PMID- 37426269
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230718
IS  - 2470-1343 (Electronic)
IS  - 2470-1343 (Linking)
VI  - 8
IP  - 26
DP  - 2023 Jul 4
TI  - Determination of the Dissipation Dynamics and Terminal Residue of Bupirimate and 
      Its Metabolites in Cucumber by QuEChERS-Based UPLC-MS/MS.
PG  - 23975-23981
LID - 10.1021/acsomega.3c02644 [doi]
AB  - Bupirimate is widely used as a highly active systemic fungicide. However, the 
      frequent and heavy use of bupirimate has led to pesticide residues in crops that 
      threaten human health and food safety. At present, there is limited research on 
      the detection of ethirimol, which is the metabolite of bupirimate. This study 
      established an ultrahigh-performance liquid chromatography-tandem mass 
      spectrometry (UPLC-MS/MS) method to simultaneously detect bupirimate and 
      ethirimol residues based on QuEChERS pretreatment. The average recoveries of 
      bupirimate and ethirimol in cucumber were between 95.2 and 98.7%, respectively, 
      with relative standard deviations (RSDs) of 0.92-5.54% at fortified levels of 
      0.01, 0.1, and 5 mg L(-1). The established method was used to determine the 
      residues in field trials in 12 regions of China, and the final residues of 
      bupirimate were all less than the maximum residue limit (MRL). Since the risk 
      quotient (RQ) of bupirimate and ethirimol in cucumber was less than 1.3%, the 
      dietary risk assessment indicated that bupirimate and ethirimol had a low 
      long-term dietary risk to the general population in China. This study provides 
      effective guidance on the proper use of bupirimate in cucumber fields and a 
      reference for establishing the MRL of bupirimate in China.
CI  - (c) 2023 The Authors. Published by American Chemical Society.
FAU - Chen, Yue
AU  - Chen Y
AD  - Shandong Academy of Pesticide Sciences, Jinan, Shandong 250033, China.
AD  - College of Plant Protection, Shandong Agricultural University, Tai'an, Shandong 
      271018, China.
FAU - Gao, Deliang
AU  - Gao D
AD  - Shandong Academy of Pesticide Sciences, Jinan, Shandong 250033, China.
FAU - Wu, Yueming
AU  - Wu Y
AD  - College of Plant Protection, Shandong Agricultural University, Tai'an, Shandong 
      271018, China.
FAU - Wang, Ling
AU  - Wang L
AD  - Research Center of Pesticide Environmental Toxicology, Shandong Agricultural 
      University, Tai'an, Shandong 271018, China.
FAU - Fan, Weidi
AU  - Fan W
AD  - Research Center of Pesticide Environmental Toxicology, Shandong Agricultural 
      University, Tai'an, Shandong 271018, China.
FAU - Gao, Yun
AU  - Gao Y
AD  - Research Center of Pesticide Environmental Toxicology, Shandong Agricultural 
      University, Tai'an, Shandong 271018, China.
FAU - Wang, Wenli
AU  - Wang W
AD  - Research Center of Pesticide Environmental Toxicology, Shandong Agricultural 
      University, Tai'an, Shandong 271018, China.
FAU - Su, Li
AU  - Su L
AD  - Research Center of Pesticide Environmental Toxicology, Shandong Agricultural 
      University, Tai'an, Shandong 271018, China.
FAU - Li, Beixing
AU  - Li B
AD  - College of Plant Protection, Shandong Agricultural University, Tai'an, Shandong 
      271018, China.
AD  - Research Center of Pesticide Environmental Toxicology, Shandong Agricultural 
      University, Tai'an, Shandong 271018, China.
FAU - Mu, Wei
AU  - Mu W
AUID- ORCID: 0000-0002-9836-478X
AD  - College of Plant Protection, Shandong Agricultural University, Tai'an, Shandong 
      271018, China.
AD  - Research Center of Pesticide Environmental Toxicology, Shandong Agricultural 
      University, Tai'an, Shandong 271018, China.
FAU - Yu, Weili
AU  - Yu W
AUID- ORCID: 0009-0004-4968-5992
AD  - Shandong Academy of Pesticide Sciences, Jinan, Shandong 250033, China.
LA  - eng
PT  - Journal Article
DEP - 20230625
PL  - United States
TA  - ACS Omega
JT  - ACS omega
JID - 101691658
PMC - PMC10323959
COIS- The authors declare no competing financial interest.
EDAT- 2023/07/10 06:42
MHDA- 2023/07/10 06:43
PMCR- 2023/06/25
CRDT- 2023/07/10 05:07
PHST- 2023/04/18 00:00 [received]
PHST- 2023/06/01 00:00 [accepted]
PHST- 2023/07/10 06:43 [medline]
PHST- 2023/07/10 06:42 [pubmed]
PHST- 2023/07/10 05:07 [entrez]
PHST- 2023/06/25 00:00 [pmc-release]
AID - 10.1021/acsomega.3c02644 [doi]
PST - epublish
SO  - ACS Omega. 2023 Jun 25;8(26):23975-23981. doi: 10.1021/acsomega.3c02644. 
      eCollection 2023 Jul 4.