PMID- 37426516
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230718
IS  - 1178-7074 (Print)
IS  - 1178-7074 (Electronic)
IS  - 1178-7074 (Linking)
VI  - 16
DP  - 2023
TI  - Association of Triglyceride-Glucose Index with the Risk of Hyperhomocysteinemia 
      Among Chinese Male Bus Drivers: A Longitudinal Study.
PG  - 2857-2866
LID - 10.2147/IJGM.S416230 [doi]
AB  - BACKGROUND: Insulin resistance (IR) and hyperhomocysteinemia (HHcy) are 
      significant risk factors for cardiovascular disease (CVD). As an important marker 
      for IR, Triglyceride-Glucose (TyG) index maybe a significant predictor for HHcy 
      progression, reflecting cardiovascular risk. However, the relationship between 
      TyG index and HHcy has been unknown, especially for the high-risk occupation 
      group of male bus drivers. This longitudinal study was initially conducted to 
      explore the outcome of TyG index in predicting HHcy among male bus drivers. 
      METHODS: In total, 1018 Chinese male bus drivers with Hcy data and regular 
      follow-up from 2017 to 2021 were screened, and 523 non-HHcy subjects at baseline 
      were included in the longitudinal cohort. A restricted cubic spline (RCS) was 
      performed to investigate the possible non-linear relationship between TyG index 
      and the progression of HHcy. A multivariate logistic regression model was used to 
      explore the association between TyG index and developing HHcy via assessing the 
      value of odds ratio (OR) and 95% confidence interval (CI). RESULTS: After the 
      median follow up time of 2.12 years, approximately 27.7% of male bus drivers 
      (mean age: 48.1 years) was identified as new incidents HHcy. Multivariate 
      logistic regression found that the higher level of TyG was associated with an 
      increased risk of new onset HHcy (OR = 1.47; 95% CI: 1.11-1.94); and the 
      association seemed to be strong among male bus drivers with elevated low-density 
      lipoprotein cholesterol (LDL-C) (P for interaction < 0.05). CONCLUSION: As a 
      higher risk occupation group for HHcy, male bus drivers should cause much more 
      attentions from policy makers, employers, and health professionals in China. 
      Identifying male bus drivers with HHcy is of significance at an earlier stage in 
      the primary care setting. Being a significant predictive factor for HHcy, TyG 
      index could be used to monitor and prevent Chinese male bus drivers from HHcy, 
      especially for individuals with elevated LDL-C.
CI  - (c) 2023 Xiong et al.
FAU - Xiong, Juan
AU  - Xiong J
AUID- ORCID: 0000-0002-6702-6585
AD  - Medical School, Shenzhen University, Shenzhen, 518060, People's Republic of 
      China.
FAU - Wu, Yanxia
AU  - Wu Y
AD  - Department of Health Management, Shenzhen People's Hospital, Shenzhen City, 
      People's Republic of China.
FAU - Huang, Lingling
AU  - Huang L
AD  - Medical School, Shenzhen University, Shenzhen, 518060, People's Republic of 
      China.
FAU - Zheng, Xujuan
AU  - Zheng X
AD  - Medical School, Shenzhen University, Shenzhen, 518060, People's Republic of 
      China.
LA  - eng
PT  - Journal Article
DEP - 20230704
PL  - New Zealand
TA  - Int J Gen Med
JT  - International journal of general medicine
JID - 101515487
PMC - PMC10329442
OTO - NOTNLM
OT  - HHcy
OT  - IR
OT  - TyG
OT  - hyperhomocysteinemia
OT  - insulin resistance
OT  - longitudinal study
OT  - male bus drivers
OT  - triglyceride-glucose index
COIS- The authors declare no conflicts of interest.
EDAT- 2023/07/10 06:42
MHDA- 2023/07/10 06:43
PMCR- 2023/07/04
CRDT- 2023/07/10 05:10
PHST- 2023/04/07 00:00 [received]
PHST- 2023/06/27 00:00 [accepted]
PHST- 2023/07/10 06:43 [medline]
PHST- 2023/07/10 06:42 [pubmed]
PHST- 2023/07/10 05:10 [entrez]
PHST- 2023/07/04 00:00 [pmc-release]
AID - 416230 [pii]
AID - 10.2147/IJGM.S416230 [doi]
PST - epublish
SO  - Int J Gen Med. 2023 Jul 4;16:2857-2866. doi: 10.2147/IJGM.S416230. eCollection 
      2023.