-Cho, Sakyo-Ku, Kyoto, 606-8501, Japan. 
      tanaka.sachiko.4m@kyoto-u.ac.jp.
AD  - Department of Digital Health and Epidemiology, Graduate School of Medicine, Kyoto 
      University, Yoshidakonoe-Cho, Sakyo-Ku, Kyoto, 606-8501, Japan. 
      tanaka.sachiko.4m@kyoto-u.ac.jp.
FAU - Yamaguchi, Fumitaka
AU  - Yamaguchi F
AUID- ORCID: 0009-0007-3449-7376
AD  - Department of Pharmacoepidemiology, Graduate School of Medicine, Kyoto 
      University, Yoshidakonoe-Cho, Sakyo-Ku, Kyoto, 606-8501, Japan.
FAU - Takeuchi, Masato
AU  - Takeuchi M
AUID- ORCID: 0000-0002-2990-2687
AD  - Department of Pharmacoepidemiology, Graduate School of Medicine, Kyoto 
      University, Yoshidakonoe-Cho, Sakyo-Ku, Kyoto, 606-8501, Japan.
FAU - Kawakami, Koji
AU  - Kawakami K
AUID- ORCID: 0000-0002-7477-4071
AD  - Department of Pharmacoepidemiology, Graduate School of Medicine, Kyoto 
      University, Yoshidakonoe-Cho, Sakyo-Ku, Kyoto, 606-8501, Japan.
LA  - eng
PT  - Journal Article
DEP - 20230708
PL  - Germany
TA  - Acta Diabetol
JT  - Acta diabetologica
JID - 9200299
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - Retrospective Studies
MH  - *Coronary Artery Disease/complications
MH  - *Cerebrovascular Disorders/epidemiology/etiology/prevention & control
MH  - Incidence
MH  - *Cardiovascular Diseases/epidemiology/etiology/prevention & control
OTO - NOTNLM
OT  - Cohort study
OT  - Diabetes complications
OT  - Dietary intervention
OT  - Macrovascular disease
OT  - Observational study
OT  - Real-world evidence
EDAT- 2023/07/08 19:41
MHDA- 2023/09/27 06:43
CRDT- 2023/07/08 11:03
PHST- 2023/03/19 00:00 [received]
PHST- 2023/06/25 00:00 [accepted]
PHST- 2023/09/27 06:43 [medline]
PHST- 2023/07/08 19:41 [pubmed]
PHST- 2023/07/08 11:03 [entrez]
AID - 10.1007/s00592-023-02147-3 [pii]
AID - 10.1007/s00592-023-02147-3 [doi]
PST - ppublish
SO  - Acta Diabetol. 2023 Nov;60(11):1541-1549. doi: 10.1007/s00592-023-02147-3. Epub 
      2023 Jul 8.