PMID- 37423962
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230727
IS  - 2193-8210 (Print)
IS  - 2190-9172 (Electronic)
VI  - 13
IP  - 8
DP  - 2023 Aug
TI  - Markers of Venous Thromboembolism Risk in Patients with Alopecia Areata: Is There 
      Anything to Worry about?
PG  - 1847-1855
LID - 10.1007/s13555-023-00971-7 [doi]
AB  - BACKGROUND: Numerous studies have indicated that alopecia areata is associated 
      with a chronic systemic inflammation, which is considered as a risk factor for 
      venous thromboembolism. The aim of the study was to evaluate the following 
      markers of venous thromboembolism risk: soluble fibrin monomer complex (SFMC), 
      thrombin-antithrombin complex (TATC), and prothrombin fragment 1 + 2 (F1 + 2) in 
      patients with alopecia areata and compare them with healthy controls. METHODS: In 
      total, 51 patients with alopecia areata [35 women and 16 men; mean age: 38 
      (19-54) years] and 26 controls [18 women and 8 men; mean age: 37 (29-51) years] 
      were enrolled in the study. The serum concentrations of thromboembolism markers 
      were measured using an enzyme-linked immunosorbent assay (ELISA) kit. RESULTS: An 
      increased level of SFMC was detected in patients with alopecia areata compared 
      with the controls [25.66 (20-34.86) versus 21.46 (15.38-29.48) microg/ml; p < 0.05)]. 
      In addition, a higher level of F1 + 2 was observed in patients with alopecia 
      areata in comparison with the control group [70150 (43720-86070) versus 38620 
      (31550-58840) pg/ml; p < 0.001]. No significant correlation was detected among 
      SFMC or F1 + 2 and the Severity of Alopecia Tool (SALT) score, disease duration, 
      or the number of the hair loss episodes. CONCLUSION: Alopecia areata may be 
      associated with an increased risk of venous thromboembolism. Regular screening 
      and preventive management of venous thromboembolism may be beneficial in patients 
      with alopecia areata, especially before and during systemic Janus kinase (JAK) 
      inhibitors or glucocorticoid therapy.
CI  - (c) 2023. The Author(s).
FAU - Waskiel-Burnat, Anna
AU  - Waskiel-Burnat A
AUID- ORCID: 0000-0003-4984-3589
AD  - Department of Dermatology, Medical University of Warsaw, Warsaw, Poland. 
      anna.waskiel@wum.edu.pl.
FAU - Rakowska, Adriana
AU  - Rakowska A
AD  - Department of Dermatology, Medical University of Warsaw, Warsaw, Poland.
FAU - Zaremba, Michal
AU  - Zaremba M
AD  - Department of Dermatology, Medical University of Warsaw, Warsaw, Poland.
FAU - Maciejewska, Magdalena
AU  - Maciejewska M
AD  - Department of Dermatology, Medical University of Warsaw, Warsaw, Poland.
FAU - Blicharz, Leszek
AU  - Blicharz L
AD  - Department of Dermatology, Medical University of Warsaw, Warsaw, Poland.
FAU - Starace, Michela
AU  - Starace M
AD  - Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico 
      S. Orsola Malpighi, Bologna, Italy.
AD  - Department of Medical and Surgical Sciences, Alma Mater Studiorum University of 
      Bologna, Bologna, Italy.
FAU - Iorizzo, Matilde
AU  - Iorizzo M
AD  - Private Dermatology Practice, Bellinzona/Lugano, Switzerland.
FAU - Piraccini, Bianca Maria
AU  - Piraccini BM
AD  - Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico 
      S. Orsola Malpighi, Bologna, Italy.
AD  - Department of Medical and Surgical Sciences, Alma Mater Studiorum University of 
      Bologna, Bologna, Italy.
FAU - Olszewska, Malgorzata
AU  - Olszewska M
AD  - Department of Dermatology, Medical University of Warsaw, Warsaw, Poland.
FAU - Rudnicka, Lidia
AU  - Rudnicka L
AD  - Department of Dermatology, Medical University of Warsaw, Warsaw, Poland.
LA  - eng
PT  - Journal Article
DEP - 20230709
PL  - Switzerland
TA  - Dermatol Ther (Heidelb)
JT  - Dermatology and therapy
JID - 101590450
PMC - PMC10366048
OTO - NOTNLM
OT  - Autoimmune disease
OT  - Blood clot
OT  - Embolism
OT  - Hair loss
OT  - Thrombosis
OT  - Thrombotic risk
COIS- Anna Waskiel-Burnat, Adriana Rakowska, Michal Zaremba, Magdalena Maciejewska, 
      Leszek Blicharz, Michela Starace, Matilde Iorizzo, Bianca Maria Piraccini, 
      Malgorzata Olszewska and Lidia Rudnicka have nothing to disclose.
EDAT- 2023/07/10 00:42
MHDA- 2023/07/10 00:43
PMCR- 2023/07/09
CRDT- 2023/07/09 23:07
PHST- 2023/04/11 00:00 [received]
PHST- 2023/06/19 00:00 [accepted]
PHST- 2023/07/10 00:43 [medline]
PHST- 2023/07/10 00:42 [pubmed]
PHST- 2023/07/09 23:07 [entrez]
PHST- 2023/07/09 00:00 [pmc-release]
AID - 10.1007/s13555-023-00971-7 [pii]
AID - 971 [pii]
AID - 10.1007/s13555-023-00971-7 [doi]
PST - ppublish
SO  - Dermatol Ther (Heidelb). 2023 Aug;13(8):1847-1855. doi: 
      10.1007/s13555-023-00971-7. Epub 2023 Jul 9.