PMID- 37425840
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240313
DP  - 2023 Jun 29
TI  - Targeting hepatitis B vaccine escape using immunogenetics in Bangladeshi infants.
LID - 2023.06.26.23291885 [pii]
LID - 10.1101/2023.06.26.23291885 [doi]
AB  - Hepatitis B virus (HBV) vaccine escape mutants (VEM) are increasingly described, 
      threatening progress in control of this virus worldwide. Here we studied the 
      relationship between host genetic variation, vaccine immunogenicity and viral 
      sequences implicating VEM emergence. In a cohort of 1,096 Bangladeshi children, 
      we identified human leukocyte antigen (HLA) variants associated with response 
      vaccine antigens. Using an HLA imputation panel with 9,448 south Asian 
      individuals DPB1*04:01 was associated with higher HBV antibody responses 
      (p=4.5x10(-30)). The underlying mechanism is a result of higher affinity binding 
      of HBV surface antigen epitopes to DPB1*04:01 dimers. This is likely a result of 
      evolutionary pressure at the HBV surface antigen 'a-determinant' segment 
      incurring VEM specific to HBV. Prioritizing pre-S isoform HBV vaccines may tackle 
      the rise of HBV vaccine evasion.
FAU - Butler-Laporte, Guillaume
AU  - Butler-Laporte G
AD  - Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
AD  - Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, 
      Quebec, Canada.
AD  - Division of Infectious Diseases, McGill University Health Centre, Montreal, 
      Quebec, Canada.
FAU - Auckland, Kathryn
AU  - Auckland K
AD  - Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
FAU - Noor, Zannatun
AU  - Noor Z
AD  - International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, 
      Bangladesh.
FAU - Kabir, Mamun
AU  - Kabir M
AD  - International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, 
      Bangladesh.
FAU - Alam, Masud
AU  - Alam M
AD  - International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, 
      Bangladesh.
FAU - Carstensen, Tommy
AU  - Carstensen T
AD  - Wellcome Trust Sanger Institute, University of Cambridge, Hinxton, United 
      Kingdom.
AD  - Queen Mary University of London, London, United Kingdom.
FAU - Wojcik, Genevieve L
AU  - Wojcik GL
AD  - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 
      Baltimore, Maryland, USA.
FAU - Chong, Amanda Y
AU  - Chong AY
AD  - Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
FAU - Pomilla, Cristina
AU  - Pomilla C
AD  - Wellcome Trust Sanger Institute, University of Cambridge, Hinxton, United 
      Kingdom.
FAU - Noble, Janelle A
AU  - Noble JA
AD  - Children's Hospital Oakland Research Institute, Oakland, California, USA.
AD  - Department of Pediatrics, University of California, San Francisco, California, 
      USA.
FAU - McDevitt, Shana L
AU  - McDevitt SL
AD  - Media Labs, Inc. Alameda, CA, USA.
FAU - Smits, Gaby
AU  - Smits G
AD  - National Institute for Public Health and the Environment, Bilthoven, The 
      Netherlands.
FAU - Wareing, Susan
AU  - Wareing S
AD  - Microbiology Department, John Radcliffe Hospital, Oxford University NHS 
      Foundation Trust, Oxford, UK.
FAU - van der Klis, Fiona Rm
AU  - van der Klis FR
AD  - National Institute for Public Health and the Environment, Bilthoven, The 
      Netherlands.
FAU - Jeffery, Katie
AU  - Jeffery K
AD  - Microbiology Department, John Radcliffe Hospital, Oxford University NHS 
      Foundation Trust, Oxford, UK.
FAU - Kirkpatrick, Beth D
AU  - Kirkpatrick BD
AD  - Department of Microbiology and Molecular Genetics, Vaccine Testing Center, 
      University of Vermont College of Medicine, Vermont, USA.
FAU - Sirima, Sodiomon
AU  - Sirima S
AD  - Groupe de Recherche Action en Sante (GRAS) 06 BP 10248 Ouagadougou, Burkina Faso.
FAU - Madhi, Shabir
AU  - Madhi S
AD  - South African Medical Research Council Vaccines and Infectious Diseases Analytics 
      Research Unit, University of the Witwatersrand, Johannesburg, South Africa.
FAU - Elliott, Alison
AU  - Elliott A
AD  - Department of Clinical Research, London School of Hygiene & Tropical Medicine, 
      London, UK.
AD  - Medical Research Council/Uganda Virus Research Institute and London School of 
      Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda.
FAU - Richards, J Brent
AU  - Richards JB
AD  - Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, 
      Quebec, Canada.
AD  - Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
AD  - 5 Prime Sciences Inc, Montreal, Quebec, Canada.
AD  - Department of Epidemiology, Biostatistics and Occupational Health, McGill 
      University, Montreal, Quebec, Canada.
AD  - Department of Twin Research, King's College London, London, United Kingdom.
FAU - Hill, Adrian Vs
AU  - Hill AV
AD  - The Jenner Institute, University of Oxford, Oxford, United Kingdom.
FAU - Duggal, Priya
AU  - Duggal P
AD  - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 
      Baltimore, Maryland, USA.
CN  - PROVIDE authors, Cryptosporidiosis Birth Cohort authors
FAU - Sandhu, Manjinder S
AU  - Sandhu MS
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Imperial 
      College London, United Kingdom.
FAU - Haque, Rashidul
AU  - Haque R
AD  - International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, 
      Bangladesh.
FAU - Petri, William A Jr
AU  - Petri WA Jr
AD  - Department of Medicine, Infectious Diseases and International Health, University 
      of Virginia School of Medicine, Charlottesville, Virginia, USA.
FAU - Mentzer, Alexander J
AU  - Mentzer AJ
AD  - Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
LA  - eng
GR  - MR/K019708/1/MRC_/Medical Research Council/United Kingdom
GR  - R01 AI043596/AI/NIAID NIH HHS/United States
GR  - MC_UU_00027/5/MRC_/Medical Research Council/United Kingdom
GR  - WT_/Wellcome Trust/United Kingdom
GR  - R37 AI026649/AI/NIAID NIH HHS/United States
PT  - Preprint
DEP - 20230629
PL  - United States
TA  - medRxiv
JT  - medRxiv : the preprint server for health sciences
JID - 101767986
PMC - PMC10327284
OTO - NOTNLM
OT  - Genome-wide association studies
OT  - escape variants
OT  - hepatitis B virus
OT  - human leukocyte antigen
OT  - major histocompatibility complex
OT  - vaccination
COIS- Competing interests: JBR's institution has received investigator-initiated grant 
      funding from Eli Lilly, GlaxoSmithKline and Biogen for projects unrelated to this 
      research. He is the CEO of 5 Prime Sciences Inc (www.5primesciences.com).
EDAT- 2023/07/10 06:42
MHDA- 2023/07/10 06:43
PMCR- 2023/07/07
CRDT- 2023/07/10 05:02
PHST- 2023/07/10 06:42 [pubmed]
PHST- 2023/07/10 06:43 [medline]
PHST- 2023/07/10 05:02 [entrez]
PHST- 2023/07/07 00:00 [pmc-release]
AID - 2023.06.26.23291885 [pii]
AID - 10.1101/2023.06.26.23291885 [doi]
PST - epublish
SO  - medRxiv [Preprint]. 2023 Jun 29:2023.06.26.23291885. doi: 
      10.1101/2023.06.26.23291885.