PMID- 37422165
OWN - NLM
STAT- MEDLINE
DCOM- 20230807
LR  - 20230807
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 202
DP  - 2023 Aug
TI  - Association of physical activity with total and cause-specific mortality in 
      patients with diabetes: A nationwide population-based cohort study.
PG  - 110819
LID - S0168-8227(23)00582-X [pii]
LID - 10.1016/j.diabres.2023.110819 [doi]
AB  - AIMS: Physical inactivity is a modifiable risk factor for cardiovascular disease 
      (CVD) in patients with type 2 diabetes mellitus (T2DM); however, little is known 
      about its association with mortality due to other causes. Herein, we investigated 
      the association between physical activity (PA) and cause-specific mortality in 
      patients with T2DM. METHODS: We analyzed data from the Korean National Health 
      Insurance Service and claims database of adults with T2DM aged >20 years at 
      baseline (n = 2,651,214). Each participant's PA volume was measured as the 
      metabolic equivalent of tasks (METs)-min per week, and hazard ratios of all-cause 
      and cause-specific mortality relative to PA levels were estimated. RESULTS: 
      During the 7.8 years of follow-up, all-cause, CVD, respiratory, cancer, and other 
      causes of mortality were lowest in patients engaged in vigorous PA. MET-min/week 
      was inversely associated with mortality after adjusting for covariates. The 
      reduction in total and cause-specific mortality was greater in patients aged 
      >/=65 years than in those aged <65 years. CONCLUSIONS: Increasing PA may facilitate 
      a reduction in mortality from various causes, especially among older patients 
      with T2DM. Clinicians should encourage such patients to increase their daily PA 
      levels to reduce their risk of mortality.
CI  - Copyright (c) 2023. Published by Elsevier B.V.
FAU - Jung, Inha
AU  - Jung I
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea 
      University Ansan Hospital, Ansan, Republic of Korea.
FAU - Han, Kyung-Do
AU  - Han KD
AD  - Department of Statistics and Actuarial Science, Soongsil University, Seoul, 
      Republic of Korea.
FAU - Moon, Sun Joon
AU  - Moon SJ
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, 
      Republic of Korea.
FAU - Kwon, Hyemi
AU  - Kwon H
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, 
      Republic of Korea.
FAU - Park, Se Eun
AU  - Park SE
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, 
      Republic of Korea.
FAU - Rhee, Eun-Jung
AU  - Rhee EJ
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, 
      Republic of Korea. Electronic address: drlwy@hanmail.net.
FAU - Lee, Won-Young
AU  - Lee WY
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, 
      Republic of Korea. Electronic address: hongsiri@hanmail.net.
LA  - eng
PT  - Journal Article
DEP - 20230707
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
SB  - IM
MH  - Adult
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Cohort Studies
MH  - Cause of Death
MH  - Exercise
MH  - Risk Factors
MH  - *Cardiovascular Diseases/etiology
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - Exercise benefit
OT  - Mortality
OT  - Physical activity
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/07/09 01:07
MHDA- 2023/08/07 06:42
CRDT- 2023/07/08 19:27
PHST- 2023/04/20 00:00 [received]
PHST- 2023/07/03 00:00 [revised]
PHST- 2023/07/06 00:00 [accepted]
PHST- 2023/08/07 06:42 [medline]
PHST- 2023/07/09 01:07 [pubmed]
PHST- 2023/07/08 19:27 [entrez]
AID - S0168-8227(23)00582-X [pii]
AID - 10.1016/j.diabres.2023.110819 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2023 Aug;202:110819. doi: 10.1016/j.diabres.2023.110819. 
      Epub 2023 Jul 7.