PMID- 37423180
OWN - NLM
STAT- MEDLINE
DCOM- 20230816
LR  - 20230816
IS  - 1095-7103 (Electronic)
IS  - 0021-9797 (Linking)
VI  - 650
IP  - Pt A
DP  - 2023 Nov 15
TI  - Three-pronged attacks by hybrid nanoassemblies involving a natural product, 
      carbon dots, and Cu(2+) for synergistic HCC therapy.
PG  - 526-540
LID - S0021-9797(23)01101-3 [pii]
LID - 10.1016/j.jcis.2023.06.074 [doi]
AB  - Tumor microenvironment (TME) stimuli-responsive nanoassemblies are emerging as 
      promising drug delivery systems (DDSs), which acquire controlled release by 
      structural transformation under exogenous stimulation. However, the design of 
      smart stimuli-responsive nanoplatforms integrated with nanomaterials to achieve 
      complete tumor ablation remains challenging. Therefore, it is of utmost 
      importance to develop TME-based stimuli-responsive DDSs to enhance drug-targeted 
      delivery and release at tumor sites. Herein, we proposed an appealing strategy to 
      construct fluorescence-mediated TME stimulus-responsive nanoplatforms for 
      synergistic cancer therapy by assembling photosensitizers (PSs) carbon dots 
      (CDs), chemotherapeutic agent ursolic acid (UA), and copper ions (Cu(2+)). First, 
      UA nanoparticles (UA NPs) were prepared by self-assembly of UA, then UA NPs were 
      assembled with CDs via hydrogen bonding force to obtain UC NPs. After combining 
      with Cu(2+), the resulting particles (named UCCu(2+) NPs) exhibited quenched 
      fluorescence and photosensitization due to the aggregation of UC NPs. Upon 
      entering the tumor tissue, the photodynamic therapy (PDT) and the fluorescence 
      function of UCCu(2+) were recovered in response to TME stimulation. The 
      introduction of Cu(2+) triggered the charge reversal of UCCu(2+) NPs, thereby 
      promoting lysosomal escape. Furthermore, Cu(2+) resulted in additional 
      chemodynamic therapy (CDT) capacity by reacting with hydrogen peroxide (H(2)O(2)) 
      as well as by consuming glutathione (GSH) in cancer cells through a redox 
      reaction, hence magnifying intracellular oxidative stress and enhancing the 
      therapeutic efficacy due to reactive oxygen species (ROS) therapy. In summary, 
      UCCu(2+) NPs provided an unprecedented novel approach for improving the 
      therapeutic efficacy through the three-pronged (chemotherapy, phototherapy, and 
      heat-reinforced CDT) attacks to achieve synergistic therapy.
CI  - Copyright (c) 2023. Published by Elsevier Inc.
FAU - Lai, Chun-Mei
AU  - Lai CM
AD  - Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and 
      Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, 
      China.
FAU - Xu, Jia
AU  - Xu J
AD  - Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and 
      Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, 
      China.
FAU - Zhang, Bing-Chen
AU  - Zhang BC
AD  - Dongguan Institute of Clinical Cancer Research, Dongguan Key Laboratory of 
      Precision Diagnosis and Treatment for Tumors, Affiliated Dongguan Hospital, 
      Southern Medical University, Dongguan, China.
FAU - Li, Dong-Miao
AU  - Li DM
AD  - Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and 
      Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, 
      China.
FAU - Shen, Jiang-Wen
AU  - Shen JW
AD  - Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and 
      Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, 
      China.
FAU - Yu, Shi-Jing
AU  - Yu SJ
AD  - Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and 
      Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, 
      China.
FAU - Shao, Jing-Wei
AU  - Shao JW
AD  - Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and 
      Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, 
      China. Electronic address: shaojingwei@fzu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20230614
PL  - United States
TA  - J Colloid Interface Sci
JT  - Journal of colloid and interface science
JID - 0043125
RN  - 789U1901C5 (Copper)
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - 0 (Biological Products)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Humans
MH  - Copper/chemistry
MH  - *Carcinoma, Hepatocellular/drug therapy
MH  - Hydrogen Peroxide
MH  - *Biological Products
MH  - *Liver Neoplasms/drug therapy
MH  - *Nanoparticles/chemistry
MH  - Cell Line, Tumor
MH  - *Neoplasms/drug therapy
MH  - Glutathione
MH  - Tumor Microenvironment
OTO - NOTNLM
OT  - Stimuli-responsive
OT  - Synergistic therapy
OT  - Three-pronged attack
OT  - Tumor microenvironment
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/07/10 00:41
MHDA- 2023/08/16 06:43
CRDT- 2023/07/09 18:09
PHST- 2023/03/18 00:00 [received]
PHST- 2023/06/09 00:00 [revised]
PHST- 2023/06/12 00:00 [accepted]
PHST- 2023/08/16 06:43 [medline]
PHST- 2023/07/10 00:41 [pubmed]
PHST- 2023/07/09 18:09 [entrez]
AID - S0021-9797(23)01101-3 [pii]
AID - 10.1016/j.jcis.2023.06.074 [doi]
PST - ppublish
SO  - J Colloid Interface Sci. 2023 Nov 15;650(Pt A):526-540. doi: 
      10.1016/j.jcis.2023.06.074. Epub 2023 Jun 14.