PMID- 37421845 OWN - NLM STAT- MEDLINE DCOM- 20230808 LR - 20230808 IS - 1873-2828 (Electronic) IS - 1350-4177 (Print) IS - 1350-4177 (Linking) VI - 98 DP - 2023 Aug TI - Natural deep eutectic solvents for Ultrasonic-Assisted extraction of nutritious date Sugar: Molecular Screening, Experimental, and prediction. PG - 106514 LID - S1350-4177(23)00226-2 [pii] LID - 10.1016/j.ultsonch.2023.106514 [doi] LID - 106514 AB - The aim of this study is to develop an environmentally friendly and effective method for the extraction of nutritious date sugar using natural deep eutectic solvents (NADES) and ultrasound-assisted extraction (USAE). The careful design of a suitable NADES-USAE system was systematically supported by COSMO-RS screening, response surface method (RSM) and artificial neural network (ANN). Initially, 26 natural hydrogen bond donors (HBDs) were carefully screened for sugar affinity using COSMO-RS. The best performing HBDs were then used for the synthesis of 5 NADES using choline chloride (ChCl) as HBA. Among the synthesized NADES, the mixture of ChCl, citric acid (CA) and water (1:1:1 with 20 wt% water) resulted in the highest sugar yield of 78.30 +/- 3.91 g/100 g, which is superior to conventional solvents such as water (29.92 +/- 1.50 g/100 g). Further enhancements using RSM and ANN led to an even higher sugar recovery of 87.81 +/- 2.61 g/100 g, at conditions of 30 degrees C, 45 min, and a solvent to DFP ratio of 40 mL/g. The method NADES-USAE was then compared with conventional hot water extraction (CHWE) (61.36 +/- 3.06) and showed 43.1% higher sugar yield. The developed process not only improves the recovery of the nutritious date sugar but also preserves the heat-sensitive bioactive compounds in dates, making it an attractive alternative to CHWE for industrial utilization. Overall, this study shows a promising approach for the extraction of nutritive sugars from dates using environmentally friendly solvents and advanced technology. It also highlights the potential of this approach for valorizing underutilized fruits and preserving their bioactive compounds. CI - Copyright (c) 2023. Published by Elsevier B.V. FAU - AlYammahi, Jawaher AU - AlYammahi J AD - Department of Chemical Engineering, Khalifa University of Science and Technology, PO Box 127788, Abu Dhabi, United Arab Emirates (UAE); Center for Membranes and Advanced Water Technology (CMAT), Khalifa University of Science and Technology, PO Box 127788, Abu Dhabi, UAE. FAU - Darwish, Ahmad S AU - Darwish AS AD - Department of Chemical Engineering, Khalifa University of Science and Technology, PO Box 127788, Abu Dhabi, United Arab Emirates (UAE); Center for Membranes and Advanced Water Technology (CMAT), Khalifa University of Science and Technology, PO Box 127788, Abu Dhabi, UAE. FAU - Almustafa, Ghaiath AU - Almustafa G AD - Department of Chemical Engineering, Khalifa University of Science and Technology, PO Box 127788, Abu Dhabi, United Arab Emirates (UAE). FAU - Lemaoui, Tarek AU - Lemaoui T AD - Department of Chemical Engineering, Khalifa University of Science and Technology, PO Box 127788, Abu Dhabi, United Arab Emirates (UAE); Research & Innovation Center for Graphene and 2D Materials (RIC-2D), Khalifa University, Abu Dhabi, P.O. Box 127788, United Arab Emirates. FAU - AlNashef, Inas M AU - AlNashef IM AD - Department of Chemical Engineering, Khalifa University of Science and Technology, PO Box 127788, Abu Dhabi, United Arab Emirates (UAE); Center for Membranes and Advanced Water Technology (CMAT), Khalifa University of Science and Technology, PO Box 127788, Abu Dhabi, UAE; Research & Innovation Center for Graphene and 2D Materials (RIC-2D), Khalifa University, Abu Dhabi, P.O. Box 127788, United Arab Emirates; Research and Innovation Center on CO(2) and H(2) (RICH), Khalifa University, Abu Dhabi, UAE. FAU - Hasan, Shadi W AU - Hasan SW AD - Department of Chemical Engineering, Khalifa University of Science and Technology, PO Box 127788, Abu Dhabi, United Arab Emirates (UAE); Center for Membranes and Advanced Water Technology (CMAT), Khalifa University of Science and Technology, PO Box 127788, Abu Dhabi, UAE. FAU - Taher, Hanifa AU - Taher H AD - Department of Chemical Engineering, Khalifa University of Science and Technology, PO Box 127788, Abu Dhabi, United Arab Emirates (UAE); Research and Innovation Center on CO(2) and H(2) (RICH), Khalifa University, Abu Dhabi, UAE. FAU - Banat, Fawzi AU - Banat F AD - Department of Chemical Engineering, Khalifa University of Science and Technology, PO Box 127788, Abu Dhabi, United Arab Emirates (UAE); Center for Membranes and Advanced Water Technology (CMAT), Khalifa University of Science and Technology, PO Box 127788, Abu Dhabi, UAE. Electronic address: fawzi.banat@ku.ac.ae. LA - eng PT - Journal Article DEP - 20230704 PL - Netherlands TA - Ultrason Sonochem JT - Ultrasonics sonochemistry JID - 9433356 RN - 0 (Deep Eutectic Solvents) RN - 0 (Sugars) RN - 0 (Plant Extracts) RN - 0 (Solvents) RN - 059QF0KO0R (Water) RN - N91BDP6H0X (Choline) SB - IM MH - *Deep Eutectic Solvents MH - *Sugars MH - Ultrasonics MH - Plant Extracts/chemistry MH - Solvents/chemistry MH - Water/chemistry MH - Choline/chemistry PMC - PMC10359946 OTO - NOTNLM OT - Artificial neural network OT - Date fruit OT - Green solvents OT - Response surface method OT - Ultrasonic-assisted extraction COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/07/09 01:07 MHDA- 2023/08/08 06:42 PMCR- 2023/07/04 CRDT- 2023/07/08 18:06 PHST- 2023/04/14 00:00 [received] PHST- 2023/06/29 00:00 [revised] PHST- 2023/07/03 00:00 [accepted] PHST- 2023/08/08 06:42 [medline] PHST- 2023/07/09 01:07 [pubmed] PHST- 2023/07/08 18:06 [entrez] PHST- 2023/07/04 00:00 [pmc-release] AID - S1350-4177(23)00226-2 [pii] AID - 106514 [pii] AID - 10.1016/j.ultsonch.2023.106514 [doi] PST - ppublish SO - Ultrason Sonochem. 2023 Aug;98:106514. doi: 10.1016/j.ultsonch.2023.106514. Epub 2023 Jul 4.